Uracil-DNA glycosylase (ORF46) is a 255-residue protein from Human herpesvirus 8 type P. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: F5HFA1.
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The mean pLDDT of this model is 91.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 86% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes
Host nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5NNH | X-ray | 2.2 Å | A=19-255 |
| 5NN7 | X-ray | 2.5 Å | A=21-255 |
| 6LYV | X-ray | 2.7 Å | A/C/E/G/I/K/M/O=1-255 |
| 5NNU | X-ray | 2.97 Å | A/B/D/E=19-255 |
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