Segment polarity protein dishevelled homolog DVL-2 (DVL2) is a 736-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O14641.
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The mean pLDDT of this model is 58.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 17% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 57% |
What pLDDT means and how to read it
Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling
Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Rac. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Can form large oligomers (via DIX domain). Interacts (via DIX domain) with DIXDC1 (via DIX domain). Interacts (via DEP domain) with AP2M1 and the AP-2 complex (By similarity). Interacts with DACT1 and…
Cell membrane, Cytoplasm, cytosol, Cytoplasmic vesicle, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3CBZ | X-ray | 1.38 Å | A=264-354 |
| 3CBY | X-ray | 1.5 Å | A/B=264-354 |
| 2REY | X-ray | 1.55 Å | A=261-355 |
| 6IW3 | X-ray | 1.64 Å | A=12-93 |
| 3CBX | X-ray | 1.7 Å | A/B=264-354 |
| 3CC0 | X-ray | 1.75 Å | A/B/C=264-354 |
| 8WWR | X-ray | 1.75 Å | A=261-354 |
| 5SUZ | X-ray | 1.84 Å | A/B=416-509 |
| 5SUY | X-ray | 1.88 Å | A/B/C/D=416-510 |
| 5LNP | X-ray | 1.99 Å | A/B/C/D=416-510 |
| 4WIP | X-ray | 2.69 Å | A/B/C=12-106 |
| 8YR7 | X-ray | 3.0 Å | A=261-353 |
| 6JCK | X-ray | 3.09 Å | B=12-93 |
| 8WMA | EM | 3.47 Å | C=1-736 |
| 8WM9 | EM | 3.53 Å | C=1-736 |
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