9RPV: ZAK-bound human disome
Structure of the ZAK-bound human disome. Determined by electron microscopy at 2.35 Å resolution. Released 10 Dec 2025.
- Method
- Electron microscopy
- Resolution
- 2.35 Å
- Organism
- Homo sapiens
- Chains
- 168
- Atoms
- 428,966
- Mol. weight
- 7974.13 kDa
- Ligands
- MG, ZN, ANM
- Released
- 10 Dec 2025
Explore 9RPV in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9RPV contains 1,138 α-helices and 1,091 β-strands across 154 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain E4: 9 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10 | 1 | |
| β-strand | 11 | 1 | 72 |
| α-helix | 12 | 1 | |
| α-helix | 25-31 | 7 | |
| α-helix | 58-63 | 6 | |
| α-helix | 72-74 | 3 | |
| α-helix | 75-86 | 12 | |
| α-helix | 92-98 | 7 | |
| α-helix | 103-111 | 9 | |
| α-helix | 118-128 | 11 | |
Chain La: 9 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-5 | 3 | |
| α-helix | 7-10 | 4 | |
| α-helix | 42-48 | 7 | |
| β-strand | 72-74 | 3 | 124 |
| α-helix | 75-77 | 3 | |
| α-helix | 79-81 | 3 | |
| α-helix | 84-92 | 9 | |
| β-strand | 98 | 1 | 285 |
| β-strand | 100-102 | 3 | 125 |
| α-helix | 103-106 | 4 | |
| β-strand | 110-112 | 3 | 124 |
| α-helix | 116-118 | 3 | |
| β-strand | 123-126 | 4 | 125 |
| β-strand | 128-129 | 2 | 124 |
| α-helix | 131-140 | 10 | |
| β-strand | 143-146 | 4 | 125 |
Chain LA: 13 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-5 | 3 | |
| α-helix | 10-12 | 3 | |
| α-helix | 14-16 | 3 | |
| β-strand | 18 | 1 | 137 |
| α-helix | 30-32 | 3 | |
| α-helix | 34-38 | 5 | |
| β-strand | 41-49 | 9 | 138 |
| β-strand | 58-64 | 7 | 138 |
| β-strand | 71-77 | 7 | 138 |
| α-helix | 78 | 1 | |
| β-strand | 79 | 1 | 139 |
| β-strand | 83 | 1 | 140 |
| β-strand | 87-90 | 4 | 138 |
| β-strand | 101-103 | 3 | 138 |
| α-helix | 104-106 | 3 | |
| α-helix | 108 | 1 | |
| β-strand | 112-113 | 2 | 141 |
| β-strand | 134-140 | 7 | 141 |
| α-helix | 142-144 | 3 | |
| β-strand | 145-149 | 5 | 141 |
| β-strand | 155-159 | 5 | 141 |
| β-strand | 163-165 | 3 | 138 |
| β-strand | 166 | 1 | 141 |
| β-strand | 169 | 1 | 139 |
| α-helix | 174-176 | 3 | |
| α-helix | 182-190 | 9 | |
| β-strand | 193 | 1 | 137 |
| α-helix | 201-203 | 3 | |
| β-strand | 224-225 | 2 | 142 |
| α-helix | 229-230 | 2 | |
| β-strand | 237-238 | 2 | 142 |
Chain Lb: 4 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-15 | 4 | |
| α-helix | 22-24 | 3 | |
| α-helix | 37-48 | 12 | |
| α-helix | 54-62 | 9 | |
