Plexin-B2 (Plxnb2) is a 1842-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: B2RXS4.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 82.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 54% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (PubMed:17554007, PubMed:21122816). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (PubMed:29981480). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (PubMed:17554007). Also acts as a cell surface receptor for angiogenin (ANG); promoting ANG endocytosis and translocation to the cytoplasm or nucleus (PubMed:29100074). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development…
Monomer, and heterodimer with PLXNB1 (By similarity). Interacts with MET (By similarity). Interacts with ARHGEF11 (By similarity). Interacts with ARHGEF12 (By similarity). Interacts with RHOD (PubMed:34114565). May also interact with MST1R (By similarity)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.