9WDI: MC5aR2

Structure of mC5aR2 in complex with mC5a-desArg. Determined by electron microscopy at 3.33 Å resolution. Released 1 Jul 2026.

Method: Electron microscopy
Resolution: 3.33 Å
Organism: Mus musculus
Chains: 4
Atoms: 5,504
Mol. weight: 105.8 kDa
Released: 1 Jul 2026

Explore 9WDI in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9WDI contains 32 α-helices and 6 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and C: 12 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	39-68	30
α-helix	74-76	3
α-helix	77-101	25
α-helix	110-143	34
α-helix	145-147	3
α-helix	151-177	27
β-strand	179-185	7	1
β-strand	188-194	7	1
α-helix	200-211	12
α-helix	212-216	5
α-helix	217-232	16
α-helix	238-263	26
α-helix	270-300	31
α-helix	302-313	12

Chains B and D: 4 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	4-14	11
α-helix	19-28	10
α-helix	37-41	5
α-helix	48-66	19
β-strand	71	1	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
C5a anaphylatoxin chemotactic receptor 2	A, C	protein	400	Mus musculus	E9QQ21 (AlphaFold model)
Complement C5	B, D	protein	76	Mus musculus	P06684 (AlphaFold model)

Sequence of entity 1 (A, C), FASTA

>9WDI_1 C5a anaphylatoxin chemotactic receptor 2 (chains A, C)
MGKTIIALSYIFCLVFADYKDDDDAANFTPVNGSSGNQSVRLVTSSSLEVLFQGPGSMNH
TTSEYYDYEYDHEHYSDLPDVPVDCPAGTCFTSDVYLIVLLVLYAAVFLVGVPGNTLVAW
VTWKESRHRLGASWFLHLTMADLLCCVSLPFLAVPIAQKGHWPYGAAGCWLLSSITILSM
YASVLLLTGLSGDLFLLAFRPSWKGADHRTFGVRVVQASSWMLGLLLTVPSAVYRRLLQE
HYPPRLVCGIDYGGSVSAEVAITTVRFLFGFLGPLVFMAGCHGILQRQMARRHWPLGTAV
VVGFFICWTPYHVLRVIIAAAPPHSLLLARVLEAEPLFNGLALAHSALNPIMFLYFGRKQ
LCKSLQAACHWALRDPQDEESAVTKVSISTSHEMVSEMPV

Sequence of entity 2 (B, D), FASTA

>9WDI_2 Complement C5 (chains B, D)
NLHLLRQKIEEQAAKYKHSVPKKCCYDGARVNFYETCEERVARVTIGPLCIRAFNECCTI
ANKIRKESPHKPVQLG

Primary citation

Molecular mechanisms of naturally encoded signaling bias at the complement anaphylatoxin receptors. Tiwari, D., Sawada, K., Dalal, A. et al. Mol Cell (2026) 86:2586. DOI 10.1016/j.molcel.2026.06.002 · PubMed

Other PDB entries of the same protein (UniProt E9QQ21 (AlphaFold model), which also has an AlphaFold model), best resolution first:

25IF 3.42 Å, Structure of mC5aR2 in complex with mC5a-desArg (Monomer)

Browse structure collections

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