Chain LB: 19 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-10 | 2 | |
| α-helix | 14-16 | 3 | |
| α-helix | 20-22 | 3 | |
| α-helix | 32-35 | 4 | |
| α-helix | 40-41 | 2 | |
| β-strand | 42 | 1 | 156 |
| β-strand | 45-60 | 16 | 157 |
| β-strand | 70-80 | 11 | 157 |
| β-strand | 84-95 | 12 | 158 |
| β-strand | 98-106 | 9 | 158 |
| α-helix | 112-115 | 4 | |
| α-helix | 116-118 | 3 | |
| α-helix | 131-134 | 4 | |
| α-helix | 135-137 | 3 | |
| α-helix | 140-156 | 17 | |
| β-strand | 159-165 | 7 | 158 |
| α-helix | 168-170 | 3 | |
| β-strand | 180-184 | 5 | 158 |
| β-strand | 186 | 1 | 156 |
| α-helix | 190-199 | 10 | |
| β-strand | 204-205 | 2 | 158 |
| α-helix | 207-209 | 3 | |
| β-strand | 216-222 | 7 | 157 |
| β-strand | 227-229 | 3 | 159 |
| α-helix | 231-234 | 4 | |
| α-helix | 237-241 | 5 | |
| β-strand | 270-272 | 3 | 159 |
| β-strand | 276-287 | 12 | 157 |
| α-helix | 300-302 | 3 | |
| β-strand | 320 | 1 | 160 |
| β-strand | 324 | 1 | 160 |
| β-strand | 330-333 | 4 | 157 |
| β-strand | 344-349 | 6 | 157 |
| α-helix | 361-363 | 3 | |
| β-strand | 365-368 | 4 | 157 |
| α-helix | 382-389 | 8 | |
| α-helix | 393-398 | 6 | |
Chain Lc: 4 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 15-21 | 7 | |
| β-strand | 27-29 | 3 | 161 |
| α-helix | 32-38 | 7 | |
| β-strand | 45-48 | 4 | 161 |
| α-helix | 54-66 | 13 | |
| β-strand | 70-73 | 4 | 161 |
| α-helix | 78-84 | 7 | |
| β-strand | 93-96 | 4 | 161 |
Chain LC: 25 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-11 | 5 | 178 |
| β-strand | 17-23 | 7 | 178 |
| α-helix | 24-25 | 2 | |
| α-helix | 26-29 | 4 | |
| α-helix | 34-45 | 12 | |
| α-helix | 46-48 | 3 | |
| α-helix | 49-51 | 3 | |
| β-strand | 64-66 | 3 | 179 |
| β-strand | 77-79 | 3 | 179 |
| β-strand | 90 | 1 | 179 |
| α-helix | 100-101 | 2 | |
| α-helix | 117-131 | 15 | |
| α-helix | 134-140 | 7 | |
| β-strand | 152-153 | 2 | 178 |
| α-helix | 156-160 | 5 | |
| α-helix | 164-173 | 10 | |
| α-helix | 178-185 | 8 | |
| β-strand | 188-189 | 2 | 180 |
| α-helix | 190 | 1 | |
| α-helix | 193-196 | 4 | |
| β-strand | 201-202 | 2 | 180 |
| β-strand | 208-211 | 4 | 178 |
| α-helix | 217-221 | 5 | |
| β-strand | 228-231 | 4 | 178 |
| β-strand | 234 | 1 | 178 |
| α-helix | 237-240 | 4 | |
| β-strand | 250-252 | 3 | 178 |
| α-helix | 254-258 | 5 | |
| α-helix | 260-263 | 4 | |
| α-helix | 279-282 | 4 | |
| α-helix | 290-293 | 4 | |
| α-helix | 296-300 | 5 | |
| α-helix | 302-305 | 4 | |
| α-helix | 311-313 | 3 | |
| α-helix | 316-317 | 2 | |
