9LWL: HBx-Smc5/6 ubiquitination complex
HBx-Smc5/6 ubiquitination complex. Determined by electron microscopy at 7.25 Å resolution. Released 29 Apr 2026.
- Method
- Electron microscopy
- Resolution
- 7.25 Å
- Organisms
- Homo sapiens, Hepatitis B virus
- Chains
- 10
- Atoms
- 39,737
- Mol. weight
- 631.24 kDa
- Ligands
- ZN
- Released
- 29 Apr 2026
Explore 9LWL in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9LWL contains 190 α-helices and 194 β-strands across 10 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 36 helices, 27 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 45-52 | 8 | 1 |
| β-strand | 56 | 1 | 2 |
| β-strand | 59 | 1 | 2 |
| β-strand | 72-75 | 4 | 3 |
| α-helix | 84-92 | 9 | |
| α-helix | 97-99 | 3 | |
| β-strand | 100 | 1 | 4 |
| β-strand | 103 | 1 | 4 |
| α-helix | 111 | 1 | |
| β-strand | 116-125 | 10 | 1 |
| α-helix | 133-136 | 4 | |
| β-strand | 139-147 | 9 | 1 |
| β-strand | 152-157 | 6 | 1 |
| β-strand | 163-165 | 3 | 1 |
| α-helix | 168-177 | 10 | |
| α-helix | 191-194 | 4 | |
| α-helix | 195-199 | 5 | |
| α-helix | 203-214 | 12 | |
| α-helix | 216-376 | 161 | |
| α-helix | 378-383 | 6 | |
| α-helix | 388-391 | 4 | |
| α-helix | 393-395 | 3 | |
| α-helix | 399-406 | 8 | |
| α-helix | 407-409 | 3 | |
| α-helix | 411-417 | 7 | |
| α-helix | 418-473 | 56 | |
| α-helix | 483-496 | 14 | |
| α-helix | 508-511 | 4 | |
| α-helix | 520-527 | 8 | |
| α-helix | 528-531 | 4 | |
| α-helix | 533 | 1 | |
| β-strand | 534-536 | 3 | 5 |
| α-helix | 539-552 | 14 | |
| α-helix | 554 | 1 | |
| α-helix | 558-561 | 4 | |
| β-strand | 562-564 | 3 | 5 |
| α-helix | 571-572 | 2 | |
| α-helix | 575-577 | 3 | |
| β-strand | 580 | 1 | 6 |
| α-helix | 588-590 | 3 | |
| α-helix | 596-604 | 9 | |
| β-strand | 611-614 | 4 | 7 |
| α-helix | 617-625 | 9 | |
| α-helix | 628-630 | 3 | |
| β-strand | 631 | 1 | 6 |
| β-strand | 635-638 | 4 | 7 |
| β-strand | 643-645 | 3 | 7 |
| β-strand | 649 | 1 | 7 |
| α-helix | 664-726 | 63 | |
| α-helix | 742-850 | 109 | |
| α-helix | 864-885 | 22 | |
| α-helix | 892-951 | 60 | |
| β-strand | 955 | 1 | 8 |
| β-strand | 958-961 | 4 | 9 |
| β-strand | 966-969 | 4 | 9 |
| β-strand | 972 | 1 | 8 |
| α-helix | 991-1006 | 16 | |
| β-strand | 1011-1012 | 2 | 10 |
| β-strand | 1015 | 1 | 3 |
| α-helix | 1023-1039 | 17 | |
| β-strand | 1044-1045 | 2 | 10 |
| β-strand | 1046-1049 | 4 | 3 |
| β-strand | 1064-1065 | 2 | 3 |
Chain B: 11 helices, 100 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-10 | 7 | 11 |
| β-strand | 17-21 | 5 | 12 |
| β-strand | 30-34 | 5 | 12 |
| β-strand | 38-43 | 6 | 12 |
| β-strand | 50-56 | 7 | 12 |
| β-strand | 64-67 | 4 | 13 |
| β-strand | 76-80 | 5 | 13 |
| β-strand | 85-94 | 10 | 13 |
| β-strand | 97-107 | 11 | 13 |
| β-strand | 115 | 1 | 14 |
| β-strand | 123-124 | 2 | 14 |
| β-strand | 130-136 | 7 | 14 |
| β-strand | 139-144 | 6 | 14 |
| β-strand | 155-158 | 4 | 14 |
| β-strand | 164-169 | 6 | 15 |
| α-helix | 170 | 1 | |
| β-strand | 177-182 | 6 | 15 |
| β-strand | 189-196 | 8 | 15 |
