9NJ2: Neuraminidase

N1 neuraminidase of influenza A/Vietnam/1203/2004 H5N1 in complex with four FNI9 Fab molecules. Determined by electron microscopy at 2.4 Å resolution. Released 11 Mar 2026.

Method: Electron microscopy
Resolution: 2.4 Å
Organisms: Influenza A virus (A/Viet Nam/1203/2004(H5N1)), Homo sapiens
Chains: 12
Atoms: 19,073
Mol. weight: 312.71 kDa
Ligands: CA, NAG
Released: 11 Mar 2026

Explore 9NJ2 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9NJ2 contains 60 α-helices and 208 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, B, C and D: 7 helices, 28 β-strands

Element	Residues	Length	Sheet
β-strand	91	1	1
α-helix	92-93	2
β-strand	96-102	7	2
α-helix	105-108	4
β-strand	115-124	10	3
β-strand	129-139	11	3
α-helix	143-145	3
β-strand	157-162	6	3
α-helix	172	1
β-strand	173-177	5	3
β-strand	180-185	6	4
β-strand	190-196	7	4
β-strand	203-208	6	4
β-strand	211-217	7	4
β-strand	225	1	5
β-strand	230	1	4
α-helix	231	1
β-strand	232-234	3	5
β-strand	237-244	8	5
β-strand	252-259	8	5
β-strand	262-268	7	5
β-strand	277-284	8	6
β-strand	287-293	7	6
β-strand	302-306	5	6
β-strand	312-316	5	6
α-helix	328-329	2
β-strand	350-353	4	7
β-strand	356-361	6	7
β-strand	369-376	8	7
β-strand	389-399	11	7
β-strand	403-408	6	2
α-helix	410-413	4
β-strand	418	1	1
β-strand	419-429	11	2
β-strand	438-448	11	2

Chains H, I, J and K: 5 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	4-6	3	29
α-helix	7-9	3
β-strand	10-12	3	30
β-strand	18-24	7	29
α-helix	32-33	2
β-strand	34-39	6	30
β-strand	46-51	6	30
β-strand	58-60	3	30
α-helix	62-64	3
β-strand	68-73	6	29
α-helix	74-76	3
β-strand	78-83	6	29
α-helix	88-90	3
β-strand	92-99	8	30
β-strand	104-105	2	31
β-strand	109-110	2	31
β-strand	115-118	4	30
β-strand	122-126	5	30

Chains L, M, N and O: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	41
β-strand	10-13	4	42
α-helix	17-18	2
β-strand	19-25	7	41
β-strand	33-38	6	42
β-strand	45-49	5	42
β-strand	53-54	2	42
β-strand	62-67	6	41
β-strand	70-75	6	41
α-helix	80-82	3
β-strand	84-90	7	42
α-helix	96-97	2
β-strand	98-99	2	42
β-strand	103-107	5	42

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Neuraminidase	A, B, C, D	protein	470	Influenza A virus (A/Viet Nam/1203/2004(H5N1))	Q6DPL2
FNI9 Fab heavy chain	H, I, J, K	protein	128	Homo sapiens
FNI9 Fab light chain	L, M, N, O	protein	108	Homo sapiens

Sequence of entity 1 (A, B, C, D), FASTA

>9NJ2_1 Neuraminidase (chains A, B, C, D)
HHHHHHGSGLNDIFEAQKIEWHEGSIINETADDIVYRLTVIIDDRYESLKNLITLRADRL
EMIINDNVSTILASGLVPRGSGSVKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIRE
PFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCPVGEAPSPYNSRFESVAW
SASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCF
TVMTDGPSNGQASHKIFKMEKGKVVKSVELDAPNYHYEECSCYPNAGEITCVCRDNWHGS
NRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWI
GRTKSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIR
PCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK

Sequence of entity 2 (H, I, J, K), FASTA

>9NJ2_2 FNI9 Fab heavy chain (chains H, I, J, K)
QVHLVQSGAEVKEPGSSVTVSCKASGGSFNNQAISWVRQAPGQGLEWMGGIFPISGTPTS
AQRFQGRVTFTADESTTTVYMDLSSLRSDDTAVYYCARAGSDYFNRDLGWENYYFASWGQ
GTLVTVSS

Sequence of entity 3 (L, M, N, O), FASTA

>9NJ2_3 FNI9 Fab light chain (chains L, M, N, O)
EIVMTQSPATLSLSSGERATLSCRASRSVSSNLAWYQQKPGQAPRLLIYDASTRATGFSA
RFAGSGSGTEFTLTISSLQSEDSAIYYCQQYNNWPPWTFGQGTKVEIK

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	9
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	12

Primary citation

Potent efficacy of an NA-targeting antibody against a broad spectrum of H5N1 influenza viruses. Moriyama, S., di Iulio, J., Zatta, F. et al. Nat Commun (2026) 17. DOI 10.1038/s41467-026-70036-8 · PubMed

Other PDB entries of the same protein (UniProt Q6DPL2), best resolution first:

3CKZ 1.9 Å, N1 Neuraminidase H274Y + Zanamivir
3CL0 2.2 Å, N1 Neuraminidase H274Y + oseltamivir
2HTY 2.5 Å, N1 neuraminidase
2HU4 2.5 Å, N1 neuraminidase in complex with oseltamivir 2
3CL2 2.54 Å, N1 Neuraminidase N294S + Oseltamivir
2HU0 2.95 Å, N1 neuraminidase in complex with oseltamivir 1

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