P2X purinoceptor 4a (p2rx4a) is a 389-residue protein from Danio rerio. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: F8W463.
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The mean pLDDT of this model is 89.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 73% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (By similarity). CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4 (PubMed:28332633). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (By similarity). Could also function as an ATP-gated cation channel of lysosomal membranes (By similarity)
Functional P2XRs are organized as homomeric and heteromeric trimers (By similarity). Forms homotrimer (PubMed:22535247, PubMed:28332633)
Cell membrane, Lysosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4DW1 | X-ray | 2.8 Å | A=28-365 |
| 5WZY | X-ray | 2.8 Å | A=28-365 |
| 4DW0 | X-ray | 2.9 Å | A=28-365 |
| 3H9V | X-ray | 3.1 Å | A=28-381 |
| 8JV5 | EM | 3.23 Å | A/B/C=9-359 |
| 8JV6 | EM | 3.43 Å | A/B/C=9-358 |
| 3I5D | X-ray | 3.46 Å | A/B/C=28-381 |
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