Growth/differentiation factor 8 (MSTN) is a 375-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O14793.
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The mean pLDDT of this model is 78.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 36% |
| 70 to 90 | Confident: backbone generally right | 40% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Acts specifically as a negative regulator of skeletal muscle growth
Homodimer; disulfide-linked (PubMed:27625211). Interacts with WFIKKN2, leading to inhibit its activity (PubMed:12595574). Interacts with FST3 (PubMed:17878677)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5F3B | X-ray | 1.76 Å | C/D=267-375 |
| 5NTU | X-ray | 2.58 Å | A/B=43-375 |
| 5F3H | X-ray | 2.7 Å | I/J/K/L=268-375 |
| 6UMX | X-ray | 2.79 Å | A/B=24-375 |
| 5NXS | X-ray | 4.19 Å | A/B=43-375 |
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