Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6) is a 153-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O14933.
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The mean pLDDT of this model is 95.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 95% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins (PubMed:15131269, PubMed:16428300). Functions in the E6/E6-AP-induced ubiquitination of p53/TP53 (PubMed:16427630). Promotes ubiquitination and subsequent proteasomal degradation of FLT3 (PubMed:20508617)
Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated)
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1WZV | X-ray | 2.1 Å | A/B=2-153 |
| 1WZW | X-ray | 2.4 Å | A=2-153 |
| 8SE9 | EM | 3.2 Å | C=2-153 |
| 8SEB | EM | 3.24 Å | C=2-153 |
| 8SV8 | EM | 3.38 Å | C=2-153 |
| 8SEA | EM | 3.4 Å | C=2-153 |
| 8OIF | EM | 3.5 Å | L=1-153 |
| 2KJH | NMR | A=2-153 |
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