9O5A: The KICSTOR-GATOR1 complex

The KICSTOR-GATOR1 complex. Determined by electron microscopy at 3.2 Å resolution. Released 18 Feb 2026.

Method: Electron microscopy
Resolution: 3.2 Å
Organism: Homo sapiens
Chains: 7
Atoms: 42,618
Mol. weight: 829.22 kDa
Released: 18 Feb 2026

Explore 9O5A in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9O5A contains 254 α-helices and 270 β-strands across 7 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain B: 47 helices, 62 β-strands

Element	Residues	Length	Sheet
β-strand	7-12	6	8
β-strand	23-24	2	8
β-strand	25	1	9
β-strand	38-41	4	10
β-strand	51-54	4	10
β-strand	58	1	9
α-helix	63	1
β-strand	66-70	5	8
α-helix	71-76	6
β-strand	84-85	2	8
β-strand	88-89	2	10
β-strand	96	1	11
β-strand	99-104	6	12
α-helix	111-121	11
β-strand	124-127	4	11
β-strand	131-134	4	12
β-strand	137-146	10	12
β-strand	149-150	2	12
β-strand	151	1	13
β-strand	153-156	4	11
β-strand	161-166	6	12
β-strand	170-176	7	14
α-helix	179-182	4
β-strand	184	1	15
β-strand	190	1	15
α-helix	191-193	3
α-helix	194-200	7
α-helix	201-209	9
β-strand	215-226	12	14
α-helix	231-233	3
α-helix	239-241	3
β-strand	242-244	3	14
β-strand	250-262	13	14
α-helix	268-284	17
β-strand	296-298	3	14
α-helix	299-300	2
α-helix	306-318	13
β-strand	322	1	16
β-strand	331-337	7	14
β-strand	342-345	4	17
α-helix	347-360	14
β-strand	363-368	6	14
α-helix	371-372	2
β-strand	379-382	4	17
β-strand	396-398	3	17
β-strand	404-407	4	14
α-helix	425-427	3
β-strand	428	1	4
α-helix	429-430	2
α-helix	459-467	9
α-helix	730-734	5
α-helix	735-737	3
α-helix	744-748	5
α-helix	750	1
β-strand	751	1	12
α-helix	752-754	3
β-strand	756-757	2	18
α-helix	763-769	7
β-strand	770-777	8	18
α-helix	792-794	3
α-helix	795-809	15
β-strand	812-814	3	18
β-strand	851-856	6	18
β-strand	859-865	7	18
β-strand	870-877	8	18
β-strand	886-893	8	14
α-helix	900-901	2
β-strand	902-908	7	14
α-helix	913-915	3
α-helix	918-926	9
α-helix	937-939	3
β-strand	942-950	9	16
α-helix	953-960	8
α-helix	979-994	16
β-strand	1172	1	19
α-helix	1177-1184	8
β-strand	1194	1	20
α-helix	1200-1201	2
β-strand	1204-1206	3	20
α-helix	1207-1217	11
β-strand	1219	1	19
α-helix	1224-1236	13
β-strand	1240-1242	3	20
β-strand	1254-1255	2	21
β-strand	1257-1260	4	20
α-helix	1287-1292	6
β-strand	1296-1298	3	21
α-helix	1310-1312	3
β-strand	1351-1357	7	16
β-strand	1369-1375	7	16
β-strand	1377-1378	2	21
β-strand	1382-1383	2	22
β-strand	1384-1390	7	16
α-helix	1395-1411	17
β-strand	1414-1419	6	16
β-strand	1439-1442	4	22
α-helix	1445-1447	3
α-helix	1450	1
α-helix	1462-1464	3
α-helix	1465-1479	15
β-strand	1482-1485	4	22
β-strand	1501-1504	4	22
β-strand	1509-1512	4	22
β-strand	1545-1550	6	22
α-helix	1556-1558	3
α-helix	1561-1563	3
α-helix	1568-1580	13
α-helix	1583-1585	3
α-helix	1586-1596	11

