9VZS: Peroxisome proliferator-activated receptor alpha

X-ray structure of human PPARalpha ligand binding domain-10-hydroxystearic acid (10-HSA) co-crystals obtained by cross-seeding. Determined by X-ray diffraction at 1.46 Å resolution. Released 27 May 2026.

Method: X-ray diffraction
Resolution: 1.46 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,380
Mol. weight: 31.25 kDa
Ligands: WAD
Released: 27 May 2026

Explore 9VZS in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9VZS contains 19 α-helices and 4 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 19 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	201-217	17
α-helix	222-230	9
α-helix	238	1
β-strand	239-241	3	1
α-helix	244-254	11
α-helix	256-259	4
α-helix	262-264	3
α-helix	266-267	2
α-helix	268-291	24
α-helix	302-321	20
α-helix	322-324	3
β-strand	325-326	2	1
β-strand	329-332	4	1
β-strand	337-340	4	1
α-helix	341-346	6
α-helix	348	1
α-helix	351-353	3
α-helix	356-366	11
α-helix	372-383	12
α-helix	394-415	22
α-helix	422-450	29
α-helix	455-457	3
α-helix	458-464	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Peroxisome proliferator-activated receptor alpha	A	protein	273	Homo sapiens	Q07869 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>9VZS_1 Peroxisome proliferator-activated receptor alpha (chains A)
GSHMTADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLV
AKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYE
AIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDI
SLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQ
LVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY

Ligands and cofactors

ID	Name	Formula	Copies
WAD	(10R)-10-hydroxyoctadecanoic acid	C18 H36 O3	1

Water and common crystallization additives (GOL) are not listed.

Primary citation

Microbial 10-oxostearic acid protects mice against colitis via the nuclear receptor PPAR alpha. Liu, J., Li, H., Tian, Y. et al. Nat Microbiol (2026) 11:2232-2246. DOI 10.1038/s41564-026-02321-7 · PubMed

Other PDB entries of the same protein (UniProt Q07869 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6KAX 1.23 Å, X-ray structure of human PPARalpha ligand binding domain-intrinsic fatty acid (E. coli…
6LXA 1.23 Å, X-ray structure of human PPARalpha ligand binding domain-eicosapentaenoic acid (EPA)…
6KB1 1.25 Å, X-ray structure of human PPARalpha ligand binding domain-tetradecylthioacetic acid (TTA)…
6LX6 1.3 Å, X-ray structure of human PPARalpha ligand binding domain-palmitic acid co-crystals…
6KB0 1.35 Å, X-ray structure of human PPARalpha ligand binding domain-5,8,11,14-eicosatetraynoic acid…
9IWM 1.39 Å, X-ray structure of human PPARalpha ligand binding domain-GW7647-TRAP220 coactivator…
6LX9 1.4 Å, X-ray structure of human PPARalpha ligand binding domain-arachidonic acid co-crystals…
6LX7 1.41 Å, X-ray structure of human PPARalpha ligand binding domain-stearic acid co-crystals…
6KB4 1.42 Å, X-ray structure of human PPARalpha ligand binding domain-pemafibrate co-crystals…
6KB6 1.43 Å, X-ray structure of human PPARalpha ligand binding domain-tetradecylthioacetic acid (TTA)…
6KB3 1.45 Å, X-ray structure of human PPARalpha ligand binding domain-GW7647 co-crystals obtained by…
6KB8 1.47 Å, X-ray structure of human PPARalpha ligand binding domain-GW7647 co-crystals obtained by…

Browse structure collections

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