| β-strand | 201-209 | 9 | 15 |
| β-strand | 218 | 1 | 16 |
| β-strand | 221 | 1 | 16 |
| β-strand | 229-232 | 4 | 16 |
| β-strand | 237-240 | 4 | 16 |
| β-strand | 247-248 | 2 | 16 |
| α-helix | 253-255 | 3 | |
| β-strand | 258-263 | 6 | 17 |
| β-strand | 270-275 | 6 | 17 |
| β-strand | 279-289 | 11 | 17 |
| β-strand | 295-307 | 13 | 17 |
| β-strand | 313-318 | 6 | 18 |
| β-strand | 321-325 | 5 | 18 |
| β-strand | 331-336 | 6 | 18 |
| α-helix | 342-344 | 3 | |
| β-strand | 347-353 | 7 | 18 |
| β-strand | 359-363 | 5 | 19 |
| β-strand | 376-379 | 4 | 19 |
| β-strand | 386-391 | 6 | 19 |
| β-strand | 394 | 1 | 20 |
| β-strand | 396-402 | 7 | 21 |
| β-strand | 407-413 | 7 | 22 |
| β-strand | 424-429 | 6 | 22 |
| β-strand | 433-439 | 7 | 22 |
| β-strand | 442-445 | 4 | 22 |
| β-strand | 457-463 | 7 | 23 |
| β-strand | 467-472 | 6 | 23 |
| β-strand | 476-480 | 5 | 23 |
| β-strand | 486-490 | 5 | 23 |
| β-strand | 500-503 | 4 | 24 |
| β-strand | 507-512 | 6 | 24 |
| β-strand | 515-521 | 7 | 24 |
| β-strand | 526-533 | 8 | 24 |
| β-strand | 538-542 | 5 | 25 |
| β-strand | 555-560 | 6 | 25 |
| β-strand | 567-570 | 4 | 25 |
| α-helix | 572-574 | 3 | |
| β-strand | 575 | 1 | 25 |
| β-strand | 588-595 | 8 | 26 |
| β-strand | 600-606 | 7 | 26 |
| β-strand | 610-615 | 6 | 26 |
| β-strand | 616-617 | 2 | 27 |
| β-strand | 622-623 | 2 | 27 |
| β-strand | 628-630 | 3 | 26 |
| β-strand | 637-642 | 6 | 28 |
| β-strand | 647-652 | 6 | 28 |
| β-strand | 657-661 | 5 | 28 |
| β-strand | 666-670 | 5 | 28 |
| β-strand | 671 | 1 | 20 |
| β-strand | 678-681 | 4 | 21 |
| β-strand | 691-694 | 4 | 21 |
| β-strand | 699-704 | 6 | 21 |
| β-strand | 711-716 | 6 | 19 |
| β-strand | 720-727 | 8 | 29 |
| β-strand | 732-744 | 13 | 29 |
| β-strand | 748-751 | 4 | 29 |
| β-strand | 763-765 | 3 | 29 |
| β-strand | 785-795 | 11 | 29 |
| β-strand | 801-806 | 6 | 29 |
| β-strand | 811-819 | 9 | 30 |
| β-strand | 828-835 | 8 | 30 |
| β-strand | 846-853 | 8 | 30 |
| β-strand | 858-866 | 9 | 30 |
| β-strand | 873-876 | 4 | 31 |
| β-strand | 879-883 | 5 | 31 |
| β-strand | 888-893 | 6 | 31 |
| β-strand | 899-905 | 7 | 31 |
| β-strand | 913-917 | 5 | 32 |
| β-strand | 920-924 | 5 | 32 |
| β-strand | 930-936 | 7 | 32 |
| β-strand | 941-944 | 4 | 32 |
| β-strand | 947 | 1 | 33 |
| β-strand | 956-961 | 6 | 34 |
| β-strand | 964-968 | 5 | 34 |
| β-strand | 974-979 | 6 | 34 |
| α-helix | 986-990 | 5 | |
| β-strand | 991 | 1 | 33 |
| β-strand | 992-998 | 7 | 34 |
| β-strand | 1004-1009 | 6 | 11 |
| β-strand | 1028-1032 | 5 | 11 |
| β-strand | 1037-1042 | 6 | 11 |
| α-helix | 1045-1061 | 17 | |
| α-helix | 1063-1064 | 2 | |
| β-strand | 1076-1077 | 2 | 35 |
| β-strand | 1082-1083 | 2 | 35 |
| β-strand | 1086 | 1 | 34 |
| β-strand | 1088-1090 | 3 | 11 |
| α-helix | 1091-1096 | 6 | |
| α-helix | 1097-1099 | 3 | |
| α-helix | 1102-1108 | 7 | |
| β-strand | 1113 | 1 | 36 |
| β-strand | 1123 | 1 | 36 |
| α-helix | 1126-1139 | 14 | |
Chain C: 5 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 59 | 1 | 37 |
