Metabotropic glutamate receptor 8 (GRM8) is a 908-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O00222.
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The mean pLDDT of this model is 84.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 51% |
| 70 to 90 | Confident: backbone generally right | 35% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity
Interacts with PICK1
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6BSZ | X-ray | 2.65 Å | A/B=37-514 |
| 6BT5 | X-ray | 2.92 Å | A/B=37-514 |
| 6E5V | X-ray | 2.95 Å | A/B=2-508 |
| 9MB9 | EM | 2.97 Å | D/R=1-908 |
| 9MBC | EM | 2.97 Å | A/B=1-908 |
| 9MBA | EM | 3.14 Å | D/R=1-908 |
| 9MBB | EM | 3.25 Å | A/B=1-908 |
| 9MBD | EM | 3.32 Å | A/B=1-908 |
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