9W6A: 18-3 TCR

Crystal structure of 18-3 TCR in complex with HLA-A*11:01 bound to HPV16-E6(93-101). Determined by X-ray diffraction at 2.35 Å resolution. Released 5 Aug 2026.

Method: X-ray diffraction
Resolution: 2.35 Å
Organisms: Homo sapiens, Human papillomavirus 16, Mus musculus
Chains: 5
Atoms: 6,792
Mol. weight: 94.17 kDa
Released: 5 Aug 2026

Explore 9W6A in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9W6A contains 22 α-helices and 72 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	8
β-strand	10-14	5	9
β-strand	19-25	7	8
β-strand	32-38	7	9
β-strand	44-51	8	9
β-strand	56-58	3	8
β-strand	62-67	6	8
β-strand	72-77	6	8
α-helix	82-84	3
β-strand	86-93	8	9
β-strand	100-102	3	9
β-strand	106-111	6	9
β-strand	120-126	7	10
β-strand	133-138	6	10
β-strand	149-151	3	10
β-strand	154-156	3	10
α-helix	157-159	3
β-strand	160-164	5	10
β-strand	169-178	10	10
α-helix	185-187	3
α-helix	191-193	3
β-strand	199	1	10

Chain B: 4 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	11
β-strand	10-14	5	12
β-strand	19-25	7	11
β-strand	31-38	8	12
β-strand	42-51	10	12
β-strand	54-57	4	12
β-strand	65-67	3	11
β-strand	73-78	6	11
α-helix	83-85	3
β-strand	87-94	8	12
β-strand	105-106	2	12
β-strand	110-115	6	12
β-strand	122	1	13
β-strand	125-130	6	10
α-helix	131-132	2
α-helix	133-139	7
β-strand	141-151	11	10
β-strand	152	1	13
β-strand	156-162	7	14
β-strand	165-167	3	14
β-strand	171-173	3	10
β-strand	178-179	2	10
β-strand	189-198	10	10
α-helix	199-203	5
β-strand	208-215	8	14
β-strand	218	1	15
β-strand	232	1	15
β-strand	234-241	8	14

Chain C: 12 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	1
α-helix	20	1
β-strand	21-28	8	1
β-strand	31-37	7	1
β-strand	46-47	2	1
α-helix	50-52	3
α-helix	57-85	29
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-149	12
α-helix	152-158	7
α-helix	159-163	5
α-helix	164-174	11
α-helix	176-179	4
β-strand	183	1	2
α-helix	184-185	2
β-strand	186-193	8	3
β-strand	198-208	11	3
β-strand	209	1	2
β-strand	214-219	6	4
β-strand	222-223	2	4
α-helix	225-227	3
β-strand	229-230	2	3
α-helix	231-233	3
β-strand	234-235	2	3
β-strand	241-250	10	3
α-helix	254-256	3
β-strand	257-262	6	4
β-strand	270-273	4	4

Chain D: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
α-helix	4-5	2
β-strand	6-11	6	6
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	35-41	7	7
β-strand	44-45	2	7
α-helix	46	1
β-strand	50-51	2	6
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-84	7	7
β-strand	91-94	4	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MHC class I antigen	C	protein	275	Homo sapiens	A0A6M6CC39 (AlphaFold model)
Beta-2-microglobulin	D	protein	99	Homo sapiens	P61769 (AlphaFold model)
Protein E6	E	protein	9	Human papillomavirus 16	P03126 (AlphaFold model)
18-3 TCR alpha chain	A	protein	201	Mus musculus
18-3 TCR beta chain	B	protein	242	Mus musculus

Sequence of entity 1 (C), FASTA

>9W6A_1 MHC class I antigen (chains C)
GSHSMRYFYTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYW
DQETRNVKAQSQTDRVDLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDG
KDYIALNEDLRSWTAADMAAQITKRKWEAAHAAEQQRAYLEGRCVEWLRRYLENGKETLQ
RTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWE

Sequence of entity 2 (D), FASTA

>9W6A_2 Beta-2-microglobulin (chains D)
IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDW
SFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (E), FASTA

>9W6A_3 Protein E6 (chains E)
TTLEQQYNK

Sequence of entity 4 (A), FASTA

>9W6A_4 18-3 TCR alpha chain (chains A)
EQVEQRPPHLSVREGDSAVIICTYTDPNSYYFFWYKQEPGAGLQLLMKVFSSTEINEGQG
FTVLLNKKDKQLSLNLTAAHPGDSAVYFCAVSAPNYNVLYFGSGTKLTVEPNIQNPDPAV
YQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSNKS
DFACANAFNNSIIPEDTFFPS

Sequence of entity 5 (B), FASTA

>9W6A_5 18-3 TCR beta chain (chains B)
AVTQSPRSKVAVTGGKVTLSCHQTNNHDYMYWYRQDTGHGLRLIHYSYVADSTEKGDIPD
GYKASRPSQENFSLILELASLSQTAVYFCASSPGTGVNTGQLYFGEGSKLTVLEDLKNVF
PPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQP
ALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWG
RA

Primary citation

Harnessing CD8 co-receptor dependency of HPV-E6 specific TCR for tumor immunotherapy. Wang, J., Tan, S.G., Chai, Y. et al. To be published.

Other PDB entries of the same protein (UniProt A0A6M6CC39 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7WKJ 1.5 Å, A COVID-19 T-cell response detection method based on a newly identified human CD8+ T…
9IKY 3.45 Å, Crystal structure of 1-2C-T96F TCR in complex with HLA-A*11:01 bound to KRAS-G12V…

Browse structure collections

About this viewer

MolViewer shows 9W6A directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.