Crystal Structure of kelch domain of human KEAP1 in complex with CH7450924. Determined by X-ray diffraction at 1.57 Å resolution. Released 29 Oct 2025.
Explore 9M24 in 3D Show helices and sheets RCSB PDB PDBe
9M24 contains 5 α-helices and 40 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 328-331 | 4 | 1 |
| β-strand | 334-335 | 2 | 2 |
| β-strand | 337-338 | 2 | 2 |
| β-strand | 342-345 | 4 | 1 |
| β-strand | 352-354 | 3 | 1 |
| α-helix | 356-358 | 3 | |
| β-strand | 363 | 1 | 3 |
| β-strand | 366-370 | 5 | 4 |
| β-strand | 373-377 | 5 | 4 |
| β-strand | 380-383 | 4 | 3 |
| β-strand | 386-389 | 4 | 3 |
| β-strand | 393-397 | 5 | 4 |
| β-strand | 402-405 | 4 | 4 |
| α-helix | 407-409 | 3 | |
| β-strand | 414 | 1 | 5 |
| β-strand | 417-421 | 5 | 6 |
| β-strand | 424-428 | 5 | 6 |
| β-strand | 431-432 | 2 | 5 |
| β-strand | 435-436 | 2 | 5 |
| β-strand | 440-444 | 5 | 6 |
| β-strand | 449-453 | 5 | 6 |
| α-helix | 454-456 | 3 | |
| β-strand | 461 | 1 | 7 |
| β-strand | 464-468 | 5 | 7 |
| β-strand | 471-478 | 8 | 7 |
| β-strand | 483-491 | 9 | 7 |
| β-strand | 496-500 | 5 | 7 |
| α-helix | 501-503 | 3 | |
| β-strand | 508 | 1 | 8 |
| β-strand | 511-515 | 5 | 9 |
| β-strand | 518-522 | 5 | 9 |
| β-strand | 525 | 1 | 8 |
| β-strand | 530 | 1 | 8 |
| β-strand | 534-538 | 5 | 9 |
| β-strand | 543-547 | 5 | 9 |
| α-helix | 548-550 | 3 | |
| β-strand | 555 | 1 | 10 |
| β-strand | 558-562 | 5 | 11 |
| β-strand | 565-569 | 5 | 11 |
| β-strand | 572 | 1 | 10 |
| β-strand | 577 | 1 | 10 |
| β-strand | 580-585 | 6 | 11 |
| β-strand | 590-596 | 7 | 11 |
| β-strand | 602 | 1 | 2 |
| β-strand | 605-608 | 4 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Kelch-like ECH-associated protein 1 | A | protein | 293 | Homo sapiens | Q14145 (AlphaFold model) |
>9M24_1 Kelch-like ECH-associated protein 1 (chains A) GSHMAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYA VGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIH HNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNE WRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVATATWTFVAPMKHRRSA LGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
| ID | Name | Formula | Copies |
|---|---|---|---|
| A1L8K | 4-[3-[2-chloro-4-[(2R,5R)-2,4,5-trimethylpiperazin-1-yl]benzoyl]-2,4-dihydro-1,… | C35 H38 Cl F N4 O5 | 1 |
Water and common crystallization additives (DMS, ACT) are not listed.
CH7450924, a KEAP1-NRF2 interaction inhibitor, ameliorates LPS-induced multiple organ dysfunction via inflammatory pathway inhibition. Hoshino, M., Yasui, Y., Mitsumata, S. et al. Sci Rep (2025) 15:36413-36413. DOI 10.1038/s41598-025-20350-w · PubMed
Other PDB entries of the same protein (UniProt Q14145 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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