Guanine nucleotide-binding protein G(s) subunit alpha (GNAS) is a 237-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Jun 2022. UniProt accession: A0A590UJY2.
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The mean pLDDT of this model is 85.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 50% |
| 70 to 90 | Confident: backbone generally right | 41% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs)
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 21DU | EM | 2.9 Å | A=47-237 |
| 8K4S | EM | 2.9 Å | A=47-237 |
| 9LWC | EM | 2.9 Å | A=47-237 |
| 9DQH | EM | 2.92 Å | B=47-237 |
| 9IZG | EM | 3.04 Å | A=47-237 |
| 9ASB | EM | 3.4 Å | A=50-94, A=109-229, A=232-237 |
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