T cell receptor beta variable 6-5 (TRBV6-5) is a 114-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: A0A0K0K1A5.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 91.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 82% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the…
Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked (PubMed:26875526). The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer,…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2BNU | X-ray | 1.4 Å | B=22-114 |
| 2BNQ | X-ray | 1.7 Å | E=22-114 |
| 2BNR | X-ray | 1.9 Å | E=22-114 |
| 8RLT | X-ray | 2.25 Å | E/J=20-112 |
| 8RLU | X-ray | 2.35 Å | E/J=20-112 |
| 1BD2 | X-ray | 2.5 Å | E=20-114 |
| 6Q3S | X-ray | 2.5 Å | E=22-114 |
| 5E9D | X-ray | 2.51 Å | E/J=20-112 |
| 1AO7 | X-ray | 2.6 Å | E=20-114 |
| 8RLV | X-ray | 2.61 Å | E/J=20-112 |
| 5MEN | X-ray | 2.81 Å | E=21-114 |
| 7FJE | EM | 3.0 Å | n=1-112 |
| 4WWK | X-ray | 3.1 Å | B=19-113 |
| 7FJF | EM | 3.1 Å | n=1-112 |
| 8TW6 | EM | 3.1 Å | B=2-114 |
| 7FJD | EM | 3.2 Å | n=1-112 |
| 8TW4 | EM | 3.3 Å | B=2-114 |
| 6JXR | EM | 3.7 Å | n=23-112 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.