Cdc7-Dbf4 bound to an Mcm2-S40 derived bivalent substrate. Determined by X-ray diffraction at 1.67 Å resolution. Released 27 May 2020.
Explore 6YA7 in 3D Show helices and sheets RCSB PDB PDBe
6YA7 contains 28 α-helices and 21 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 40-50 | 11 | |
| α-helix | 52-56 | 5 | |
| β-strand | 58-66 | 9 | 1 |
| β-strand | 70-77 | 8 | 1 |
| β-strand | 79 | 1 | 2 |
| β-strand | 85-92 | 8 | 1 |
| α-helix | 98-110 | 13 | |
| β-strand | 114 | 1 | 3 |
| β-strand | 117 | 1 | 3 |
| β-strand | 122-126 | 5 | 1 |
| β-strand | 129-135 | 7 | 1 |
| α-helix | 142-145 | 4 | |
| α-helix | 151-170 | 20 | |
| β-strand | 173-174 | 2 | 4 |
| α-helix | 180-182 | 3 | |
| β-strand | 183-186 | 4 | 3 |
| β-strand | 191-194 | 4 | 3 |
| β-strand | 201-202 | 2 | 4 |
| α-helix | 209-213 | 5 | |
| β-strand | 215 | 1 | 4 |
| β-strand | 358-359 | 2 | 5 |
| α-helix | 361-364 | 4 | |
| α-helix | 367-369 | 3 | |
| α-helix | 382-385 | 4 | |
| α-helix | 394-409 | 16 | |
| α-helix | 420-431 | 12 | |
| α-helix | 433-442 | 10 | |
| β-strand | 445-449 | 5 | 6 |
| α-helix | 454-457 | 4 | |
| α-helix | 458-466 | 9 | |
| α-helix | 471-537 | 5 | |
| α-helix | 540-549 | 10 | |
| α-helix | 558-559 | 2 | |
| α-helix | 560-563 | 4 | |
| α-helix | 567-569 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 213-214 | 2 | 5 |
| α-helix | 215-216 | 2 | |
| β-strand | 219-224 | 6 | 6 |
| β-strand | 232-235 | 4 | 6 |
| α-helix | 247 | 1 | |
| β-strand | 294-296 | 3 | 7 |
| β-strand | 301-303 | 3 | 7 |
| α-helix | 306-310 | 5 | |
| α-helix | 313-319 | 7 | |
| α-helix | 322-324 | 3 | |
| α-helix | 325-331 | 7 | |
| β-strand | 338 | 1 | 2 |
| α-helix | 341-346 | 6 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 39-41 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase,Cell… | A | protein | 358 | Homo sapiens | O00311 (AlphaFold model) |
| Protein DBF4 homolog A | B | protein | 144 | Homo sapiens | Q9UBU7 (AlphaFold model) |
| DNA replication licensing factor MCM2 | C | protein | 15 | Homo sapiens | P49736 (AlphaFold model) |
>6YA7_1 Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase (chains A) LAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTS HPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVRE YMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQS EAQQERCSQNKPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTA IDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVP AQDLRKLCERLRGAGAGGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
>6YA7_2 Protein DBF4 homolog A (chains B) GPGTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMPFINYSIQKPCSPFDVDKPSSMQKQTQ VKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLLSEQHRNFAQSNQYQV VDDIVSKLVFDFVEYEKDTPKKKR
>6YA7_3 DNA replication licensing factor MCM2 (chains C) RRTDALTASPGRDLP
Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase. Dick, S.D., Federico, S., Hughes, S.M. et al. Structure (2020) 28:954-962.e4. DOI 10.1016/j.str.2020.05.010 · PubMed
Other PDB entries of the same protein (UniProt O00311 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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