9RVT: ACE2 extracellular domain

ACE2 extracellular domain in complex with the macrocyclic peptide GR1.4. Determined by X-ray diffraction at 2.39 Å resolution. Released 8 Apr 2026.

Method

X-ray diffraction

Resolution

2.39 Å

Organisms

Homo sapiens, synthetic construct

Chains

8

Atoms

20,476

Mol. weight

288.3 kDa

Released

8 Apr 2026

Explore 9RVT in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9RVT contains 156 α-helices and 51 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 39 helices, 11 β-strands

Molecules and chains

>9RVT_1 Processed angiotensin-converting enzyme 2 (chains A, B, D, G)
GSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQS
TLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDN
PQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYE
DYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYIS
PIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVS
VGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMG
HIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEIN
FLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETY
CDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNM
LRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADSS
PHHHHHHHH

>9RVT_2 macrocyclic peptide GR1.4 (chains C, E, F, H)
ACEPLGYNLFLCSG

Primary citation

Yeast Display Technology Enables Rapid Discovery of Low-Nanomolar Macrocyclic Peptide Inhibitors of Human Angiotensin-Converting Enzyme 2. Romanyuk, Z., Bettin, G., Brear, P. et al. J Med Chem (2026) 69:7689-7708. DOI 10.1021/acs.jmedchem.5c02876 · PubMed

Related structures

Other PDB entries of the same protein (UniProt Q9BYF1 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 9SPA 1.79 Å, Apo ACE2 extracellular domain
• 28KD 2.02 Å, ACE2 extracellular domain in complex with the macrocyclic peptide GR3.1.2
• 8BYJ 2.07 Å, The structures of Ace2 in complex with bicyclic peptide inhibitor
• 8B9P 2.11 Å, ACE2 in complex with bicyclic peptide inhibitor
• 8XSF 2.16 Å, SARS-CoV-2 rbd + imcas-364 + hACE2
• 1R42 2.2 Å, Native Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2)
• 7JVO 2.2 Å, Importin alpha bound to the C-terminus of ACE2
• 8TOR 2.2 Å, ACE2-peptide 2 complex
• 9RVA 2.2 Å, Crystal structure of the extracellular part of human ACE2 in complex with the…
• 9UE7 2.27 Å, Cryo-EM structure of SARS-CoV-2 KP.2 spike in complex with ACE2
• 8TOQ 2.3 Å, ACE2-peptide 1 complex
• 8BFW 2.33 Å, The structures of Ace2 in complex with bicyclic peptide inhibitor

Browse structure collections

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