| α-helix | 61-63 | 3 | |
| α-helix | 69-71 | 3 | |
| α-helix | 89-98 | 10 | |
| α-helix | 105-123 | 19 | |
| α-helix | 127-134 | 8 | |
| β-strand | 141 | 1 | 37 |
Chain D: 12 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 26-53 | 28 | |
| α-helix | 54-56 | 3 | |
| α-helix | 65-77 | 13 | |
| α-helix | 83-108 | 26 | |
| α-helix | 116-127 | 12 | |
| α-helix | 139-141 | 3 | |
| α-helix | 147-161 | 15 | |
| α-helix | 216-219 | 4 | |
| α-helix | 221-223 | 3 | |
| α-helix | 255-268 | 14 | |
| α-helix | 307-308 | 2 | |
| α-helix | 312-321 | 10 | |
Chain E: 13 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 82-99 | 18 | |
| β-strand | 107 | 1 | 38 |
| α-helix | 108-111 | 4 | |
| α-helix | 112-116 | 5 | |
| α-helix | 123-137 | 15 | |
| β-strand | 140-144 | 5 | 39 |
| β-strand | 151 | 1 | 38 |
| β-strand | 152-156 | 5 | 39 |
| α-helix | 159-161 | 3 | |
| α-helix | 177-188 | 12 | |
| β-strand | 193-194 | 2 | 40 |
| α-helix | 195-203 | 9 | |
| β-strand | 213 | 1 | 41 |
| β-strand | 217 | 1 | 41 |
| α-helix | 219-221 | 3 | |
| α-helix | 222-226 | 5 | |
| α-helix | 227-229 | 3 | |
| β-strand | 233 | 1 | 42 |
| β-strand | 236-237 | 2 | 40 |
| β-strand | 246-248 | 3 | 40 |
| β-strand | 250 | 1 | 42 |
| α-helix | 252-257 | 6 | |
| α-helix | 260-265 | 6 | |
| α-helix | 279-293 | 15 | |
Chain F: 14 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 13-25 | 13 | |
| β-strand | 27-29 | 3 | 43 |
| α-helix | 30-44 | 15 | |
| α-helix | 49-52 | 4 | |
| α-helix | 53-64 | 12 | |
| α-helix | 65-67 | 3 | |
| β-strand | 69-75 | 7 | 43 |
| β-strand | 82-88 | 7 | 43 |
| α-helix | 94-97 | 4 | |
| α-helix | 103-118 | 16 | |
| α-helix | 126-131 | 6 | |
| α-helix | 143-155 | 13 | |
| β-strand | 159-162 | 4 | 44 |
| β-strand | 165-168 | 4 | 44 |
| α-helix | 170-183 | 14 | |
| β-strand | 190 | 1 | 45 |
| β-strand | 197 | 1 | 45 |
| β-strand | 201-203 | 3 | 46 |
| α-helix | 204 | 1 | |
| β-strand | 210-212 | 3 | 46 |
| α-helix | 213-219 | 7 | |
| α-helix | 233-235 | 3 | |
| α-helix | 238-245 | 8 | |
Chain G: 43 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 51-52 | 2 | |
| α-helix | 55-57 | 3 | |
| α-helix | 59-73 | 15 | |
| α-helix | 74-76 | 3 | |
| α-helix | 83-93 | 11 | |
| α-helix | 99-118 | 20 | |
| α-helix | 119-121 | 3 | |
| α-helix | 128-152 | 25 | |
| α-helix | 154-156 | 3 | |
| α-helix | 157-161 | 5 | |
| α-helix | 168-169 | 2 | |
| α-helix | 170-181 | 12 | |
| α-helix | 187-203 | 17 | |
| α-helix | 211-223 | 13 | |
| α-helix | 227 | 1 | |
| α-helix | 228-232 | 5 | |
| α-helix | 233-253 | 21 | |
| α-helix | 256-277 | 22 | |
| α-helix | 280-282 | 3 | |
| α-helix | 283-294 | 12 | |
| α-helix | 299-304 | 6 | |
| α-helix | 307-313 | 7 | |
| α-helix | 316-328 | 13 | |
| α-helix | 330-353 | 24 | |
| α-helix | 356-359 | 4 | |
| α-helix | 361-375 | 15 | |
| α-helix | 376-380 | 5 | |
| α-helix | 384-398 | 15 | |
| α-helix | 404-417 | 14 | |
| β-strand | 418 | 1 | 47 |
| α-helix | 426-442 | 17 | |
| α-helix | 446-462 | 17 | |
| β-strand | 466 | 1 | 47 |
| α-helix | 469-479 | 11 | |
