9SOL: TCR-581

Structure of TCR-581 in complex with Peptide-HLA. Determined by X-ray diffraction at 2.93 Å resolution. Released 16 Sept 2026.

Method: X-ray diffraction
Resolution: 2.93 Å
Organism: Homo sapiens
Chains: 20
Atoms: 26,430
Mol. weight: 382.22 kDa
Released: 16 Sept 2026

Explore 9SOL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9SOL contains 80 α-helices and 291 β-strands across 20 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	1
α-helix	20	1
β-strand	21-28	8	1
β-strand	31-37	7	1
β-strand	46-47	2	1
α-helix	50-52	3
α-helix	57-84	28
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-149	12
α-helix	152-161	10
α-helix	163-174	12
α-helix	176-179	4
β-strand	183	1	2
α-helix	184-185	2
β-strand	186-192	7	3
β-strand	198-208	11	3
β-strand	209	1	2
β-strand	214-219	6	4
β-strand	222-224	3	4
β-strand	228-230	3	3
α-helix	231-233	3
β-strand	234-235	2	3
β-strand	241-250	10	3
β-strand	257-262	6	4
β-strand	270-273	4	4

Chains B and Q: 1 helix, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
α-helix	4-5	2
β-strand	6-11	6	6
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	36-41	6	7
β-strand	44-46	3	7
β-strand	50-51	2	6
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Chains C, H, M and R: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	5	1	8

Chain D: 2 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	5-6	2	9
β-strand	12-15	4	10
β-strand	20-26	7	9
β-strand	33-39	7	10
β-strand	45-51	7	10
β-strand	55-59	5	9
β-strand	62-67	6	9
β-strand	72-77	6	9
α-helix	82-84	3
β-strand	86-93	8	10
β-strand	96	1	8
β-strand	99	1	8
β-strand	103-104	2	10
β-strand	108-113	6	10
β-strand	122-128	7	11
β-strand	135-140	6	11
β-strand	156-158	3	11
β-strand	162-166	5	11
β-strand	171-180	10	11
α-helix	187-190	4

Chain E: 6 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	5-7	3	12
β-strand	10-14	5	13
β-strand	19-24	6	12
β-strand	31-37	7	13
β-strand	44-50	7	13
β-strand	53-56	4	13
β-strand	65-68	4	12
β-strand	75-79	5	12
α-helix	84-86	3
β-strand	88-95	8	13
α-helix	100-101	2
β-strand	102-103	2	13
β-strand	107-112	6	13
α-helix	115-117	3
β-strand	119	1	14
β-strand	125-127	3	11
β-strand	138-148	11	11
β-strand	149	1	14
β-strand	153-159	7	15
β-strand	168-170	3	11
α-helix	174	1
β-strand	175-176	2	11
β-strand	186-195	10	11
α-helix	196-200	5
β-strand	205-212	8	15
β-strand	215	1	16
α-helix	226-227	2
β-strand	229	1	16
β-strand	231-238	8	15

Chains F and P: 10 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	17
α-helix	20	1
β-strand	21-28	8	17
β-strand	31-37	7	17
β-strand	46-47	2	17
α-helix	51-54	4
α-helix	57-84	28
β-strand	94-103	10	17
β-strand	109-118	10	17
β-strand	121-126	6	17
β-strand	133-135	3	17
α-helix	138-149	12
α-helix	152-161	10
α-helix	163-174	12
α-helix	176-179	4
β-strand	183	1	18
α-helix	184-185	2
β-strand	186-193	8	19
β-strand	198-208	11	19
β-strand	209	1	18
β-strand	214-219	6	20
β-strand	222-224	3	20
β-strand	228-230	3	19
α-helix	231-233	3
β-strand	234-235	2	19
β-strand	241-250	10	19
α-helix	254-256	3
β-strand	257-262	6	20
β-strand	270-273	4	20

Chain G: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	21
α-helix	4-5	2
β-strand	6-11	6	22
β-strand	21-30	10	22
β-strand	31	1	21
β-strand	36-41	6	23
β-strand	44-46	3	23
β-strand	50-51	2	22
α-helix	52-54	3
β-strand	55-56	2	22
β-strand	62-70	9	22
β-strand	78-83	6	23
β-strand	91-94	4	23

Chains I and S: 1 helix, 18 β-strands

Element	Residues	Length	Sheet
β-strand	5-6	2	25
β-strand	12-15	4	26
β-strand	20-26	7	25
β-strand	33-39	7	26
β-strand	46-51	6	26
β-strand	55-59	5	25
β-strand	62-67	6	25
β-strand	72-77	6	25
α-helix	82-84	3
β-strand	86-93	8	26
β-strand	96	1	24
β-strand	99	1	24
β-strand	103-104	2	26
β-strand	108-113	6	26
β-strand	122-128	7	27
β-strand	135-140	6	27
β-strand	156-158	3	27
β-strand	162-166	5	27
β-strand	171-180	10	27

6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MHC class I antigen	A, F, K, P	protein	276	Homo sapiens	A0A5B8RNS7 (AlphaFold model)
Beta-2-microglobulin	B, G, L, Q	protein	100	Homo sapiens	P61769 (AlphaFold model)
Piwi-like protein 1	C, H, M, R	protein	9	Homo sapiens	Q96J94 (AlphaFold model)
TCR alpha	D, I, N, S	protein	208	Homo sapiens
TCR beta	E, J, O, T	protein	242	Homo sapiens

Sequence of entity 1 (A, F, K, P), FASTA

>9SOL_1 MHC class I antigen (chains A, F, K, P)
GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYW
DGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDG
KDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQ
RTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEP

Sequence of entity 2 (B, G, L, Q), FASTA

>9SOL_2 Beta-2-microglobulin (chains B, G, L, Q)
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD
WSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (C, H, M, R), FASTA

>9SOL_3 Piwi-like protein 1 (chains C, H, M, R)
SLSNRLYYL

Sequence of entity 4 (D, I, N, S), FASTA

>9SOL_4 TCR alpha (chains D, I, N, S)
MAKEVEQNSGPLSVPEGAIASLNCTYSDRGSQSFFWYRQYSGKSPELIMSIYSNGDKEDG
RFTAQLNKASQYVSLLIRDSQPSDSATYLCAVNDSNFGNEKLTFGTGTRLTIIPNIQNPD
PAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWS
NKSDFACANAFNNSIIPEDTFFPSPESS

Sequence of entity 5 (E, J, O, T), FASTA

>9SOL_5 TCR beta (chains E, J, O, T)
NAGVMQNPRHLVRRRGQEARLRCSPMKGHSHVYWYRQLPEEGLKFMVYLQKENIIDESGM
PKERFSAEFPKEGPSILRIQQVVRGDSAAYFCASSAGTTEQYFGPGTRLTVTEDLNKVFP
PEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPA
LNDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGR
AD

Primary citation

Isolation of Human TCRs specific to any peptide-HLA complex. Karuppiah, V., Rangel, V.L. Nat Commun (2026).

Other PDB entries of the same protein (UniProt A0A5B8RNS7 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9GV7 1.86 Å, Structure of reverse docking TCR in complex with peptide-HLA
6TMO 2.1 Å, Structure determination of an enhanced affinity TCR, a24b17, in complex with HLA-A*02:01…
9DL1 2.3 Å, Crystal Structure of HLA-A*02:01/NY-ESO-1 (SLLMWITQV) and a target specific TRACeR-I
9SOK 2.5 Å, Structure of three-domain single chain TCR-581 in complex with Peptide-HLA
9GV6 2.77 Å, Structure of TCR in complex with peptide-HLA

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