9MMU: M5 protein with Factor H 6-7 domain

M5 protein with Factor H 6-7 domain. Determined by X-ray diffraction at 2.25 Å resolution. Released 4 Feb 2026.

Method: X-ray diffraction
Resolution: 2.25 Å
Organisms: Streptococcus pyogenes str. Manfredo, Homo sapiens
Chains: 8
Atoms: 4,614
Mol. weight: 97.68 kDa
Released: 4 Feb 2026

Explore 9MMU in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9MMU contains 9 α-helices and 53 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	103-151	49

Chains B and F: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	108-152	45

Chain C: 2 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	325	1	1
β-strand	333-335	3	2
β-strand	347	1	1
β-strand	352-357	6	2
β-strand	361-362	2	3
β-strand	369-375	7	2
β-strand	378-380	3	2
β-strand	386-387	2	3
β-strand	388-390	3	4
α-helix	391	1
β-strand	397	1	5
β-strand	405-407	3	4
β-strand	411-413	3	6
β-strand	416	1	5
α-helix	417	1
β-strand	428-432	5	6
β-strand	435-437	3	6

Chain D: 1 helix, 11 β-strands

Element	Residues	Length	Sheet
β-strand	353-356	4	7
β-strand	361-362	2	8
β-strand	369-372	4	7
β-strand	386-387	2	8
β-strand	389-390	2	9
α-helix	391	1
β-strand	397	1	10
β-strand	405-406	2	9
β-strand	411-413	3	11
β-strand	416	1	10
β-strand	428-432	5	11
β-strand	435-437	3	11

Chain E: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	106-153	48

Chain G: 1 helix, 15 β-strands

Element	Residues	Length	Sheet
β-strand	325	1	12
β-strand	333-335	3	13
β-strand	347	1	12
β-strand	352-357	6	13
β-strand	361-362	2	14
β-strand	369-375	7	13
β-strand	378-380	3	13
β-strand	386-387	2	14
β-strand	388-390	3	15
β-strand	397	1	16
β-strand	405-407	3	15
β-strand	411-413	3	17
β-strand	416	1	16
α-helix	417	1
β-strand	428-432	5	17
β-strand	435-437	3	17

Chain H: 1 helix, 12 β-strands

Element	Residues	Length	Sheet
β-strand	352-356	5	18
β-strand	361-362	2	19
β-strand	369-373	5	18
α-helix	374	1
β-strand	380	1	18
β-strand	386-387	2	19
β-strand	390	1	20
β-strand	397	1	21
β-strand	405	1	20
β-strand	411-413	3	22
β-strand	416	1	21
β-strand	428-432	5	22
β-strand	435-437	3	22

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
M protein, serotype 5	A, B, E, F	protein	86	Streptococcus pyogenes str. Manfredo	P02977 (AlphaFold model)
Complement factor H	C, D, G, H	protein	125	Homo sapiens	P08603 (AlphaFold model)

Sequence of entity 1 (A, B, E, F), FASTA

>9MMU_1 M protein, serotype 5 (chains A, B, E, F)
GPGSNEGLKTEKKEHEAENDKLKQQRDTLSTQKETLEREVQNTQYNNETLKIKNGDLTKE
LNKTRQELANKQQESKENEKALNELL

Sequence of entity 2 (C, D, G, H), FASTA

>9MMU_2 Complement factor H (chains C, D, G, H)
MGTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG
WSPAVPCLRKCYFPYLENGYNQNYGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSP
TPRCI

Primary citation

Structural mechanisms for the recruitment of factor H by Streptococcus pyogenes. Kumar, A., Wang, K.C., Ghosh, P. Structure (2026) 34:778. DOI 10.1016/j.str.2026.02.010 · PubMed

Other PDB entries of the same protein (UniProt P02977 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2KK9 Anti-group A streptococcal vaccine epitope: structure, stability and its ability to…

Browse structure collections

About this viewer

MolViewer shows 9MMU directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.