Chain C: 28 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	9-15	7	1
β-strand	21-26	6	1
β-strand	47	1	13
α-helix	61-63	3
α-helix	66-73	8
α-helix	77-79	3
β-strand	84-88	5	1
β-strand	91-95	5	1
β-strand	98-99	2	1
β-strand	123-131	9	1
α-helix	136-160	25
α-helix	162-179	18
α-helix	190-197	8
α-helix	199-213	15
β-strand	216-221	6	67
β-strand	225-230	6	67
α-helix	232-235	4
α-helix	242-244	3
α-helix	245-253	9
β-strand	260-263	4	68
α-helix	267-271	5
α-helix	280-288	9
α-helix	295-302	8
α-helix	306-318	13
β-strand	322-325	4	68
α-helix	326-328	3
β-strand	333-336	4	69
α-helix	347-355	9
α-helix	361-367	7
β-strand	372-373	2	69
α-helix	374-377	4
α-helix	384-399	16
β-strand	403-412	10	69
α-helix	481-488	8
α-helix	492-499	8
α-helix	502-505	4
α-helix	507-515	9
α-helix	517-519	3
β-strand	521-525	5	69
α-helix	526-533	8
α-helix	537-546	10
β-strand	551-557	7	69
α-helix	559-562	4
α-helix	563-565	3

