9WC1: ARP module in ncBAF complex

The structure of ARP module in ncBAF complex. Determined by electron microscopy at 3.4 Å resolution. Released 18 Feb 2026.

Method: Electron microscopy
Resolution: 3.4 Å
Organism: Homo sapiens
Chains: 4
Atoms: 7,032
Mol. weight: 293.76 kDa
Released: 18 Feb 2026

Explore 9WC1 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9WC1 contains 59 α-helices and 46 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 24 helices, 21 β-strands

Element	Residues	Length	Sheet
α-helix	6-7	2
β-strand	8-12	5	1
β-strand	17-21	5	1
β-strand	29-31	3	1
β-strand	35-38	4	2
β-strand	53-54	2	2
α-helix	56-60	5
β-strand	65-68	4	2
β-strand	71-72	2	3
β-strand	75-76	2	3
α-helix	79-88	10
α-helix	89-94	6
α-helix	98-100	3
β-strand	103-107	5	1
α-helix	113-121	9
α-helix	122-127	6
β-strand	131-136	6	1
α-helix	137-144	8
β-strand	150-154	5	4
β-strand	155	1	5
β-strand	160-162	3	5
β-strand	163-166	4	4
β-strand	169-170	2	4
β-strand	176-178	3	5
α-helix	182-196	15
α-helix	203-215	13
α-helix	223-232	10
β-strand	238-241	4	6
β-strand	247-250	4	6
α-helix	253-256	4
α-helix	258-261	4
α-helix	264-267	4
α-helix	274-283	10
α-helix	290-295	6
β-strand	297-300	4	4
α-helix	302-305	4
α-helix	309-320	12
β-strand	329-330	2	4
α-helix	335-337	3
α-helix	338-348	11
α-helix	352-354	3
α-helix	356	1
β-strand	357-358	2	1
α-helix	359-365	7
α-helix	369-373	5

Chain B: 34 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	12-16	5	7
β-strand	20-25	6	7
β-strand	33-36	4	7
β-strand	39-42	4	8
α-helix	50-53	4
α-helix	59-61	3
β-strand	65-67	3	8
α-helix	70-73	4
β-strand	81-83	3	8
β-strand	86-87	2	9
β-strand	90-91	2	9
α-helix	94-103	10
α-helix	104-109	6
α-helix	113-115	3
β-strand	118-122	5	7
α-helix	128-136	9
α-helix	137-142	6
β-strand	146-151	6	7
α-helix	152-159	8
β-strand	165-170	6	10
β-strand	175-181	7	10
β-strand	184-185	2	10
α-helix	187-189	3
β-strand	191-193	3	10
α-helix	197-211	15
α-helix	218-220	3
β-strand	221-224	4	11
α-helix	227-228	2
α-helix	232-233	2
β-strand	235-237	3	11
α-helix	238	1
α-helix	241-245	5
α-helix	246-264	19
β-strand	266	1	12
α-helix	274-277	4
α-helix	281-282	2
β-strand	283-286	4	13
β-strand	292-295	4	13
α-helix	298-301	4
α-helix	304-307	4
α-helix	309-311	3
α-helix	323-333	11
α-helix	339-343	5
β-strand	346-349	4	10
α-helix	351-354	4
β-strand	356	1	12
α-helix	358-369	12
α-helix	375-376	2
β-strand	378-379	2	10
α-helix	380	1
α-helix	385-388	4
α-helix	390-399	10
α-helix	402-407	6
β-strand	409-410	2	7
α-helix	411-417	7
α-helix	418-420	3
α-helix	421-425	5

Chain C: 0 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	31-37	7	14
β-strand	44-50	7	14

Chain D: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	2-62	61

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Actin, cytoplasmic 1	A	protein	375	Homo sapiens	P60709 (AlphaFold model)
Actin-like protein 6A	B	protein	429	Homo sapiens	O96019 (AlphaFold model)
B-cell CLL/lymphoma 7 protein family member A	C	protein	210	Homo sapiens	Q4VC05 (AlphaFold model)
Isoform 2 of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A…	D	protein	1614	Homo sapiens	P51532 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>9WC1_1 Actin, cytoplasmic 1 (chains A)
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF

Sequence of entity 2 (B), FASTA

>9WC1_2 Actin-like protein 6A (chains B)
MSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMVVERDDGSTLMEIDGDK
GKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPV
LMSEAPWNTRAKREKLTELMFEHYNIPAFFLCKTAVLTAFANGRSTGLILDSGATHTTAI
PVHDGYVLQQGIVKSPLAGDFITMQCRELFQEMNIELVPPYMIASKEAVREGSPANWKRK
EKLPQVTRSWHNYMCNCVIQDFQASVLQVSDSTYDEQVAAQMPTVHYEFPNGYNCDFGAE
RLKIPEGLFDPSNVKGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIVAGGNTLIQSF
TDRLNRELSQKTPPSMRLKLIANNTTVERRFSSWIGGSILASLGTFQQMWISKQEYEEGG
KQCVERKCP

Sequence of entity 3 (C), FASTA

>9WC1_3 B-cell CLL/lymphoma 7 protein family member A (chains C)
MSGRSVRAETRSRAKDDIKRVMAAIEKVRKWEKKWVTVGDTSLRIYKWVPVTEPKVDDKN
KNKKKGKDEKCGSEVTTPENSSSPGMMDMHDDNSNQSSIADASPIKQENSSNSSPAPEPN
SAVPSDGTEAKVDEAQADGKEHPGAEDASDEQNSQSSMEHSMNSSEKVDRQPSGDSGLAA
ETSAISQDLEGVPPSKKMKLEASQQNSEEM

Sequence of entity 4 (D), FASTA

>9WC1_4 Isoform 2 of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (chains D)
MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQG
PGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGY
PSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQL
RAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGP
GPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQ
KLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRG
LDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEV
VVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSIL
QHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRK
LIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIG
PDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEES
GSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGV
SQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADE
MGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAA
RRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTH
YVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEE
TILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTD
GSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASG
KFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLK
TFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVR
VLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEE
DEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAE
VERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKR
KRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYK
DSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLC
QNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSV
KVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGSGSEED

Primary citation

ncBAF recognizes the nucleosome through BCL7A in chromatin remodeling. Chen, K., Du, L., Liu, Y. et al. Cell Discov (2025) 11:102-102. DOI 10.1038/s41421-025-00858-1 · PubMed

Other PDB entries of the same protein (UniProt P60709 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6MBK 1.69 Å, SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, First…
6OX0 1.75 Å, SETD3 in Complex with an Actin Peptide with Sinefungin Replacing SAH as Cofactor
6MBJ 1.78 Å, SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, P21…
6OX3 1.78 Å, SETD3 in Complex with an Actin Peptide with His73 Replaced with Lysine
7W28 1.79 Å, Crystal Structure of SETD3-SAH in complex with betaA-4PyrAla73 peptide
6OX1 1.95 Å, SETD3 in Complex with an Actin Peptide with Target Histidine Partially Methylated
6ICT 1.95 Å, Structure of SETD3 bound to SAH and methylated actin
6OX2 2.09 Å, SETD3in Complex with an Actin Peptide with the Target Histidine Fully Methylated
6OX5 2.1 Å, A SETD3 Mutant (N255A) in Complex with an Actin Peptide with His73 Replaced with Lysine
6ICV 2.15 Å, Structure of SETD3 bound to SAH and unmodified actin
9QEW 2.18 Å, Cryo-EM structure of the undecorated actin filament in the ADP-Pi state.
6MBL 2.2 Å, SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, Second…

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