Cell division cycle 7-related protein kinase (CDC7) is a 574-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O00311.
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The mean pLDDT of this model is 71.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 37% |
What pLDDT means and how to read it
Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN
Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity (PubMed:10373557, PubMed:12065429, PubMed:15668232, PubMed:17062569). Interacts with CLASPIN (via the acidic patch); the interaction is required for phosphorylation of MCM proteins and CLASPIN (PubMed:27401717)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6YA6 | X-ray | 1.44 Å | A=37-467, A=534-574 |
| 6YA7 | X-ray | 1.67 Å | A=37-466, A=534-574 |
| 6YA8 | X-ray | 1.79 Å | A=37-467, A=534-574 |
| 4F9C | X-ray | 2.08 Å | A=37-574 |
| 4F9A | X-ray | 2.17 Å | A/C=37-574 |
| 5UWR | X-ray | 2.24 Å | D=456-478 |
| 5UWQ | X-ray | 2.28 Å | D=456-473 |
| 4F99 | X-ray | 2.33 Å | A=37-574 |
| 4F9B | X-ray | 2.5 Å | A/C=37-574 |
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