Chain D: 115 helices, 110 β-strands

Element	Residues	Length	Sheet
β-strand	13-18	6	23
α-helix	26-35	10
β-strand	40-41	2	24
α-helix	43-45	3
α-helix	46-49	4
β-strand	56-62	7	23
β-strand	77-78	2	24
β-strand	84-89	6	23
β-strand	91-99	9	25
α-helix	102-105	4
β-strand	107	1	26
β-strand	114	1	26
α-helix	115-131	17
β-strand	134-135	2	27
β-strand	142-143	2	27
β-strand	146-154	9	25
β-strand	157	1	28
β-strand	165-167	3	25
β-strand	168	1	29
β-strand	169-171	3	25
α-helix	174-176	3
α-helix	177-203	27
β-strand	230	1	28
α-helix	233-248	16
β-strand	256-263	8	25
α-helix	272-285	14
β-strand	287-293	7	25
α-helix	310-319	10
β-strand	324-325	2	25
α-helix	328-332	5
α-helix	340-341	2
α-helix	342-346	5
β-strand	348	1	23
α-helix	375-379	5
β-strand	386-395	10	30
α-helix	399-408	10
β-strand	412-419	8	30
β-strand	424-434	11	30
β-strand	437-446	10	30
α-helix	450-452	3
β-strand	457-465	9	30
α-helix	467-474	8
α-helix	484-511	28
α-helix	513-515	3
α-helix	517-519	3
α-helix	524-527	4
β-strand	533-534	2	31
β-strand	543-544	2	31
α-helix	555-566	12
α-helix	573-576	4
β-strand	577-586	10	31
α-helix	587-588	2
α-helix	592	1
α-helix	605-609	5
α-helix	611-624	14
β-strand	627-630	4	31
β-strand	634-639	6	31
β-strand	649-656	8	31
β-strand	661-669	9	31
α-helix	674-689	16
β-strand	739-742	4	31
α-helix	746-749	4
α-helix	765-767	3
α-helix	786-792	7
β-strand	794-798	5	32
β-strand	801-802	2	33
α-helix	808-811	4
α-helix	812-828	17
β-strand	832-837	6	32
β-strand	840-849	10	32
β-strand	863-871	9	32
α-helix	872-874	3
β-strand	875-876	2	33
β-strand	902-903	2	33
β-strand	906-910	5	32
β-strand	913	1	29
α-helix	922-927	6
α-helix	934-961	28
β-strand	986-987	2	32
β-strand	990	1	33
α-helix	995-1001	7
β-strand	1003-1010	8	34
α-helix	1027-1038	12
α-helix	1039-1043	5
α-helix	1046	1
β-strand	1047-1049	3	34
α-helix	1053-1068	16
α-helix	1119-1121	3
β-strand	1122-1130	9	34
β-strand	1133-1140	8	34
α-helix	1143-1152	10
β-strand	1236-1245	10	34
α-helix	1246-1254	9
α-helix	1256	1
α-helix	1259-1262	4
β-strand	1265-1266	2	34
α-helix	1280-1282	3
α-helix	1284-1286	3
α-helix	1287-1313	27
α-helix	1327-1329	3
β-strand	1334-1338	5	35
α-helix	1340-1346	7
α-helix	1348-1351	4
β-strand	1416	1	36
α-helix	1417-1422	6
α-helix	1426-1428	3
α-helix	1429-1446	18
β-strand	1457	1	37
β-strand	1460	1	37
β-strand	1570-1573	4	35
α-helix	1575-1577	3
β-strand	1580-1582	3	35
α-helix	1591-1595	5
β-strand	1606	1	36
α-helix	1609-1611	3
β-strand	1614-1619	6	35
α-helix	1684-1708	25
α-helix	1709-1712	4
α-helix	1717-1728	12
β-strand	1736-1742	7	38
α-helix	1753-1760	8
β-strand	1765	1	39
β-strand	1768	1	39
β-strand	1769-1772	4	38
β-strand	1778-1782	5	38
β-strand	1917-1924	8	38
β-strand	1927-1934	8	38
α-helix	1945-1978	34
α-helix	2037-2039	3
β-strand	2040-2046	7	40
α-helix	2050-2053	4
α-helix	2062-2071	10
α-helix	2072-2074	3
β-strand	2075	1	40
β-strand	2082-2086	5	40
β-strand	2093-2100	8	40
β-strand	2159-2165	7	40
α-helix	2171	1
α-helix	2172-2177	6
α-helix	2178-2196	19
β-strand	2203	1	41
α-helix	2205-2211	7
α-helix	2216-2218	3
β-strand	2220-2225	6	42
α-helix	2228-2233	6
α-helix	2234-2248	15
β-strand	2250	1	42
β-strand	2254	1	41
α-helix	2259-2261	3
β-strand	2278-2283	6	42
β-strand	2293-2301	9	42
β-strand	2302	1	43
α-helix	2307	1
β-strand	2308	1	43
α-helix	2309	1
α-helix	2311-2313	3
α-helix	2322-2324	3
α-helix	2327-2333	7
β-strand	2337-2338	2	42
β-strand	2355-2363	9	42
α-helix	2367-2386	20
α-helix	2387-2391	5
β-strand	2397	1	44
α-helix	2501-2511	11
β-strand	2518	1	44
α-helix	2520	1
α-helix	2521-2525	5
α-helix	2526-2535	10
β-strand	2541-2547	7	45
α-helix	2551-2553	3
α-helix	2554-2568	15
β-strand	2573-2579	7	45
α-helix	2580	1
β-strand	2588-2591	4	45
α-helix	2593-2595	3
β-strand	2607-2613	7	45
α-helix	2615-2618	4
β-strand	2627	1	46
β-strand	2630	1	46
β-strand	2649-2655	7	45
β-strand	2658-2664	7	45
β-strand	2666	1	46
α-helix	2668-2699	32
α-helix	2729-2734	6
α-helix	2738-2739	2
α-helix	2764-2766	3
α-helix	2789	1
α-helix	2790-2794	5
α-helix	2795-2822	28
β-strand	2832	1	47
α-helix	2834-2842	9
β-strand	2845-2853	9	48
α-helix	2858-2861	4
α-helix	2907-2927	21
β-strand	2930-2931	2	48
β-strand	2934	1	47
β-strand	2981-2987	7	48
β-strand	2990-2999	10	48
β-strand	3002-3010	9	48
α-helix	3024-3039	16
α-helix	3042-3059	18
α-helix	3066	1
α-helix	3071-3081	11
β-strand	3092-3101	10	49
α-helix	3107-3116	10
α-helix	3119-3121	3
β-strand	3124-3129	6	49
β-strand	3137-3147	11	49
β-strand	3151	1	50
β-strand	3159	1	50
β-strand	3163-3171	9	49
α-helix	3182-3185	4
β-strand	3186-3197	12	49
α-helix	3249-3282	34
α-helix	3285-3286	2
α-helix	3301-3308	8
β-strand	3312-3315	4	51
α-helix	3316-3319	4
α-helix	3321-3328	8
α-helix	3331-3344	14
β-strand	3349-3353	5	51
β-strand	3360-3364	5	51
β-strand	3372-3378	7	51
β-strand	3385-3391	7	51
α-helix	3409-3429	21

