C3a anaphylatoxin chemotactic receptor (C3ar1) is a 477-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O09047.
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The mean pLDDT of this model is 70.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 31% |
What pLDDT means and how to read it
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a, stimulating chemotaxis, granule enzyme release and superoxide anion production (PubMed:9164946, PubMed:9382922). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). C3AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase (By similarity)
Interacts with VGF-derived peptide TLQP-21 (PubMed:25456411). Interacts (when phosphorylated) with ARRB1; the interaction is associated with internalization of the receptor and short-term desensitization to the ligand (By similarity)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9KV6 | EM | 2.88 Å | E=2-477 |
| 9KV8 | EM | 3.17 Å | C=2-477 |
| 9KZ8 | EM | 3.3 Å | C=2-477 |
| 9UMJ | EM | 3.38 Å | C=2-477 |
| 9KZK | EM | 3.54 Å | E=2-477 |
| 9L0H | EM | 3.57 Å | E=2-477 |
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