Nuclear receptor subfamily 5 group A member 2 (NR5A2) is a 541-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O00482.
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The mean pLDDT of this model is 72.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 33% |
What pLDDT means and how to read it
Orphan nuclear receptor that binds DNA as a monomer to the 5'-TCAAGGCCA-3' sequence and controls expression of target genes: regulates key biological processes, such as early embryonic development, cholesterol and bile acid synthesis pathways, as well as liver and pancreas morphogenesis (PubMed:16289203, PubMed:18410128, PubMed:21614002, PubMed:32433991, PubMed:38409506, PubMed:9786908). Ligand-binding causes conformational change which causes recruitment of coactivators, promoting target gene activation (PubMed:21614002). The specific ligand is unknown, but specific phospholipids, such as phosphatidylethanolamine, phosphatidylserine, dilauroyl phosphatidylcholine and diundecanoyl…
Monomer; Binds DNA as a monomer (PubMed:16289203, PubMed:38409506). Interacts with nuclear receptor corepressors NR0B1 and NR0B2; repressing NR5A2 nuclear receptor activity (PubMed:15723037, PubMed:22504882, PubMed:26416531, PubMed:32433991). Interacts with nuclear receptor coactivators CTNNB1, PPARGC1A and NCOA2; interaction takes place following ligand-binding and promotes target gene…
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6VC2 | X-ray | 1.7 Å | A=299-541 |
| 3PLZ | X-ray | 1.75 Å | A/B=300-541 |
| 4PLD | X-ray | 1.75 Å | A=301-541 |
| 4PLE | X-ray | 1.75 Å | A/C/E/G=301-541 |
| 4ONI | X-ray | 1.8 Å | A/B=291-541 |
| 5L11 | X-ray | 1.85 Å | A=299-541 |
| 4RWV | X-ray | 1.86 Å | A=294-541 |
| 1YUC | X-ray | 1.9 Å | A/B=290-541 |
| 4DOR | X-ray | 1.9 Å | A/B=290-541 |
| 5SYZ | X-ray | 1.93 Å | A=297-538 |
| 5UNJ | X-ray | 1.96 Å | A=299-541 |
| 4DOS | X-ray | 2.0 Å | A=299-538 |
| 6OQX | X-ray | 2.0 Å | A=299-541 |
| 6OR1 | X-ray | 2.17 Å | A=299-541 |
| 2A66 | X-ray | 2.2 Å | A=79-187 |
| 5L0M | X-ray | 2.2 Å | A=79-187 |
| 9SMQ | X-ray | 2.2 Å | A=297-541 |
| 6OQY | X-ray | 2.23 Å | A=299-541 |
| 6VIF | X-ray | 2.26 Å | A=299-541 |
| 7JYD | X-ray | 2.3 Å | A=299-541 |
Showing 20 of 28 experimental structures (best resolution first).
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