Chain E: 13 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	10-12	3
β-strand	14-21	8	52
β-strand	31-32	2	53
β-strand	41-44	4	53
β-strand	50-58	9	53
β-strand	61-69	9	53
β-strand	79-87	9	54
α-helix	88-89	2
β-strand	95-103	9	54
β-strand	110-117	8	54
α-helix	123-125	3
α-helix	127-132	6
β-strand	134-138	5	54
β-strand	146-152	7	55
β-strand	157-163	7	55
β-strand	171-176	6	55
β-strand	181-185	5	55
α-helix	187-189	3
α-helix	192-194	3
β-strand	201-208	8	56
β-strand	214-221	8	56
β-strand	225-232	8	56
β-strand	238-245	8	56
β-strand	250-257	8	57
β-strand	273-279	7	57
α-helix	283-284	2
β-strand	285-287	3	57
α-helix	290-293	4
α-helix	294-296	3
β-strand	298-300	3	57
β-strand	310-316	7	58
β-strand	325-330	6	58
β-strand	334-340	7	58
α-helix	343-345	3
α-helix	349-351	3
β-strand	354-361	8	58
β-strand	366-372	7	52
α-helix	380	1
β-strand	381-386	6	52
β-strand	389-395	7	52
α-helix	397-422	26

Chain F: 22 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	16-26	11
α-helix	30-40	11
α-helix	55-70	16
α-helix	91-102	12
α-helix	122-149	28
α-helix	157-171	15
α-helix	178-180	3
α-helix	181-205	25
α-helix	209-231	23
α-helix	250-252	3
α-helix	253-272	20
α-helix	274-278	5
α-helix	283-289	7
α-helix	290-292	3
α-helix	297-308	12
β-strand	312-317	6	59
α-helix	337-340	4
α-helix	342-345	4
β-strand	348-352	5	59
α-helix	360-370	11
α-helix	372-375	4
β-strand	382-386	5	59
β-strand	391-396	6	59
β-strand	402-408	7	59
α-helix	417-430	14
α-helix	432-436	5
α-helix	437-439	3

Chain G: 5 helices, 30 β-strands

Element	Residues	Length	Sheet
β-strand	2-4	3	60
β-strand	9-13	5	61
β-strand	23-26	4	62
β-strand	35-40	6	62
β-strand	44-48	5	62
β-strand	57-60	4	62
β-strand	65-71	7	63
β-strand	80-85	6	63
β-strand	89-93	5	63
β-strand	115	1	62
β-strand	119-122	4	63
β-strand	127-133	7	64
β-strand	142-147	6	64
β-strand	151-159	9	64
β-strand	169-178	10	64
β-strand	186-190	5	65
β-strand	196-202	7	65
β-strand	206-210	5	65
α-helix	211	1
β-strand	240-244	5	65
β-strand	256-260	5	66
β-strand	275-280	6	66
β-strand	284-289	6	66
β-strand	296-302	7	66
β-strand	307-313	7	60
α-helix	320-321	2
β-strand	322-327	6	60
β-strand	331-335	5	60
β-strand	341-345	5	60
β-strand	350-359	10	61
β-strand	365-373	9	61
β-strand	377-381	5	61
α-helix	394-398	5
α-helix	402-410	9
α-helix	418-430	13

Chain H: 24 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	9-16	8	1
β-strand	20-27	8	1
α-helix	34-44	11
α-helix	48-50	3
β-strand	55-59	5	1
β-strand	62-66	5	1
β-strand	69-71	3	1
β-strand	81-90	10	1
α-helix	95-97	3
α-helix	98-116	19
α-helix	122-125	4
α-helix	128-142	15
β-strand	144-150	7	2
β-strand	153-158	6	2
α-helix	163-170	8
β-strand	174-177	4	3
α-helix	181-183	3
β-strand	184	1	4
α-helix	186-188	3
α-helix	191-196	6
α-helix	197-199	3
α-helix	206-212	7
α-helix	217-229	13
β-strand	233-236	4	3
α-helix	237-239	3
β-strand	244-247	4	5
α-helix	251-256	6
α-helix	258-268	11
β-strand	269	1	6
α-helix	270	1
α-helix	274-277	4
α-helix	278-287	10
β-strand	293	1	5
α-helix	294-300	7
α-helix	304-306	3
β-strand	308	1	6
α-helix	310-319	10
β-strand	323-326	4	5
β-strand	328-332	5	7
β-strand	346	1	7
α-helix	351-358	8
α-helix	362-369	8
β-strand	375-379	5	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
GATOR complex protein NPRL2	H	protein	401	Homo sapiens	Q8WTW4 (AlphaFold model)
GATOR1 complex protein DEPDC5	B	protein	1621	Homo sapiens	O75140 (AlphaFold model)
KICSTOR complex protein SZT2	D	protein	3451	Homo sapiens	Q5T011 (AlphaFold model)
KICSTOR complex protein kaptin	E	protein	457	Homo sapiens	Q9Y664 (AlphaFold model)
KICSTOR subunit 2	F	protein	466	Homo sapiens	Q96MD2
KICSTOR complex protein ITFG2	G	protein	466	Homo sapiens	Q969R8
GATOR complex protein NPRL3	C	protein	590	Homo sapiens	Q12980