| α-helix | 322-328 | 7 | |
| α-helix | 332-362 | 31 | |
Chain Ld: 4 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 23 | 1 | 181 |
| β-strand | 26-27 | 2 | 182 |
| α-helix | 38-40 | 3 | |
| α-helix | 41-57 | 17 | |
| β-strand | 62-64 | 3 | 183 |
| α-helix | 66-72 | 7 | |
| β-strand | 84-85 | 2 | 182 |
| β-strand | 86-92 | 7 | 183 |
| β-strand | 102-108 | 7 | 183 |
| β-strand | 121 | 1 | 181 |
| α-helix | 122-123 | 2 | |
145 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| mRNA of the collided 80S | A4 | RNA | 14 | Homo sapiens | |
| mRNA of the stalled 80S | A5 | RNA | 8 | Homo sapiens | |
| P/E tRNA on the collided 80S | B4 | RNA | 150 | Homo sapiens | |
| P-site tRNA of the stalled 80S | B5 | RNA | 77 | Homo sapiens | |
| A/P tRNA on the collided 80S | D4 | RNA | 152 | Homo sapiens | |
| Endothelial differentiation-related factor 1 | E4 | protein | 148 | Homo sapiens | O60869 (AlphaFold model) |
| E-site tRNA of the stalled 80S | E5 | RNA | 75 | Homo sapiens | |
| 28S rRNA of the collided 80S | L5 | RNA | 5070 | Homo sapiens | |
| 5S rRNA | L7, M7 | RNA | 120 | Homo sapiens | |
| 5.8S rRNA of the collided 80S | L8 | RNA | 156 | Homo sapiens | |
| 60S ribosomal protein L8 | LA | protein | 257 | Homo sapiens | P62917 (AlphaFold model) |
| 60S ribosomal protein L3 | LB | protein | 403 | Homo sapiens | P39023 (AlphaFold model) |
89 more molecules are not listed.
Sequence of entity 1 (A4), FASTA
>9RPV_1 mRNA of the collided 80S (chains A4)
AUUUUAUGUUCUUU
Sequence of entity 2 (A5), FASTA
>9RPV_2 mRNA of the stalled 80S (chains A5)
AACGUAUG
Sequence of entity 3 (B4), FASTA
>9RPV_3 P/E tRNA on the collided 80S (chains B4)
AGCAGAGUGGCGCAGCGGAAGCGUGCUGGGCCCAUAACCCAGAGGUCGAUGGAUCGAAAC
CAUCCUCUGCUACCAAGCAGAGUGGCGCAGCGGAAGCGUGCUGGGCCCAUAACCCAGAGG
UCGAUGGAUCGAAACCAUCCUCUGCUACCA
Sequence of entity 4 (B5), FASTA
>9RPV_4 P-site tRNA of the stalled 80S (chains B5)
CGCGGGGUGGAGCAGCCCGGUAGCUCGUCGGGCUCAUAACCCGAAGGUCGUCGGUUCAAA
UCCGGCCCCCGCAACCA
Sequence of entity 5 (D4), FASTA
>9RPV_5 A/P tRNA on the collided 80S (chains D4)
GCCCGGAUAGCUCAGUCGGUAGAGCAGGGGAUUGAAAAUCCCCGUGUCCUUGGUUCGAUU
CCGAGUCCGGGCACCAGCCCGGAUAGCUCAGUCGGUAGAGCAGGGGAUUGAAAAUCCCCG
UGUCCUUGGUUCGAUUCCGAGUCCGGGCACCA
Sequence of entity 6 (E4), FASTA
>9RPV_6 Endothelial differentiation-related factor 1 (chains E4)
MAESDWDTVTVLRKKGPTAAQAKSKQAILAAQRRGEDVETSKKWAAGQNKQHSITKNTAK
LDRETEELHHDRVTLEVGKVIQQGRQSKGLTQKDLATKINEKPQVIADYESGRAIPNNQV
LGKIERAIGLKLRGKDIGKPIEKGPRAK
