Crystal Structure of 19b Fab bound to the third variable (V3) loop peptide from the HIV-1 JR-FL envelope (Env) glycoprotein. Determined by X-ray diffraction at 1.78 Å resolution. Released 21 Jan 2026.
Explore 9MMJ in 3D Show helices and sheets RCSB PDB PDBe
9MMJ contains 18 α-helices and 44 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 4-7 | 4 | 1 |
| β-strand | 10-13 | 4 | 2 |
| β-strand | 18-25 | 8 | 1 |
| β-strand | 33-38 | 6 | 2 |
| β-strand | 45-49 | 5 | 2 |
| α-helix | 53-55 | 3 | |
| β-strand | 62-66 | 5 | 1 |
| β-strand | 70-76 | 7 | 1 |
| α-helix | 80-82 | 3 | |
| β-strand | 84-90 | 7 | 2 |
| α-helix | 96 | 1 | |
| β-strand | 97-98 | 2 | 2 |
| β-strand | 102-106 | 5 | 2 |
| β-strand | 111 | 1 | 3 |
| α-helix | 112-113 | 2 | |
| β-strand | 114-118 | 5 | 4 |
| α-helix | 119-121 | 3 | |
| α-helix | 122-125 | 4 | |
| β-strand | 129-139 | 11 | 4 |
| β-strand | 140 | 1 | 3 |
| β-strand | 145-150 | 6 | 5 |
| β-strand | 153-154 | 2 | 5 |
| β-strand | 159-163 | 5 | 4 |
| α-helix | 164-167 | 4 | |
| β-strand | 173-182 | 10 | 4 |
| α-helix | 183-188 | 6 | |
| β-strand | 191-197 | 7 | 5 |
| β-strand | 205-210 | 6 | 5 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 3-6 | 4 | 6 |
| α-helix | 7-9 | 3 | |
| β-strand | 10-12 | 3 | 2 |
| β-strand | 18-25 | 8 | 6 |
| α-helix | 29-31 | 3 | |
| β-strand | 34-40 | 7 | 2 |
| β-strand | 44-51 | 8 | 2 |
| β-strand | 57-59 | 3 | 2 |
| α-helix | 61-63 | 3 | |
| β-strand | 67-72 | 6 | 6 |
| β-strand | 77-82 | 6 | 6 |
| α-helix | 84-86 | 3 | |
| β-strand | 88-94 | 7 | 2 |
| β-strand | 102-103 | 2 | 2 |
| β-strand | 107-111 | 5 | 2 |
| α-helix | 115-116 | 2 | |
| β-strand | 117 | 1 | 7 |
| α-helix | 118-119 | 2 | |
| β-strand | 120-124 | 5 | 8 |
| β-strand | 135-145 | 11 | 8 |
| β-strand | 146 | 1 | 7 |
| β-strand | 151-154 | 4 | 9 |
| α-helix | 155-157 | 3 | |
| β-strand | 159 | 1 | 9 |
| β-strand | 163-165 | 3 | 8 |
| α-helix | 166-168 | 3 | |
| β-strand | 169-170 | 2 | 8 |
| β-strand | 176-185 | 10 | 8 |
| α-helix | 186-188 | 3 | |
| β-strand | 195-200 | 6 | 9 |
| α-helix | 201-203 | 3 | |
| β-strand | 205-210 | 6 | 9 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 307-312 | 6 | 10 |
| β-strand | 315-319 | 5 | 10 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| 19b Fab Light Chain | A | protein | 213 | Homo sapiens | |
| 19b Fab Heavy Chain | B | protein | 216 | Homo sapiens | |
| Surface protein gp120 JR-FL V3 peptide | D | protein | 43 | Human immunodeficiency virus 1 | P20871 |
>9MMJ_1 19b Fab Light Chain (chains A) DIVLTQSPPSLSASVGDRVTITCQASQDISDHLSWFQQKPGKAPKLLVYGVSSLEAGVPS RFSVSGSGTHFTFTVNGLQPEDLATYFCQQYDDLPWTFGPGTVVEVKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
>9MMJ_2 19b Fab Heavy Chain (chains B) EVQLVQSGGALIQPGGSLRLSCAASGFTFVDYAMSWVRQAPGKGLQWVSTIIGSGADTYY TDSVKGRFTISRDNSNNTVHLQMNSLRADDTALYYCVRGVFDLWGQGTLVTVSSASTKGP SVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLS SVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKS
>9MMJ_3 Surface protein gp120 JR-FL V3 peptide (chains D) EINCTRPNNNTRKSIHIGPGRWFYTTGEIIGDIRQAHCNISRA
Structural determination of the HIV-1 Variable Region 3 epitope of antibody 19b. Fetics, S.K., Mehta, A., Nicely, N.I. et al. J Virol (2026) 100:e0213925-e0213925. DOI 10.1128/jvi.02139-25 · PubMed
Other PDB entries of the same protein (UniProt P20871), best resolution first:
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