Methylated-DNA--protein-cysteine methyltransferase is a 182-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Jun 2022. UniProt accession: E5BBQ0.
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The mean pLDDT of this model is 90.5 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 79% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3KZY | X-ray | 1.9 Å | A/B=1-182 |
| 6Y8P | X-ray | 2.3 Å | A=7-182 |
| 8TK7 | EM | 2.53 Å | D/E/F=1-182 |
| 8DD7 | EM | 3.3 Å | A=1-181, B=5-181 |
| 6RLA | EM | 3.9 Å | A/B=5-181 |
| 6SC2 | EM | 3.9 Å | A/B=5-181 |
| 6RLB | EM | 4.5 Å | A/B=5-181 |
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