Sequence of entity 7 (E5), FASTA
>9RPV_7 E-site tRNA of the stalled 80S (chains E5)
UCCGAUAUAGCGUAACGGCUAUCACAUCACGCUUUCACCGUGGAGACCGGGGUUCGACUC
CCCGUAUCGGAGCCA
Sequence of entity 8 (L5), FASTA
>9RPV_8 28S rRNA of the collided 80S (chains L5)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAG
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGCGGCGGGGCGCGGGACAUGUGGCGUACGGAAGACCCGCUCCCCGGCGC
CGCUCGUGGGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCG
GUAGCGGCCCCCGGCGCGCCGGGCCCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCA
GCCCAAAGCGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAA
CAAGUACCGUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAA
CCGUUAAGAGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGC
GGGUCCGGCCGUGUCGGCGGCCCGGCGGAUCUUUCCCGCCCCCCGUUCCUCCCGACCCCU
CCACCCGCCCUCCCUUCCCCCGCCGCCCCUCCUCCUCCUCCCCGGAGGGGGCGGGCUCCG
GCGGGUGCGGGGGUGGGCGGGCGGGGCCGGGGGUGGGGUCGGCGGGGGACCGUCCCCCGA
CCGGCGACCGGCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGGCUCCG
GGACGGCUGGGAAGGCCCGGCGGGGAAGGUGGCUCGGGGGGCCCCGUCCGUCCGUCCGUC
CGUCCUCCUCCUCCCCCGUCUCCGCCCCCCGGCCCCGCGUCCUCCCUCGGGAGGGCGCGC
GGGUCGGGGCGGCGGCGGCGGCGGCGGUGGCGGCGGCGGCGGCGGCGGCGGGACCGAAAC
CCCCCCCGAGUGUUACAGCCCCCCCGGCAGCAGCACUCGCCGAAUCCCGGGGCCGAGGGA
GCGAGACCCGUCGCCGCGCUCUCCCCCCUCCCGGCGCCCACCCCCGCGGGGAAUCCCCCG
CGAGGGGGGUCUCCCCCGCGGGGGCGCGCCGGCGUCUCCUCGUGGGGGGGCCGGGCCACC
CCUCCCACGGCGCGACCGCUCUCCCACCCCUCCUCCCCGCGCCCCCGCCCCGGCGACGGG
GGGGGUGCCGCGCGCGGGUCGGGGGGCGGGGCGGACUGUCCCCAGUGCGCCCCGGGCGGG
UCGCGCCGUCGGGCCCGGGGGAGGUUCUCUCGGGGCCACGCGCGCGUCCCCCGAAGAGGG
GGACGGCGGAGCGAGCGCACGGGGUCGGCGGCGACGUCGGCUACCCACCCGACCCGUCUU
GAAACACGGACCAAGGAGUCUAACACGUGCGCGAGUCGGGGGCUCGCACGAAAGCCGCCG
UGGCGCAAUGAAGGUGAAGGCCGGCGCGCUCGCCGGCCGAGGUGGGAUCCCGAGGCCUCU
CCAGUCCGCCGAGGGCGCACCACCGGCCCGUCUCGCCCGCCGCGCCGGGGAGGUGGAGCA
CGAGCGCACGUGUUAGGACCCGAAAGAUGGUGAACUAUGCCUGGGCAGGGCGAAGCCAGA
GGAAACUCUGGUGGAGGUCCGUAGCGGUCCUGACGUGCAAAUCGGUCGUCCGACCUGGGU
AUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCCUCCGAAGUUUCCCUCAG
GAUAGCUGGCGCUCUCGCAGACCCGACGCACCCCCGCCACGCAGUUUUAUCCGGUAAAGC
GAAUGAUUAGAGGUCUUGGGGCCGAAACGAUCUCAACCUAUUCUCAAACUUUAAAUGGGU
AAGAAGCCCGGCUCGCUGGCGUGGAGCCGGGCGUGGAAUGCGAGUGCCUAGUGGGCCACU
UUUGGUAAGCAGAACUGGCGCUGCGGGAUGAACCGAACGCCGGGUUAAGGCGCCCGAUGC
CGACGCUCAUCAGACCCCAGAAAAGGUGUUGGUUGAUAUAGACAGCAGGACGGUGGCCAU
GGAAGUCGGAAUCCGCUAAGGAGUGUGUAACAACUCACCUGCCGAAUCAACUAGCCCUGA
AAAUGGAUGGCGCUGGAGCGUCGGGCCCAUACCCGGCCGUCGCCGGCAGUCGAGAGUGGA
CGGGAGCGGCGGCGGCGGCGCGCGCGCGCGCGCGUGUGGUGUGCGUCGGAGGGCGGCGGC