Sequence of entity 1 (H), FASTA

>9O5A_1 GATOR complex protein NPRL2 (chains H)
MGYPYDVPDYADLNGGGGGSTMGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDT
VQVYIITKPELQNKLITVTAMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDAQAKTCALE
PIVKKLAGYLTTLELESSFVSMEESKQKLVPIMTILLEELNASGRCTLPIDESNTIHLKV
IEQRPDPPVAQEYDVPVFTKDKEDFFNSQWDLTTQQILPYIDGFRHIQKISAEADVELNL
VRIAIQNLLYYGVVTLVSILQYSNVYCPTPKVQDLVDDKSLQEACLSYVTKQGHKRASLR
DVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKLIQFGLMKNLIRRLQKYPVRVTREEQS
HPARLYTGCHSYDEICCKTGMSYHELDERLENDPNIIICWK

Sequence of entity 2 (B), FASTA

>9O5A_2 GATOR1 complex protein DEPDC5 (chains B)
MGDYKDDDDKGGGGGASTMRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIA
HPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVEL
TFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRV
VFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFS
RTFYDAKSVDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYP
VLVRLEQAEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGV
FEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHW
INHSFYTSKSQLFCNSFTPRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAY
DAQVFRLPGPSRAQCLTTCRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASD
DSSLGKSANILMIPHPHLHQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAES
MLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAE
LQGSGQRDPTHSSAELLELAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAG
MNPRTQNKDSLEDSVSTSPDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPD
RQGLQNDYTEGCYDLLPEADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKP
NPAVPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYE
SAQIHYTYSLCPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFW
RTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRS
DRMMRKGTAMKGLQMTGPISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVH
GGKSSAQSAESSSVAMTPTYMDSPRKDGAFFMEFVRSPRTASSAFYPQVSVDQTATPMLD
GTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSLTSSSTLTEILE
AMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITH
ASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAGVDDFASFQRKWFEVAFVAEE
LVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNN
RTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEG
PFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGF
VQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEE
RVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFWTSCLEKMHASA
P

