9TF0: Echovirus 18

Name: PDB 9TF0: Structure of echovirus 18 in complex with neonatal Fc receptor
Published: 2026-06-24
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: virus

Structure of echovirus 18 in complex with neonatal Fc receptor. Determined by electron microscopy at 2.26 Å resolution. Released 24 Jun 2026.

Method: Electron microscopy
Resolution: 2.26 Å
Organisms: Echovirus E18, Homo sapiens
Chains: 6
Atoms: 7,607
Mol. weight: 136.58 kDa
Ligands: PLM
Released: 24 Jun 2026

Explore 9TF0 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9TF0 contains 38 α-helices and 74 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 20 β-strands

Element	Residues	Length	Sheet
α-helix	8-10	3
β-strand	11	1	9
β-strand	14	1	10
β-strand	25-26	2	3
α-helix	28-30	3
α-helix	38-41	4
β-strand	44	1	10
β-strand	47	1	9
α-helix	54-56	3
β-strand	57	1	2
α-helix	58-61	4
β-strand	66-74	9	1
α-helix	82-84	3
β-strand	85-87	3	11
α-helix	96-103	8
β-strand	105-122	18	1
β-strand	136-142	7	11
β-strand	164-168	5	11
α-helix	172-174	3
β-strand	175-178	4	1
β-strand	187-188	2	1
β-strand	193	1	12
β-strand	194-196	3	13
β-strand	200-203	4	13
α-helix	205-208	4
β-strand	213-218	6	11
β-strand	227-245	19	1
α-helix	247-248	2
β-strand	249	1	14
α-helix	252-253	2
β-strand	270	1	4

Chain B: 11 helices, 22 β-strands

Element	Residues	Length	Sheet
β-strand	14-17	4	15
β-strand	22-25	4	15
β-strand	28-33	6	8
α-helix	34-36	3
α-helix	41-43	3
α-helix	52-53	2
β-strand	54	1	8
α-helix	57-60	4
β-strand	64-65	2	8
β-strand	69-70	2	16
α-helix	71-72	2
β-strand	78-82	5	17
α-helix	84-86	3
α-helix	90-98	9
β-strand	99-111	13	8
β-strand	119-128	10	17
β-strand	134	1	18
α-helix	143-145	3
α-helix	151-152	2
β-strand	153-154	2	17
β-strand	156	1	19
β-strand	165	1	18
β-strand	168	1	19
β-strand	176	1	14
α-helix	178-183	6
β-strand	186-190	5	17
β-strand	196-201	6	8
β-strand	210	1	8
β-strand	215	1	12
β-strand	218-229	12	17
β-strand	239-240	2	16
β-strand	241-254	14	8
α-helix	257-258	2

Chain C: 7 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	23	1	1
α-helix	30-33	4
β-strand	39-40	2	1
β-strand	42	1	2
α-helix	43-47	5
β-strand	51-53	3	3
β-strand	58	1	4
α-helix	65-67	3
β-strand	69-73	5	3
β-strand	84-87	4	5
α-helix	100-105	6
β-strand	108	1	6
β-strand	110-112	3	7
β-strand	115-121	7	3
β-strand	128-136	9	5
α-helix	146-151	6
β-strand	153-158	6	5
α-helix	159	1
β-strand	164-169	6	3
β-strand	178-179	2	7
α-helix	184-186	3
β-strand	190-200	11	5
β-strand	208-217	10	3
β-strand	222-223	2	7
β-strand	226	1	6

Chain D: 3 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	36-38	3
α-helix	51-54	4
β-strand	57	1	8
α-helix	60-62	3

Chain G: 6 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	7-14	8	20
β-strand	24-30	7	20
β-strand	33-39	7	20
α-helix	69-78	10
α-helix	79-81	3
β-strand	89-97	9	20
β-strand	105-112	8	20
β-strand	115-120	6	20
β-strand	127-129	3	20
α-helix	132-142	11
α-helix	145-153	9
α-helix	154-158	5
α-helix	159-169	11

Chain H: 0 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	21
β-strand	6	1	22
β-strand	28-30	3	22
β-strand	31	1	21
β-strand	55-56	2	22
β-strand	62-63	2	22

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Echovirus 18 viral protein 3	C	protein	239	Echovirus E18	Q8V635 (AlphaFold model)
Echovirus 18 viral protein 4	D	protein	68	Echovirus E18	Q8V635 (AlphaFold model)
Echovirus 18 viral protein 1	A	protein	287	Echovirus E18	Q8V635 (AlphaFold model)
Echovirus 18 viral protein 2	B	protein	260	Echovirus E18	Q8V635 (AlphaFold model)
IgG receptor FcRn large subunit p51	G	protein	267	Homo sapiens	P55899 (AlphaFold model)
Beta-2-microglobulin	H	protein	99	Homo sapiens	P61769 (AlphaFold model)

