The hinge-arm region of HBx-Smc5/6 ubiquitination complex. Determined by electron microscopy at 7.32 Å resolution. Released 29 Apr 2026.
Explore 9LWK in 3D Show helices and sheets RCSB PDB PDBe
9LWK contains 40 α-helices and 15 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 362-385 | 24 | |
| α-helix | 388-391 | 4 | |
| α-helix | 393-395 | 3 | |
| α-helix | 399-406 | 8 | |
| α-helix | 407-409 | 3 | |
| α-helix | 411-417 | 7 | |
| α-helix | 418-473 | 56 | |
| α-helix | 483-496 | 14 | |
| α-helix | 508-511 | 4 | |
| α-helix | 520-527 | 8 | |
| α-helix | 528-531 | 4 | |
| α-helix | 533 | 1 | |
| β-strand | 534-536 | 3 | 1 |
| α-helix | 539-552 | 14 | |
| α-helix | 554 | 1 | |
| α-helix | 558-561 | 4 | |
| β-strand | 562-564 | 3 | 1 |
| α-helix | 571-572 | 2 | |
| α-helix | 575-577 | 3 | |
| β-strand | 580 | 1 | 2 |
| α-helix | 588-590 | 3 | |
| α-helix | 596-604 | 9 | |
| β-strand | 611-614 | 4 | 3 |
| α-helix | 617-625 | 9 | |
| α-helix | 628-630 | 3 | |
| β-strand | 631 | 1 | 2 |
| β-strand | 635-638 | 4 | 3 |
| β-strand | 643-645 | 3 | 3 |
| β-strand | 649 | 1 | 3 |
| α-helix | 664-728 | 65 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 356-384 | 29 | |
| α-helix | 405-412 | 8 | |
| α-helix | 419-445 | 27 | |
| α-helix | 448-459 | 12 | |
| α-helix | 461-472 | 12 | |
| α-helix | 482-484 | 3 | |
| α-helix | 485-488 | 4 | |
| α-helix | 496-502 | 7 | |
| α-helix | 506-510 | 5 | |
| β-strand | 512-514 | 3 | 4 |
| α-helix | 517-526 | 10 | |
| α-helix | 527-531 | 5 | |
| β-strand | 537-539 | 3 | 4 |
| α-helix | 548-550 | 3 | |
| α-helix | 554-560 | 7 | |
| β-strand | 564-565 | 2 | 5 |
| α-helix | 574-584 | 11 | |
| β-strand | 590-591 | 2 | 5 |
| α-helix | 594-607 | 14 | |
| β-strand | 611-613 | 3 | 1 |
| β-strand | 617-623 | 7 | 1 |
| β-strand | 630-636 | 7 | 1 |
| α-helix | 637-639 | 3 | |
| α-helix | 649-688 | 40 | |
| α-helix | 702-719 | 18 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Structural maintenance of chromosomes protein 6 | A | protein | 1091 | Homo sapiens | Q96SB8 (AlphaFold model) |
| Structural maintenance of chromosomes protein 5 | I | protein | 1101 | Homo sapiens | Q8IY18 (AlphaFold model) |
>9LWK_1 Structural maintenance of chromosomes protein 6 (chains A) MAKRKEENFSSPKNAKRPRQEELEDFDKDGDEDECKGTTLTAAEVGIIESIHLKNFMCHS MLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVKDGQNSADIS ITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSVVSTRKEELIAILDHFNI QVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQG EERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIG EDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAY NEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAF QNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRF GPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHA DERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVAN SLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFL SRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKN ISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKY DAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKE KELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARE TYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNF DHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVY MDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFR PVTQEEDDDQR
>9LWK_2 Structural maintenance of chromosomes protein 5 (chains I) MATPSKKTSTPSPQPSKRALPRDPSSEVPSKRKNSAPQLPLLQSSGPFVEGSIVRISMEN FLTYDICEVSPGPHLNMIVGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVKRGCSR GMVEIELFRASGNLVITREIDVAKNQSFWFINKKSTTQKIVEEKVAALNIQVGNLCQFLP QDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMV QRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLK EGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALI VKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGE IIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQR VCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIA PKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERI ERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLK EIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKL MEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISE KNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQ TQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEI EQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHT ENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDE INQGMDPINERRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVLFVYNGPHMLEP NTWNLKAFQRRRRRITFTQPS
Structural and functional insights into HBx-Smc6 targeting for HBV inhibition. Cheng, T., Zhou, J., Huang, W. et al. Cell Res (2026) 36:629-632. DOI 10.1038/s41422-026-01251-7 · PubMed
Other PDB entries of the same protein (UniProt Q96SB8 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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