Ras-related protein M-Ras (MRAS) is a 208-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O14807.
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The mean pLDDT of this model is 86.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 72% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:16630891, PubMed:28289718, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The formation of the SMP complex only occurs when MRAS is GTP-bound (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39809765). Unlike other Ras proteins, MRAS has low intrinsic GTPase activity and may require additional factors for activation (PubMed:39809765). The SMP…
Component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex consisting of SHOC2, GTP-bound M-Ras/MRAS and the catalytic subunit of protein phosphatase 1 (either PPP1CA, PPP1CB or PPP1CC) (PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39809765). Interacts (active GTP-bound form) with both SHOC2 and PP1c (all isoforms) to form a tertiary complex;…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9O0P | X-ray | 1.5 Å | A/B=1-178 |
| 9O0Q | X-ray | 1.9 Å | A/B/C=1-178 |
| 7TXH | X-ray | 1.95 Å | A/D=1-178 |
| 9C1A | X-ray | 1.96 Å | A=1-178 |
| 9B4R | X-ray | 2.1 Å | A=11-178 |
| 7TVF | X-ray | 2.17 Å | B/E=1-178 |
| 9C1B | X-ray | 2.27 Å | A/B/C/D=1-204 |
| 9B4T | X-ray | 2.75 Å | B=1-178 |
| 9MEZ | X-ray | 2.8 Å | A/C/E/G/I=1-181 |
| 7UPI | EM | 2.89 Å | A=1-182 |
| 7SD0 | EM | 2.95 Å | B=1-208 |
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