Sequence of entity 3 (D), FASTA

>9O5A_3 KICSTOR complex protein SZT2 (chains D)
MEMDYKDDDDKGGGGGASTMASERPEPEVEEAGQVFLLMKKDYRISRNVRLAWFLSHLHQ
TVQATPQEMLLQSEQELEVLSVLPPGWQPDEPVVPRPFLLVPSTRVTFLAWQYRFVIELD
LSPSTGIVDDSTGEILFDEVFHALSRCLGGLLRPFRVPGSCIDFQPEIYVTIQAYSSIIG
LQSHQVLVQGCLLDPSQREVFLQQIYEQLCLFEDKVATMLQQQYDPQSQAEDQSPDSGDL
LGRKVGVSMVTADLGLVSMIRQGILALQLLPSNSSAGIIVITDGVTSVPDVAVCETLLNQ
LRSGTVACSFVQVGGVYSYDCSFGHVPNVELMKFIAMATFGSYLSTCPEPEPGNLGLTVY
HRAFLLYSFLRSGEALNPEYYCGSQHRLFNEHLVSASSNPALALRRKKHTEKEVPADLVS
TVSVRLREGYSVREVTLAKGGSQLEVKLVLLWKHNMRIEYVAMAPWPLEPEGPRVTRVEV
TMEGGYDILHDVSCALRQPIRSLYRTHVIRRFWNTLQSINQTDQMLAHLQSFSSVPEHFT
LPDSTKSGVPLFYIPPGSTTPVLSLQPSGSDSSHAQFAAYWKPVLSMDANSWQRWLHMHR
LVLILEHDTPIPKHLHTPGSNGRYSTIQCRISHSSLTSLLRDWSSFVLVEGYSYVKLLSS
APDQPPNSFYMVRIISKAPCMVLRLGFPIGTPAPARHKIVSGLREEILRLRFPHRVQSKE
PTPKVKRKGLGGAGGGSSPSKSPPVLGPQQALSDRPCLVVLHKPLDKLLIRYEKLPLDYR
APFLLTLEPPGPLPLVSGRSASSSLASLSRYLYHQRWLWSVPSGLAPALPLSAIAQLLSI
LTEVRLSEGFHFACSGEGIINMVLELPIQNEPPGQAAAEEKHTCVVQYILFPPHSTSTKD
SFSTDDDNDVEVEALEGDSELNLVTEVWVEPQYGRVGPGPGIWKHLQDLTYSEIPQALHP
RDAACIGSMLSFEYLIQLCQSKEWGPLPPEPRVSDGLDQGGDTCVHEIPFHFDLMGLLPQ
CQQLQMFFLLLAREPEGVPFAEGSCPANDMVLCLLHSCLGQELSDREIPLTPVDQAAFLS
EVLRRTCHVPGAEGPLLGVHGIPKEQAVGSTQATGDSAFTSLSVGLPETLKPLISAQPPQ
WRCYARLVNPQHVFLTFLPATFSDVQRLAACGLEGPPQEETKPKFGDWSGAPSLKDLGGT
GIKATKSHVPVLSVTLASDNAQNQGELSPPFRRDLQAYAGRQASQTESADGPRTRCPVYI
YSCSLEALREQMVGMQPPQAPRDLIFRTQFLDHPSPSSAWMEPRYKEAANHCALLQEHAQ
RCYVRGLFRSLQQAQSVTSQDLLTAVDACEELLQEIDITPFLLALCGHTWGLPHAPPSPG
PLSPGPFSSSMEEGAEPRERAILASESSIETEDLSEPEFQSTRVPGIPDPGPEISLTDVC
QLRGEAHGALHSVIQEKFLEISRLHFRTVPSNPHYFFYCPPSSRREDEGPRDTVDRKISD
LEFSEAELMGEEGDTSACCVVTESDPELEVEYRESRESDLGPAGLDSASLSDVDTVNPDE
DSFSILGGDSPTGPESFLHDLPPLFLHLTCSVRLRGQHSSVPVCSLPTCLGQVLSSLEGP
PVGGRVPLRDLSVTLDVFMLTLPLEVELPTASDPQHHRSTSESSASFPRSPGQPSSLRSD
DGLGPPLPPPEEERHPGLSNLATPHRLAIETTMNEIRWLLEDEMVGALRRGGIPQSPALH
RAAAHIHSSPGRSTCLRQTLPLSFVFGPERSLTQFKEEFRRLHLPGHVLLEDPDSGFFFV
AAGQQPGGSHGEPSSAAWAWHSHEDRAEGIEGETLTASPQAPGSPEDSEGVPLISLPRVP
QGGSQPGPSRGLSLMSSQGSVDSDHLGYDGGSSGSDSEGPNDTLGEKAPFTLRTPPGPAP
PQPSLSGLPGPCLPDFWLIVRVLQDRVEVYAHARSLIREDGGPGTECRHLQQLLVRRVGE
ICREVNQRLLLQDLHDSHVCNSLLVAESEEDLWRSETPFHSRQRAPLPSDDYAADESCAP
RGYLAATMQFVPGHFSCDVVWGTVIRVHSRLKMGPSMGVSRAIQALRSVLNAFSVVNRKN
MFVYQERATKAVYYLRLLETSCSDRPWKGDALPPSLALSRSQEPIYSEEASGPRSPLDMV
SSRSSDAARPVGQVDRHIQLLVHGVGQAGPEITDELVRVLCRRLDEATLDVITVMLVRNC
KLTPADVEFIQPPGSLPSEVLHLALPTSCRPWLPALAWYLRQNLLIFLHSPKYTDSNSRN
HFQHPLPPQGGLPDLDIYLYNKPGGQGTGGKGVACITLAFVDEGGAPLSLALWPPSSPGP
PDPLREEEFEQLTQVIRCPVVVDSSSAQNGAPRLRLDVWEKGNISIVQLEEKLRGAARQA
LADAIIELQLLPASLCTEDTPTGSLRNGSLETKSSAGRASTFPPAPVPGEPVTPPSKAGR
RSFWDMLSKTECGDLGSPKTTDDIVLDRPEDTRGRRRHKTESVRTPGGAERAPGSDSGAQ
RQKRRTTQLEEGEVGTLHPVFARVAQRWMEFMVQIGCASVSRSSAHMVSRFLLPSILSEF
TALVTSMAGDTSVRIFEQHLGSEPEIFGPCSPGQLGPSPRPAAERHLLLLGRNFLQWRRP
TQQAAKAMQRFEPGGDGSSGRNAPRQRLLLLEVVDKKLQLLTYNWAPDLGAALGRALVRL
VQWQNARAHLIFCLLSQKLGLFHHYGQLDFPVRDEKEPNPFLLPTMEVETLIRSASPPLS
REQGRLSGSSRGGGPLPLDTFPFDEALRDITAARPSSVLGPVPRPPDPVTYHGQQFLEIK
MAERRELERQMKMENLFVTWQQRSTPATMPISAGELETLKQSSRLVHYCATAMLFDPAAW
LHGPPETSGPPDGQRRHRPESGSGSREAPTSCESLDVSPPGAREEPWLKELSLAFLQQYV
QYLQSIGFVLVPLRPPSPARSTSRPRAMAILGTEGRGSFSCPKTKTDGSPKSTSSPVTTY
HLQRALPGGIILMELAFQGCYFCVKQFALECSRIPMGQAVNSQLSMLFTEECDKVRDLMH
VHSFSYDFHLRLVHQHVLGAHLVLRHGYHLTTFLRHFLAHHPDGPHFGRNHIYQGTLELP
TPLIAAHQLYNYVADHASSYHMKPLRMARPGGPEHNEYALVSAWHSSGSYLDSEGLRHQD
DFDVSLLVCHCAAPFEEQGEAERHVLRLQFFVVLTSQRELFPRLTADMRRFRKPPRLPPE
PEAPGSSAGSPGEASGLILAPGPAPLFPPLAAEVGMARARLAQLVRLAGGHCRRDTLWKR
LFLLEPPGPDRLRLGGRLALAELEELLEAVHAKSIGDIDPQLDCFLSMTVSWYQSLIKVL
LSRFPQSCRHFQSPDLGTQYLVVLNQKFTDCFVLVFLDSHLGKTSLTVVFREPFPVQPQD
SESPPAQLVSTYHHLESVINTACFTLWTRLL