Sequence of entity 1 (C), FASTA

>9TF0_1 Echovirus 18 viral protein 3 (chains C)
GVPVLNTPGSNQFLTSDDYQSPSAMPQFDETPEMHIPGEVRNLMEIAEVDSVVPVNNVTG
KTKSMDAYQIPVGTGNTDKTKPIFSFQMDPGYSSVLKRTLLGEMLNYYAHWSGSVKLTFL
FCGSAMATGKLLISYSPPGASVPTSRKDAMLGTHIVWDIGLQSSCVLCVPWISQSHYRMV
QQDPYTSAGYITCWYQTNIVVPPGAPTSCDVLCFASACNDFSVRLLRDTPFMAQPGKLQ

Sequence of entity 2 (D), FASTA

>9TF0_2 Echovirus 18 viral protein 4 (chains D)
GAQVSTQKTGAHETSLSAKGNSIIHYTNINFYKDAASSASNRQDIQQDPGKFTDPVKDLM
IKTLPALN

Sequence of entity 3 (A), FASTA

>9TF0_3 Echovirus 18 viral protein 1 (chains A)
GDNQDRTVANTQPSGPSNSTEIPALTAVETGHTSQVDPSDTIQTRHVVNFHSRSESTIEN
FMGRAACVFMDQYKINGEETSTDRFAVWTINIREMAQLRRKCEMFTYMRFDIEMTMVITS
CQDQGTILDQDMPVLTHQIMYVPPGGPIPAKVDGYEWQTSTNPSVFWTEGNAPPRISIPF
ISVGNAYSSFYDGWSHFTQDGTYGYTTLNAMGKLYIRHVNRSSPHQITSTIRVYFKPKHI
KAWVPRPPRLCPYINKRDVNFVVTEITDSRTSITDTPHPEHSVLATH

Sequence of entity 4 (B), FASTA

>9TF0_4 Echovirus 18 viral protein 2 (chains B)
SPSAEECGYSDRVRSMTLGNSTITTQESANVVVGYGEWPSYLSDREATAEDQPTQPDVAT
CRFYTLESVQWEKTSPGWWWKFPEALKNMGLFGQNMHYHYLGRAGYTIHVQCNASKFHQG
CLLVVCVPEAEMGCADTDTTFPATELTTEDTPHVFTSDSITGKKVQAAVCNAGMGVGVGN
LTIFPHQWINLRTNNSATIVIPYINSVPMDNMFRHYNFTLMIIPFAPLNFTDGATAYVPI
TVTIAPMYAEYNGLRLASTQ

Sequence of entity 5 (G), FASTA

>9TF0_5 IgG receptor FcRn large subunit p51 (chains G)
AESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWY
WEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNF
DLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPP
SMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSL
TVKSGDEHHYCCIVQHAGLAQPLRVEL

Sequence of entity 6 (H), FASTA

>9TF0_6 Beta-2-microglobulin (chains H)
IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDW
SFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Ligands and cofactors

ID	Name	Formula	Copies
PLM	Palmitic acid	C16 H32 O2	1

Primary citation

Particles of echovirus 18 open to release their genomes in vivo. Mukhamedova, L., Buchta, D., Trebichalska, Z. et al. Proc Natl Acad Sci U S A (2026) 123:e2601182123-e2601182123. DOI 10.1073/pnas.2601182123 · PubMed

Other PDB entries of the same protein (UniProt Q8V635 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9TF1 2.44 Å, Structure of echovirus 18, activated particle
9TF2 2.86 Å, Structure of echovirus 18, empty particle
7B5F 2.9 Å, Structure of echovirus 18 in complex with neonatal Fc receptor
6HBG 3.16 Å, Echovirus 18 native particle
6HBJ 3.16 Å, Echovirus 18 empty particle
6HBH 3.36 Å, Echovirus 18 A-particle
6HBL 3.7 Å, Echovirus 18 Open particle without three pentamers
6HBK 3.8 Å, Echovirus 18 Open particle without one pentamer
6HHT 4.05 Å, Echovirus 18 Open particle without two pentamers
9S63 4.3 Å, Echovirus 18 in situ, virion, I4
9SPU 6.5 Å, Echovirus 18 particle missing one pentamer in situ, symmetrized reconstruction (C5)

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