9UC1: Ion transport protein

Crystal structure of voltage-gated sodium channel NavAb N49K/S178T mutant. Determined by X-ray diffraction at 2.5 Å resolution. Released 18 Feb 2026.

Method: X-ray diffraction
Resolution: 2.5 Å
Organism: Aliarcobacter butzleri
Chains: 1
Atoms: 2,345
Mol. weight: 38.11 kDa
Ligands: CA, 1N7, LMT, PX4
Released: 18 Feb 2026

Explore 9UC1 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9UC1 contains 16 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 16 helices, 0 β-strands

Element	Residues	Length
α-helix	1000-1009	10
α-helix	1012-1032	21
α-helix	1035-1065	31
α-helix	1068-1072	5
α-helix	1075-1086	12
α-helix	1097-1101	5
α-helix	1102-1107	6
α-helix	1108-1112	5
α-helix	1114-1125	12
α-helix	1128-1130	3
α-helix	1131-1152	22
α-helix	1157-1160	4
α-helix	1163-1174	12
α-helix	1179-1184	6
α-helix	1185-1188	4
α-helix	1194-1224	31

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ion transport protein	A	protein	271	Aliarcobacter butzleri	A8EVM5 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>9UC1_1 Ion transport protein (chains A)
GSGSMYLRITNIVESSFFTKFIIYLIVLNGITMGLETSKTFMQSFGVYTTLFKQIVITIF
TIEIILRIYVHRISFFKDPWSLFDFFVVAISLVPTSSGFEILRVLRVLRLFRLVTAVPQM
RKIVSALISVIPGMLSVIALMTLFFYIFAIMATQLFGERFPEWFGTLGESFYTLFQVMTL
ETWSMGIVRPLMEVYPYAWVFFIPFIFVVTFVMINLVVAIIVDAMAILNQKEEQHIIDEV
QSHEDNINNEIIKLREEIVELKELIKTSLKN

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	3
1N7	Chapso	C32 H59 N2 O8 S	1
LMT	Dodecyl-beta-D-maltoside	C24 H46 O11	1
PX4	1,2-dimyristoyl-sn-glycero-3-phosphocholine	C36 H73 N O8 P	8

Primary citation

Structure-function analysis of the lithium-ion selectivity of the voltage-gated sodium channel. Maeda, Y.K., Kojima, K., Nakamura, T.Y. et al. J Gen Physiol (2026) 158. DOI 10.1085/jgp.202513855 · PubMed

Other PDB entries of the same protein (UniProt A8EVM5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6MWD 2.33 Å, NavAb Voltage-gated Sodium Channel, residues 1-239 with mutation T206S
6MWA 2.4 Å, NavAb Voltage-gated Sodium Channel, residues 1-239
6MWG 2.5 Å, NavAb Voltage-gated Sodium Channel, residues 1-239, with mutation T206V
6C1M 2.52 Å, NavAb NormoPP mutant
8DIV 2.54 Å, Crystal structure of NavAb I22V as a basis for the human Nav1.7 Inherited…
6MWB 2.6 Å, NavAb Voltage-gated Sodium Channel, residues 1-239 with mutation T206A
8VGL 2.6 Å, CryoEM structure of Nav1.7 in complex with wild type Fab 7A9
8VGM 2.6 Å, CryoEM structure of Nav1.7 in complex with engineered conformationally rigid Fab 7A9.4DS
3RVY 2.7 Å, Crystal structure of the NavAb voltage-gated sodium channel (Ile217Cys, 2.7 A)
5KLB 2.7 Å, Crystal structure of the CavAb voltage-gated calcium channel(wild-type, 2.7A)
6C1K 2.7 Å, HypoPP mutant with ligand1
8DJ0 2.7 Å, Crystal structure of NavAb L123T as a basis for the human Nav1.7 Inherited…

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