| α-helix | 485-515 | 31 | |
| β-strand | 525-529 | 5 | 48 |
| α-helix | 534-535 | 2 | |
| α-helix | 545-559 | 15 | |
| β-strand | 565-570 | 6 | 48 |
| β-strand | 575 | 1 | 49 |
| β-strand | 578-579 | 2 | 50 |
| β-strand | 582 | 1 | 51 |
| β-strand | 585 | 1 | 51 |
| β-strand | 588-589 | 2 | 50 |
| β-strand | 592 | 1 | 49 |
| α-helix | 593-601 | 9 | |
| α-helix | 602-604 | 3 | |
| α-helix | 610-617 | 8 | |
| α-helix | 621-629 | 9 | |
| β-strand | 639-641 | 3 | 52 |
| β-strand | 654-656 | 3 | 52 |
| β-strand | 667 | 1 | 50 |
| α-helix | 670-674 | 5 | |
| α-helix | 678-706 | 29 | |
| α-helix | 712-722 | 11 | |
| α-helix | 729-741 | 13 | |
| β-strand | 745-748 | 4 | 53 |
| β-strand | 751-757 | 7 | 53 |
Chain H: 1 helix, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 29-35 | 7 | 48 |
| α-helix | 54-57 | 4 | |
| β-strand | 70-71 | 2 | 54 |
| β-strand | 79-80 | 2 | 54 |
| β-strand | 93 | 1 | 55 |
| β-strand | 100 | 1 | 55 |
2 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Structural maintenance of chromosomes protein 6 | A | protein | 1091 | Homo sapiens | Q96SB8 (AlphaFold model) |
| DNA damage-binding protein 1 | B | protein | 1140 | Homo sapiens | Q16531 (AlphaFold model) |
| Protein X | C | protein | 154 | Hepatitis B virus | Q2F514 |
| EP300-interacting inhibitor of differentiation 3 | D | protein | 333 | Homo sapiens | Q8N140 (AlphaFold model) |
| Non-structural maintenance of chromosomes element 3 homolog | E | protein | 304 | Homo sapiens | Q96MG7 |
| Non-structural maintenance of chromosomes element 1 homolog | F | protein | 266 | Homo sapiens | Q8WV22 |
| Cullin-4A | G | protein | 760 | Homo sapiens | Q13619 |
| E3 ubiquitin-protein ligase RBX1 | H | protein | 108 | Homo sapiens | P62877 |
| Structural maintenance of chromosomes protein 5 | I | protein | 1101 | Homo sapiens | Q8IY18 |
| E3 SUMO-protein ligase NSE2 | J | protein | 247 | Homo sapiens | Q96MF7 |
Sequence of entity 1 (A), FASTA
>9LWL_1 Structural maintenance of chromosomes protein 6 (chains A)
MAKRKEENFSSPKNAKRPRQEELEDFDKDGDEDECKGTTLTAAEVGIIESIHLKNFMCHS
MLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVKDGQNSADIS
ITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSVVSTRKEELIAILDHFNI
QVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQG
EERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIG
EDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAY
NEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAF
QNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRF
GPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHA
DERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVAN
SLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFL
SRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKN
ISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKY
DAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKE
KELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARE
TYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNF
DHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVY
MDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFR
PVTQEEDDDQR
Sequence of entity 2 (B), FASTA
>9LWL_2 DNA damage-binding protein 1 (chains B)
MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGK
IAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDIITRAHGNVQDRIGRPSETGI
IGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQAPTICF
VYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYH
NGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDL
RVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIV
DMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDPNRE
TDDTLVLSFVGQTRVLMLNGEEVEETELMGFVDDQQTFFCGNVAHQQLIQITSASVRLVS
QEPKALVSEWKEPQAKNISVASCNSSQVVVAVGRALYYLQIHPQELRQISHTEMEHEVAC
LDITPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSH
YLLCALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIY
SSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYES
PRKICYQEVSQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHET
SFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEE
AEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELR
TECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEIL
DDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGET
STPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTER
KTEPATGFIDGDLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH
Sequence of entity 3 (C), FASTA
>9LWL_3 Protein X (chains C)
MAARLCCQLDPARDVLCLRPVGAESCGRPFSGSLGTLSSPSPSAVPTDHGAHLSLRGLPV
CAFSSAGPCALRFTSARRMETTVNAHQILPKVLHKRTLGLSAMSTTDLEAYFKDCLFKDW
EELGEEIRLKVFVLGGCRHKLVCAPAPCNFFTSA
Sequence of entity 4 (D), FASTA
>9LWL_4 EP300-interacting inhibitor of differentiation 3 (chains D)
MKMDVSVRAAGCSDDLSSGEADVDPKLLELTADEEKCRSIRRQYRQLMYCVRQNREDIVS
SANNSLTEALEEANVLFDGVSRTREAALDARFLVMASDLGKEKAKQLNSDMNFFNQLAFC
DFLFLFVGLNWMEGDPDKLSDCDDSIALSFWKAIEKEATSWMVKAETFHFVFGSFKLERS
APKPRLEHQKKVRKMEENGNMPTKLQKLDLSSYPEATEKNVERILGLLQTYFRKYPDTPV
SYFEFVIDPNSFSRTVENIFYVSFIVRDGFARIRLDEDRLPILEPMNVNQMGEGNDSSCH
GRKQGVISLTLQEWKNIVAAFEISEAMITYSSY
Sequence of entity 5 (E), FASTA
>9LWL_5 Non-structural maintenance of chromosomes element 3 homolog (chains E)
MLQKPRNRGRSGGQAERDRDWSHSGNPGASRAGEDARVLRDGFAEEAPSTSRGPGGSQGS
QGPSPQGARRAQAAPAVGPRSQKQLELKVSELVQFLLIKDQKKIPIKRADILKHVIGDYK
DIFPDLFKRAAERLQYVFGYKLVELEPKSNTYILINTLEPVEEDAEMRGDQGTPTTGLLM
IVLGLIFMKGNTIKETEAWDFLRRLGVYPTKKHLIFGDPKKLITEDFVRQRYLEYRRIPH
TDPVDYEFQWGPRTNLETSKMKVLKFVAKVHNQDPKDWPAQYCEALADEENRARPQPSGP
APSS
Sequence of entity 6 (F), FASTA
>9LWL_6 Non-structural maintenance of chromosomes element 1 homolog (chains F)
MQGSTRRMGVMTDVHRRFLQLLMTHGVLEEWDVKRLQTHCYKVHDRNATVDKLEDFINNI
NSVLESLYIEIKRGVTEDDGRPIYALVNLATTSISKMATDFAENELDLFRKALELIIDSE
TGFASSTNILNLVDQLKGKKMRKKEAEQVLQKFVQNKWLIEKEGEFTLHGRAILEMEQYI
RETYPDAVKICNICHSLLIQGQSCETCGIRMHLPCVAKYFQSNAEPRCPHCNDYWPHEIP
KVFDPEKERESGVLKSNKKSLRSRQH
Sequence of entity 7 (G), FASTA
>9LWL_7 Cullin-4A (chains G)
MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQ
DTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILP
FREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRT
HIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETN
CLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLT
AILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKD
MVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAG
NKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLK
HECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPME
VHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLL
MFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEF
KHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELY
NQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVAG
Sequence of entity 8 (H), FASTA
>9LWL_8 E3 ubiquitin-protein ligase RBX1 (chains H)
MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQ
ASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH
Sequence of entity 9 (I), FASTA
>9LWL_9 Structural maintenance of chromosomes protein 5 (chains I)
MATPSKKTSTPSPQPSKRALPRDPSSEVPSKRKNSAPQLPLLQSSGPFVEGSIVRISMEN
FLTYDICEVSPGPHLNMIVGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVKRGCSR
GMVEIELFRASGNLVITREIDVAKNQSFWFINKKSTTQKIVEEKVAALNIQVGNLCQFLP
QDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMV
QRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLK
EGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALI
VKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGE
IIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQR
VCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIA
PKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERI
ERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLK
EIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKL
MEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISE
KNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQ
TQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEI
EQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHT
ENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDE
INQGMDPINERRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVLFVYNGPHMLEP
NTWNLKAFQRRRRRITFTQPS
Sequence of entity 10 (J), FASTA
>9LWL_10 E3 SUMO-protein ligase NSE2 (chains J)
MPGRSSSNSGSTGFISFSGVESALSSLKNFQACINSGMDTASSVALDLVESQTEVSSEYS
MDKAMVEFATLDRQLNHYVKAVQSTINHVKEERPEKIPDLKLLVEKKFLALQSKNSDADF
QNNEKFVQFKQQLKELKKQCGLQADREADGTEGVDEDIIVTQSQTNFTCPITKEEMKKPV
KNKVCGHTYEEDAIVRMIESRQKRKKKAYCPQIGCSHTDIRKSDLIQDEALRRAIENHNK
KRHRHSE
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 6 |
Primary citation
Structural and functional insights into HBx-Smc6 targeting for HBV inhibition. Cheng, T., Zhou, J., Huang, W. et al. Cell Res (2026) 36:629-632. DOI 10.1038/s41422-026-01251-7 · PubMed
Other PDB entries of the same protein (UniProt Q96SB8 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 9LWI 3.12 Å, The head region of HBx-Smc5/6 ubiquitination complex
- 9LWJ 7.19 Å, The head-arm region of HBx-Smc5/6 ubiquitination complex
- 9LWK 7.32 Å, The hinge-arm region of HBx-Smc5/6 ubiquitination complex
Browse structure collections
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