GGCGGCGGCGGCGGGGGUGUGGGGUCCUUCCCCCGCCCCCCCCCCCACGCCUCCUCCCCU
CCUCCCGCCCACGCCCCGCUCCCCGCCCCCGGAGCCCCGCGGACGCUACGCCGCGACGAG
UAGGAGGGCCGCUGCGGUGAGCCUUGAAGCCUAGGGCGCGGGCCCGGGUGGAGCCGCCGC
AGGUGCAGAUCUUGGUGGUAGUAGCAAAUAUUCAAACGAGAACUUUGAAGGCCGAAGUGG
AGAAGGGUUCCAUGUGAACAGCAGUUGAACAUGGGUCAGUCGGUCCUGAGAGAUGGGCGA
GCGCCGUUCCGAAGGGACGGGCGAUGGCCUCCGUUGCCCUCGGCCGAUCGAAAGGGAGUC
GGGUUCAGAUCCCCGAAUCCGGAGUGGCGGAGAUGGGCGCCGCGAGGCGUCCAGUGCGGU
AACGCGACCGAUCCCGGAGAAGCCGGCGGGAGCCCCGGGGAGAGUUCUCUUUUCUUUGUG
AAGGGCAGGGCGCCCUGGAAUGGGUUCGCCCCGAGAGAGGGGCCCGUGCCUUGGAAAGCG
UCGCGGUUCCGGCGGCGUCCGGUGAGCUCUCGCUGGCCCUUGAAAAUCCGGGGGAGAGGG
UGUAAAUCUCGCGCCGGGCCGUACCCAUAUCCGCAGCAGGUCUCCAAGGUGAACAGCCUC
UGGCAUGUUGGAACAAUGUAGGUAAGGGAAGUCGGCAAGCCGGAUCCGUAACUUCGGGAU
AAGGAUUGGCUCUAAGGGCUGGGUCGGUCGGGCUGGGGCGCGAAGCGGGGCUGGGCGCGC
GCCGCGGCUGGACGAGGCGCCGCCGCCCCCCCCACGCCCGGGGCACCCCCCUCGCGGCCC
UCCCCCGCCCCACCCCGCGCGCGCCGCUCGCUCCCUCCCCGCCCCGCGCCCUCUCUCUCU
CUCUCUCCCCCGCUCCCCGUCCUCCCCCCUCCCCGGGGGAGCGCCGCGUGGGGGCGGCGG
CGGGGGGAGAAGGGUCGGGGCGGCAGGGGCCGGCGGCGGCCCGCCGCGGGGCCCCGGCGG
CGGGGGCACGGUCCCCCGCGAGGGGGGCCCGGGCACCCGGGGGGCCGGCGGCGGCGGCGA
CUCUGGACGCGAGCCGGGCCCUUCCCGUGGAUCGCCCCAGCUGCGGCGGGCGUCGCGGCC
GCCCCCGGGGAGCCCGGCGGGCGCCGGCGCGCCCCCCCCCCCACCCCACGUCUCGUCGCG
CGCGCGUCCGCUGGGGGCGGGGAGCGGUCGGGCGGCGGCGGUCGGCGGGCGGCGGGGCGG
GGCGGUUCGUCCCCCCGCCCUACCCCCCCGGCCCCGUCCGCCCCCCGUUCCCCCCUCCUC
CUCGGCGCGCGGCGGCGGCGGCGGCAGGCGGCGGAGGGGCCGCGGGCCGGUCCCCCCCGC
CGGGUCCGCCCCCGGGGCCGCGGUUCCGCGCGGCGCCUCGCCUCGGCCGGCGCCUAGCAG
CCGACUUAGAACUGGUGCGGACCAGGGGAAUCCGACUGUUUAAUUAAAACAAAGCAUCGC
GAAGGCCCGCGGCGGGUGUUGACGCGAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAG
UGAAGAAAUUCAAUGAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAG
CCAAAUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUGAACGAGAUUCCCACUGU
CCCUACCUACUAUCCAGCGAAACCACAGCCAAGGGAACGGGCUUGGCGGAAUCAGCGGGG
AAAGAAGACCCUGUUGAGCUUGACUCUAGUCUGGCACGGUGAAGAGACAUGAGAGGUGUA
GAAUAAGUGGGAGGCCCCCGGCGCCCCCCCGGUGUCCCCGCGAGGGGCCCGGGGCGGGGU
CCGCCGGCCCUGCGGGCCGCCGGUGAAAUACCACUACUCUGAUCGUUUUUUCACUGACCC
GGUGAGGCGGGGGGGCGAGCCCCGAGGGGCUCUCGCUUCUGGCGCCAAGCGCCCGGCCGC
GCGCCGGCCGGGCGCGACCCGCUCCGGGGACAGUGCCAGGUGGGGAGUUUGACUGGGGCG
GUACACCUGUCAAACGGUAACGCAGGUGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCU
CCCGUGGAGCAGAAGGGCAAAAGCUCGCUUGAUCUUGAUUUUCAGUACGAAUACAGACCG
UGAAAGCGGGGCCUCACGAUCCUUCUGACCUUUUGGGUUUUAAGCAGGAGGUGUCAGAAA
AGUUACCACAGGGAUAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUG
AUCCUUCGAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGU
UCACCCACUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUAC
CCUACUGAUGAUGUGUUGUUGCCAUGGUAAUCCUGCUCAGUACGAGAGGAACCGCAGGUU
CAGACAUUUGGUGUAUGUGCUUGGCUGAGGAGCCAAUGGGGCGAAGCUACCAUCUGUGGG
AUUAUGACUGAACGCCUCUAAGUCAGAAUCCCGCCCAGGCGGAACGAUACGGCAGCGCCG
CGGAGCCUCGGUUGGCCUCGGAUAGCCGGUCCCCCGCCUGUCCCCGCCGGCGGGCCGCCC
CCCCCCUCCACGCGCCCCGCGCGCGCGGGAGGGCGCGUGCCCCGCCGCGCGCCGGGACCG
GGGUCCGGUGCGGAGUGCCCUUCGUCCUGGGAAACGGGGCGCGGCCGGAGAGGCGGCCGC
CCCCUCGCCCGUCACGCACCGCACGUUCGUGGGGAACCUGGCGCUAAACCAUUCGUAGAC
GACCUGCUUCUGGGUCGGGG
Sequence of entity 9 (L7, M7), FASTA
>9RPV_9 5S rRNA (chains L7, M7)
GUCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGG
GUCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU
Sequence of entity 10 (L8), FASTA
>9RPV_10 5.8S rRNA of the collided 80S (chains L8)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCU
Sequence of entity 11 (LA), FASTA
>9RPV_11 60S ribosomal protein L8 (chains LA)
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAK
VVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKP
GDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPIL
KAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAA
RRTGRLRGTKTVQEKEN
Sequence of entity 12 (LB), FASTA
>9RPV_12 60S ribosomal protein L3 (chains LB)
MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREV
DRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYK
NWHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHL
MEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKL
PRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIK
NNASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRAL
EKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 830 |
| ZN | Zinc ion | Zn | 7 |
| ANM | Anisomycin | C14 H19 N O4 | 1 |
Primary citation
ZAK activation at the collided ribosome. Huso, V.L., Niu, S., Catipovic, M.A. et al. Nature (2026) 649:1051-1060. DOI 10.1038/s41586-025-09772-8 · PubMed
Other PDB entries of the same protein (UniProt O60869 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 9P73 2.66 Å, In situ human eEF2-A/P-P/E state 80S ribosome
- 6ZVH 2.9 Å, EDF1-ribosome complex
- 9P8H 2.98 Å, In situ human A/P-P/E state 80S ribosome
- 9B0Q 3.2 Å, In situ human top-back di-ribosome structure (Composite map)
- 9B0S 3.8 Å, In situ human top-top di-ribosome structure (Composite map)
- 1X57 Solution structures of the HTH domain of human EDF-1 protein
Browse structure collections
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