Sequence of entity 4 (E), FASTA

>9O5A_4 KICSTOR complex protein kaptin (chains E)
MGYPYDVPDYADLNGGGGGSTMMGEAAVAAGPCPLREDSFTRFSSQSNVYGLAGGAGGRG
ELLAATLKGKVLGFRYQDLRQKIRPVAKELQFNYIPVDAEIVSIDTFNKSPPKRGLVVGI
TFIKDSGDKGSPFLNIYCDYEPGSEYNLDSIAQSCLNLELQFTPFQLCHAEVQVGDQLET
VFLLSGNDPAIHLYKENEGLHQFEEQPVENLFPELTNLTSSVLWLDVHNFPGTSRRLSAL
GCQSGYVRVAHVDQRSREVLQMWSVLQDGPISRVIVFSLSAAKETKDRPLQDEYSVLVAS
MLEPAVVYRDLLNRGLEDQLLLPGSDQFDSVLCSLVTDVDLDGRPEVLVATYGQELLCYK
YRGPESGLPEAQHGFHLLWQRSFSSPLLAMAHVDLTGDGLQELAVVSLKGVHILQHSLIQ
ASELVLTRLRHQVEQRRRRLQGLEDGAGAGPAENAAS

Sequence of entity 5 (F), FASTA

>9O5A_5 KICSTOR subunit 2 (chains F)
MGYPYDVPDYADLNGGGGGSTMGESIPLAAPVPVEQAVLETFFSHLGIFSYDKAKDNVEK
EREANKSAGGSWLSLLAALAHLAAAEKVYHSLTYLGQKLGGQSFFSRKDSIRTIYTSLHN
ELKKVVTGRGALGGTAPHVEELLSHLSEQLCFFVQARMEIADFYEKMYTLSTQKFINAEE
LVGLLDAIMKKYSSRFHHPILSPLESSFQLEVDVLCHLLKAQAQVSEWKFLPSLVNLHSA
HTKLQTWGQIFEKQRETKKHLFGGQSQKAVQPPHLFLWLMKLKNMLLAKFSFYFHEALSR
QTTASEMKTLTAKANPDFFGKISSFIRKYDAANVSLIFDNRGSESFQGHGYHHPHSYREA
PKGVDQYPAVVSLPSDRPVMHWPNVIMIMTDRTSDLNSLEKVVHFYDDKVQSTYFLTRPE
PHFTIVIIFESKKSERDSHFISFLNEVSLALKNPKVFASLKPGSKG

