Arginine ADP-riboxanase OspC3 (ospC3) is a 484-residue protein from Shigella flexneri. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: A0A0H2US87.
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The mean pLDDT of this model is 87.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 74% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
ADP-riboxanase effector that inhibits host cell pyroptosis (PubMed:23684308, PubMed:34409271, PubMed:34671164, PubMed:36624349). Acts by mediating arginine ADP-riboxanation of host CASP4/CASP11, blocking CASP4/CASP11 autoprocessing (PubMed:34671164, PubMed:35338844, PubMed:35568036, PubMed:36624349, PubMed:37014865). This prevents CASP4 activation and ability to recognize and cleave GSDMD, thereby inhibiting LPS-induced pyroptosis (PubMed:34671164, PubMed:36624349). ADP-riboxanation takes place in two steps: OspC3 first catalyzes ADP-ribosylation of target Arg, and then initiates a deamination to remove one N-omega group (PubMed:34671164). Independently of its ADP-riboxanase activity, acts…
Interacts with host calmodulin (CALM1, CALM2 and/or CALM3); specifically interacts with the apo form of calmodulin, preventing calcium-binding
Secreted, Host cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7WR2 | X-ray | 1.54 Å | A=332-484 |
| 7WR3 | X-ray | 1.87 Å | A/B=52-484 |
| 7WR1 | X-ray | 2.13 Å | C/D=332-484 |
| 7WR4 | X-ray | 2.75 Å | A=53-474 |
| 7WR5 | X-ray | 3.1 Å | A=53-474 |
| 8J6K | X-ray | 3.12 Å | C=332-484 |
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