9RTW: Mammalian AP3 complex on tubular membranes

Mammalian AP3 complex on tubular membranes (AP3 centered). Determined by electron microscopy at 7.4 Å resolution. Released 27 May 2026.

Method
Electron microscopy
Resolution
7.4 Å
Organisms
Pan troglodytes, Homo sapiens, Rattus norvegicus
Chains
8
Atoms
9,669
Mol. weight
274.44 kDa
Released
27 May 2026

Explore 9RTW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9RTW contains 148 α-helices and 72 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain B: 46 helices, 1 β-strand

ElementResiduesLengthSheet
α-helix44-529
α-helix56-7116
α-helix77-793
α-helix80-845
α-helix85-884
α-helix92-10514
α-helix110-12314
α-helix129-14113
α-helix145-1473
α-helix148-15912
α-helix164-18017
α-helix182-1843
α-helix185-19612
α-helix201-21414
α-helix220-2234
α-helix226-2327
α-helix233-2353
α-helix238-25518
α-helix295-30410
α-helix305-3095
β-strand31011
α-helix313-32614
α-helix329-3324
α-helix335-3428
α-helix347-36317
α-helix365-3673
α-helix369-3757
α-helix376-3783
α-helix383-39614
α-helix402-41211
α-helix418-43417
α-helix436-4383
α-helix439-44911
α-helix455-47016
α-helix477-48610
α-helix493-50513
α-helix513-52412
α-helix525-5273
α-helix530-54617
α-helix548-56316
α-helix568-58114
α-helix589-5924
α-helix594-5996
α-helix603-6064
α-helix612-6143
α-helix6181
α-helix622-6265
Chain D: 45 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix19-279
α-helix32-4716
α-helix52-6716
α-helix73-753
α-helix76-838
α-helix88-10114
α-helix107-1115
α-helix112-1209
α-helix125-13814
α-helix141-15414
α-helix160-17617
α-helix178-1803
α-helix181-19010
α-helix191-1933
α-helix197-21317
α-helix215-2217
α-helix222-23110
α-helix235-24814
α-helix249-2513
α-helix253-26917
α-helix273-28917
α-helix297-31317
α-helix317-33115
α-helix335-3395
α-helix342-3487
α-helix354-36714
α-helix373-38513
α-helix389-40921
α-helix415-42511
α-helix434-44714
α-helix449-4513
α-helix452-46413
α-helix466-4694
α-helix480-49112
α-helix493-4953
α-helix499-5068
α-helix509-5135
α-helix516-53924
α-helix543-55614
α-helix558-5614
α-helix566-58621
α-helix593-5986
α-helix612-6143
α-helix615-6184
α-helix629-6313
Chains E, F, G and H: 8 helices, 9 β-strands
ElementResiduesLengthSheet
β-strand16-2492
α-helix30-389
β-strand4313
β-strand51-5882
β-strand61-6882
α-helix75-817
β-strand87-9372
α-helix97-993
α-helix100-11112
α-helix114-1163
β-strand120-12672
α-helix136-1438
α-helix145-1473
β-strand153-15752
β-strand15914
β-strand16414
α-helix166-17712
Chain M: 17 helices, 28 β-strands
ElementResiduesLengthSheet
β-strand2-9812
β-strand14-19612
α-helix26-294
α-helix30-389
α-helix42-443
β-strand48-50312
β-strand55-61712
β-strand64-70712
α-helix76-9419
α-helix99-1046
α-helix106-11611
β-strand117-118213
β-strand121-122213
α-helix127-1337
β-strand134114
α-helix135-1373
α-helix139-14810
β-strand153114
α-helix159-1624
β-strand178-191141
β-strand197-211151
β-strand217-222615
α-helix225-2273
β-strand228-23361
β-strand237115
α-helix239-2457
β-strand248-250315
α-helix252-2532
β-strand255-264101
α-helix269-2713
β-strand274-282916
β-strand288-2971016
α-helix303-3042
β-strand305-31391
β-strand318-325816
β-strand329-33351
β-strand338-34471
β-strand347117
β-strand350117
β-strand353-360816
α-helix364-3674
α-helix370-3723
β-strand373-38081
β-strand389-395715
β-strand402-416151
Chain S: 8 helices, 7 β-strands
ElementResiduesLengthSheet
β-strand2-9818
β-strand14-19618
α-helix25-4016
β-strand49-51318
α-helix52-532
α-helix54-563
α-helix58-603
β-strand61-68818
β-strand71-78818
α-helix83-10119
α-helix106-1116
α-helix113-12311
β-strand124-125219
β-strand128-129219
α-helix134-15219

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
AP-3 complex subunit betaBprotein563Pan troglodytesA0A2I3SW12 (AlphaFold model)
AP-3 complex subunit delta-1Dprotein615Homo sapiensO14617 (AlphaFold model)
ADP-ribosylation factor 1E, F, G, Hprotein167Homo sapiensP84077 (AlphaFold model)
AP-3 complex subunit mu-1Mprotein418Rattus norvegicusA6KKR5 (AlphaFold model)
AP-3 complex subunit sigma-1Sprotein153Homo sapiensQ92572
Sequence of entity 1 (B), FASTA
>9RTW_1 AP-3 complex subunit beta (chains B)
KNEDLKQMLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYL
VRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEASADL
SPYVRKNAAHAIQKLYSLDPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLI
HKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWTMDPDHRLLIRNTKPLLQSRNA
AVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLK
SFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCAT
NILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVP
VARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKL
LTQYILNLGKYDQNYDIRDRTRFIRQLIVPNEKSGALSKYAKKIFLAQKPAPLLESPFKD
RDHFQLGTLSHTLNIKATGYLEL
Sequence of entity 2 (D), FASTA
>9RTW_2 AP-3 complex subunit delta-1 (chains D)
LQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAF
NIIEVMSASKFTFKRIGYLAASQSFHEGTNVIMLTTNQIRKDLSSPSQYDTGVALTGLSC
FVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDP
GVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGK
KLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQ
NLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIV
KKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLI
AAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQ
EPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRL
PQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPV
PEGLDLDAWINEPLS
Sequence of entity 3 (E, F, G, H), FASTA
>9RTW_3 ADP-ribosylation factor 1 (chains E, F, G, H)
KKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKI
RPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAM
NAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQK
Sequence of entity 4 (M), FASTA
>9RTW_4 AP-3 complex subunit mu-1 (chains M)
MIHSLFLINCSGDIFLEKHWKSVVSQSVCDYFFEAQEKAADVENVPPVISTPHHYLISIY
RDKLFFVSVIQTEVSPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNG
FPLATESNILKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAY
FDVVEEIDAIIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRLLDDVSFHPCIRFK
RWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHNISFKENSSCGRFDITIGPKQN
MGKTIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLAWDVGKITPQKLPSLKGLVNL
QSGAPKPEENPNLNIQFKIQQLAISGLKVNRLDMYGEKYKPFKGVKYITKAGKFQVRT
Sequence of entity 5 (S), FASTA
>9RTW_5 AP-3 complex subunit sigma-1 (chains S)
MIKAILIFNNYGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL
AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAG

Primary citation

Architecture of clathrin-independent AP3:ARF1-coated carriers. Kaufman, J.G.G., Tagiltsev, G., Stalder, D.S. et al. Sci Adv (2026) 12:eaed1529-eaed1529. DOI 10.1126/sciadv.aed1529 · PubMed

Other PDB entries of the same protein (UniProt A0A2I3SW12 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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