9WF2: GGCX-BGP complex

Cryo-EM structure of GGCX-BGP complex. Determined by electron microscopy at 2.94 Å resolution. Released 22 Apr 2026.

Method
Electron microscopy
Resolution
2.94 Å
Organism
Homo sapiens
Chains
2
Atoms
5,985
Mol. weight
94.04 kDa
Ligands
A1AT1, CLR, MX7, POV
Released
22 Apr 2026

Explore 9WF2 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9WF2 contains 45 α-helices and 18 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 43 helices, 17 β-strands

ElementResiduesLengthSheet
α-helix33-386
α-helix42-454
α-helix48-558
β-strand58-5922
α-helix62-8120
α-helix85-873
α-helix88-914
α-helix109-1113
α-helix112-13120
α-helix135-15218
α-helix154-1563
α-helix159-17315
α-helix176-1783
α-helix182-1865
α-helix188-1903
β-strand195-19622
α-helix197-21721
α-helix221-2244
α-helix230-2345
α-helix236-2383
α-helix239-2424
α-helix247-2493
α-helix250-2589
α-helix259-27113
α-helix276-29318
α-helix299-3068
α-helix307-3104
α-helix315-3217
α-helix325-3306
α-helix332-3332
α-helix336-3394
α-helix358-37619
α-helix377-3826
α-helix385-3873
β-strand406-417121
β-strand423-42641
α-helix436-4394
α-helix441-45414
α-helix455-4584
β-strand463-473111
β-strand47813
β-strand479-48021
β-strand48214
β-strand50214
α-helix503-5053
α-helix507-5093
α-helix510-52213
β-strand527-53483
β-strand539-54355
β-strand552-55763
β-strand560-56455
β-strand569-57355
β-strand578-58033
β-strand586-59165
α-helix5961
β-strand597-60483
α-helix606-61712
α-helix657-67317
α-helix679-70830
α-helix713-72412
Chain B: 2 helices, 1 β-strand
ElementResiduesLengthSheet
β-strand36-3721
α-helix39-424
α-helix89-968

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
OsteocalcinBprotein68Homo sapiensP02818 (AlphaFold model)
Vitamin K-dependent gamma-carboxylaseAprotein697Homo sapiensP38435 (AlphaFold model)
Sequence of entity 1 (B), FASTA
>9WF2_1 Osteocalcin (chains B)
GAAFVSKQEGSEVVKRQRRYLYQWLGAPVPYPDPLERRREVCELNPDCDELADHIGFQEA
YRRFYGPV
Sequence of entity 2 (A), FASTA
>9WF2_2 Vitamin K-dependent gamma-carboxylase (chains A)
SRIGKLLGFEWTDLSSWRRLVTLLNRPTDPASLAVFRFLFGFLMVLDIPQERGLSSLDRK
YLDGLDVCRFPLLDALRPLPLDWMYLVYTIMFLGALGMMLGLCYRISCVLFLLPYWYVFL
LDKTSWNNHSYLYGLLAFQLTFMDANHYWSVDGLLNAHRRNAHVPLWNYAVLRGQIFIVY
FIAGVKKLDADWVEGYSMEYLSRHWLFSPFKLLLSEELTSLLVVHWGGLLLDLSAGFLLF
FDVSRSIGLFFVSYFHCMNSQLFSIGMFSYVMLASSPLFCSPEWPRKLVSYCPRRLQQLL
PLKAAPQPSVSCVYKRSRGKSGQKPGLRHQLGAAFTLLYLLEQLFLPYSHFLTQGYNNWT
NGLYGYSWDMMVHSRSHQHVKITYRDGRTGELGYLNPGVFTQSRRWKDHADMLKQYATCL
SRLLPKYNVTEPQIYFDIWVSINDRFQQRIFDPRVDIVQAAWSPFQRTSWVQPLLMDLSP
WRAKLQEIKSSLDNHTEVVFIADFPGLHLENFVSEDLGNTSIQLLQGEVTVELVAEQKNQ
TLREGEKMQLPAGEYHKVYTTSPSPSCYMYVYVNTTELALEQDLAYLQELKEKVENGSET
GPLPPELQPLLEGEVKGGPEPTPLVQTFLRRQQRLQEIERRRNTPFHERFFRFLLRKLYV
FRRSFLMTCISLRNLILGRPSLEQLAQEVTYANLRPF

Ligands and cofactors

IDNameFormulaCopies
A1AT1(1aR,7aS)-1a-methyl-7a-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tet…C31 H40 O31
CLRCholesterolC27 H46 O1
MX7(2R)-3-(phosphonooxy)propane-1,2-diyl (9Z,9'Z)bis-octadec-9-enoateC39 H73 O8 P1
POV(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl…C42 H82 N O8 P2
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O62

Primary citation

Cryo-EM structure of GGCX-BGP complex. Qian, H.W., Zhang, W.J. To be published.

Other PDB entries of the same protein (UniProt P02818 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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