Sequence of entity 6 (G), FASTA

>9O5A_6 KICSTOR complex protein ITFG2 (chains G)
MEQKLISEEDLNGGGGGSTMRSVSYVQRVALEFSGSLFPHAICLGDVDNDTLNELVVGDT
SGKVSVYKNDDSRPWLTCSCQGMLTCVGVGDVCNKGKNLLVAVSAEGWFHLFDLTPAKVL
DASGHHETLIGEEQRPVFKQHIPANTKVMLISDIDGDGCRELVVGYTDRVVRAFRWEELG
EGPEHLTGQLVSLKKWMLEGQVDSLSVTLGPLGLPELMVSQPGCAYAILLCTWKKDTGSP
PASEGPTDGSRETPAARDVVLHQTSGRIHNKNVSTHLIGNIKQGHGTESSGSGLFALCTL
DGTLKLMEEMEEADKLLWSVQVDHQLFALEKLDVTGNGHEEVVACAWDGQTYIIDHNRTV
VRFQVDENIRAFCAGLYACKEGRNSPCLVYVTFNQKIYVYWEVQLERMESTNLVKLLETK
PEYHSLLQELGVDPDDLPVTRALLHQTLYHPDQPPQCAPSSLQDPT

Sequence of entity 7 (C), FASTA

>9O5A_7 GATOR complex protein NPRL3 (chains C)
MGYPYDVPDYADLNGGGGGSTMRDNTSPISVILVSSGSRGNKLLFRYPFQRSQEHPASQT
SKPRSRYAASNTGDHADEQDGDSRFSDVILATILATKSEMCGQKFELKIDNVRFVGHPTL
LQHALGQISKTDPSPKREAPTMILFNVVFALRANADPSVINCLHNLSRRIATVLQHEERR
CQYLTREAKLILALQDEVSAMADGNEGPQSPFHHILPKCKLARDLKEAYDSLCTSGVVRL
HINSWLEVSFCLPHKIHYAASSLIPPEAIERSLKAIRPYHALLLLSDEKSLLGELPIDCS
PALVRVIKTTSAVKNLQQLAQDADLALLQVFQLAAHLVYWGKAIIIYPLCENNVYMLSPN
ASVCLYSPLAEQFSHQFPSHDLPSVLAKFSLPVSLSEFRNPLAPAVQETQLIQMVVWMLQ
RRLLIQLHTYVCLMASPSEEEPRPREDDVPFTARVGGRSLSTPNALSFGSPTSSDDMTLT
SPSMDNSSAELLPSGDSPLNQRMTENLLASLSEHERAAILSVPAAQNPEDLRMFARLLHY
FRGRHHLEEIMYNENTRRSQLLMLFDKFRSVLVVTTHEDPVIAVFQALLP

Primary citation

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex. Lupton, C.J., Bayly-Jones, C., Dong, S. et al. Cell (2026). DOI 10.1016/j.cell.2025.12.005 · PubMed

Other PDB entries of the same protein (UniProt Q8WTW4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9V0J 2.97 Å, Cryo-EM structure of GATOR1-KICSTOR complex
8FW5 3.08 Å, Chimeric HsGATOR1-SpGtr-SpLam complex
9O5D 3.34 Å, The KICSTOR-GATOR1-SAMTOR complex
7T3B 3.9 Å, GATOR1-RAG-RAGULATOR - GAP Complex
6CES 4.0 Å, Cryo-EM structure of GATOR1-RAG
7T3A 4.0 Å, GATOR1-RAG-RAGULATOR - Inhibitory Complex
7T3C 4.0 Å, GATOR1-RAG-RAGULATOR - Dual Complex
6CET 4.4 Å, Cryo-EM structure of GATOR1
9O5E 5.0 Å, The dimeric KICSTOR-GATOR1 supercomplex

Browse structure collections

About this viewer

MolViewer shows 9O5A directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.