Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a 440-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O14763.
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The mean pLDDT of this model is 71.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 39% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 33% |
What pLDDT means and how to read it
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis
Monomer (PubMed:10549288). Can interact with TRADD and RIPK1. Interacts with HCMV protein UL141; this interaction prevents TNFRSF10B cell surface expression. Two TNFRSF10B monomers interact with a UL141 homodimer. Three TNFRSF10B molecules interact with TNFSF10 homotrimer (PubMed:10549288). In the absence of stimulation, interacts with BIRC2, DDX3X and GSK3B. The interaction with BIRC2 and DDX3X…
Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3X3F | X-ray | 2.1 Å | A=54-184 |
| 4I9X | X-ray | 2.1 Å | C/D=58-184 |
| 1D4V | X-ray | 2.2 Å | A=69-184 |
| 1DU3 | X-ray | 2.2 Å | A/B/C/G/H/I=54-183 |
| 2H9G | X-ray | 2.32 Å | R/S=54-183 |
| 1D0G | X-ray | 2.4 Å | R/S/T=54-183 |
| 6T3J | X-ray | 3.05 Å | E/J=58-184 |
| 4OD2 | X-ray | 3.2 Å | S=73-183 |
| 4N90 | X-ray | 3.3 Å | R/S/T=57-182 |
| 1ZA3 | X-ray | 3.35 Å | R/S=54-183 |
| 6NHW | NMR | A/B/C/D/E/F=208-242 | |
| 6NHY | NMR | A/B/C=208-242 | |
| 8DPX | NMR | A/B/C=77-184 |
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