Structure of a constitutively open human TRPC3 mutant in the inhibited state. Determined by electron microscopy at 3.3 Å resolution. Released 25 Mar 2026.
Explore 9OLX in 3D Show helices and sheets RCSB PDB PDBe
9OLX contains 168 α-helices and 24 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 36-42 | 7 | |
| α-helix | 43-47 | 5 | |
| α-helix | 52-59 | 8 | |
| β-strand | 81 | 1 | 1 |
| β-strand | 84 | 1 | 1 |
| α-helix | 87-95 | 9 | |
| α-helix | 102-112 | 11 | |
| α-helix | 115-122 | 8 | |
| α-helix | 125-128 | 4 | |
| α-helix | 137-143 | 7 | |
| β-strand | 149 | 1 | 2 |
| β-strand | 155 | 1 | 2 |
| α-helix | 163-170 | 8 | |
| α-helix | 173-181 | 9 | |
| α-helix | 197-205 | 9 | |
| α-helix | 209-221 | 13 | |
| α-helix | 226-229 | 4 | |
| α-helix | 234-250 | 17 | |
| α-helix | 257-270 | 14 | |
| α-helix | 280-287 | 8 | |
| α-helix | 308-314 | 7 | |
| α-helix | 319-322 | 4 | |
| α-helix | 324-335 | 12 | |
| α-helix | 339-341 | 3 | |
| α-helix | 346-369 | 24 | |
| α-helix | 373-378 | 6 | |
| α-helix | 382-402 | 21 | |
| α-helix | 427-431 | 5 | |
| α-helix | 433-435 | 3 | |
| α-helix | 436-458 | 23 | |
| α-helix | 461-464 | 4 | |
| α-helix | 469-503 | 35 | |
| α-helix | 517-520 | 4 | |
| α-helix | 521-523 | 3 | |
| α-helix | 526-528 | 3 | |
| α-helix | 534-548 | 15 | |
| α-helix | 551-555 | 5 | |
| α-helix | 557-559 | 3 | |
| α-helix | 564-598 | 35 | |
| β-strand | 606 | 1 | 3 |
| α-helix | 614-622 | 9 | |
| α-helix | 631-633 | 3 | |
| β-strand | 636 | 1 | 3 |
| α-helix | 641-675 | 35 | |
| α-helix | 680-697 | 18 | |
| α-helix | 705-707 | 3 | |
| α-helix | 744-794 | 23 | |
| α-helix | 802-837 | 36 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Short transient receptor potential channel 3 | A, B, C, D | protein | 820 | Homo sapiens | Q13507 (AlphaFold model) |
>9OLX_1 Short transient receptor potential channel 3 (chains A, B, C, D) MEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLE ESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEA ILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLL MKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALE LSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVH RHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGL PFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVT DYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIF IAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEG LYAIAVVLSFSRIAYILPANESFGPLQISLGRAVKDIFKFMVLFIMVFFAFMIGMFILYS YYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVV VLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFI MRIVNFPKCRRRRLQKDIEMGMGNSKSRQIMKRLIKRYVLKAQVDKENDEVNEGELKEIK QDISSLRYELLEDKSQATEELAILIHKLSEISSLRYELLE
| ID | Name | Formula | Copies |
|---|---|---|---|
| A1CCX | (3,4-dihydroisoquinolin-2(1H)-yl)[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methano… | C20 H19 N3 O2 S | 4 |
Water and common crystallization additives (UNL) are not listed.
Functional and structural basis of a hypermorphic TRPC3 variant. Bell, B., Jaramillo-Granada, A.M., Romero, L.O. et al. Sci Adv (2026) 12:eaec9284-eaec9284. DOI 10.1126/sciadv.aec9284 · PubMed
Other PDB entries of the same protein (UniProt Q13507 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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