PlexinB2 cytoplasmic region/PDZ-RhoGEF PDZ domain complex. Determined by X-ray diffraction at 3.21 Å resolution. Released 18 Nov 2015.
Explore 5E6P in 3D Show helices and sheets RCSB PDB PDBe
5E6P contains 31 α-helices and 26 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 1278 | 1 | 1 |
| α-helix | 1279-1280 | 2 | |
| α-helix | 1281-1290 | 10 | |
| β-strand | 1293 | 1 | 2 |
| β-strand | 1296 | 1 | 2 |
| α-helix | 1313-1327 | 15 | |
| α-helix | 1330-1342 | 13 | |
| α-helix | 1348-1361 | 14 | |
| α-helix | 1366-1385 | 20 | |
| α-helix | 1400-1412 | 13 | |
| α-helix | 1414-1416 | 3 | |
| α-helix | 1417-1421 | 5 | |
| α-helix | 1422-1437 | 16 | |
| β-strand | 1441 | 1 | 3 |
| β-strand | 1448 | 1 | 3 |
| β-strand | 1457 | 1 | 3 |
| β-strand | 1466-1474 | 9 | 4 |
| β-strand | 1479-1486 | 8 | 4 |
| β-strand | 1490 | 1 | 5 |
| α-helix | 1491-1502 | 12 | |
| α-helix | 1508-1510 | 3 | |
| α-helix | 1512-1513 | 2 | |
| β-strand | 1518-1521 | 4 | 4 |
| β-strand | 1529-1530 | 2 | 4 |
| β-strand | 1538-1539 | 2 | 6 |
| β-strand | 1544-1545 | 2 | 6 |
| α-helix | 1546-1547 | 2 | |
| β-strand | 1548 | 1 | 5 |
| β-strand | 1559-1563 | 5 | 4 |
| β-strand | 1592-1593 | 2 | 6 |
| α-helix | 1623-1647 | 25 | |
| α-helix | 1656-1671 | 16 | |
| α-helix | 1677-1687 | 11 | |
| α-helix | 1689-1693 | 5 | |
| α-helix | 1694-1698 | 5 | |
| α-helix | 1700-1702 | 3 | |
| β-strand | 1704 | 1 | 1 |
| α-helix | 1710-1725 | 16 | |
| α-helix | 1740-1744 | 5 | |
| α-helix | 1747-1764 | 18 | |
| α-helix | 1767-1768 | 2 | |
| α-helix | 1771-1785 | 15 | |
| α-helix | 1786-1788 | 3 | |
| α-helix | 1791-1804 | 14 | |
| α-helix | 1806-1815 | 10 | |
| α-helix | 1817-1821 | 5 | |
| α-helix | 1824-1834 | 11 | |
| β-strand | 1839-1841 | 3 | 7 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 46-50 | 5 | 7 |
| β-strand | 53-54 | 2 | 8 |
| β-strand | 56 | 1 | 8 |
| β-strand | 59-62 | 4 | 7 |
| β-strand | 68-72 | 5 | 7 |
| β-strand | 88-92 | 5 | 7 |
| β-strand | 95-96 | 2 | 7 |
| α-helix | 102-110 | 9 | |
| β-strand | 115-120 | 6 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Plexin-B2 | A | protein | 621 | Mus musculus | B2RXS4 (AlphaFold model) |
| Rho guanine nucleotide exchange factor 11 | B | protein | 88 | Homo sapiens | O15085 (AlphaFold model) |
>5E6P_1 Plexin-B2 (chains A) GPHMRKSQQAEREYEKIKSQLEGLEESVRDRCKKEFTDLMIEMEDQTNDVHEAGIPTLDY KTYTDRVFFLPSKDGDKDVMITGKLDIPESRRPIVEQALYQFSNLLNSKSFLINFIHTLE NQREFSARAKVYFASLLTVALHGKLEYYTDIMRTLFLELMEQYVVAKNPKLMLRRSETVV ERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDD VEYAPLTVSVIVQDEGIDAIPVKVLNCDTISQVKEKIIDQVYRTQPCSCWPKPDSVVLEW RPGSTAQILSDLDLTSQREGRWKRINTLMHYNVRDGATLILSKVGVSQQPEDSQQDLPGE RHALLEEENRVWHLVRPTDEVDEGKSKRGSMKEKERTKAITEIYLTRLLSVKGTLQQFVD NFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHDIRDEDTIHIWKTNSLPLRFWVNILKNPH FIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKKMVEDYYK GIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQK MQLAFRLQQIAAALENKVTDL
>5E6P_2 Rho guanine nucleotide exchange factor 11 (chains B) GPHMGLVQRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMV TNSSHLEVVKLIKSGAYVALTLLGSSPS
Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF. Pascoe, H.G., Gutowski, S., Chen, H. et al. Proc Natl Acad Sci U S A (2015) 112:14852-14857. DOI 10.1073/pnas.1508931112 · PubMed
Other PDB entries of the same protein (UniProt B2RXS4 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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