DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) is a 346-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O15160.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 92.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 78% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. POLR1C/RPAC1 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft
Component of the RNA polymerase I and RNA polymerase III complexes consisting of at least 13 and 17 subunits, respectively (PubMed:12391170, PubMed:26151409, PubMed:33335104). Pol I complex consists of a ten-subunit catalytic core composed of POLR1A/RPA1, POLR1B/RPA2, POLR1C/RPAC1, POLR1D/RPAC2, POLR1H/RPA12, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile…
Nucleus, Nucleus, nucleolus, Cytoplasm, cytosol
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7OB9 | EM | 2.7 Å | C=1-346 |
| 7AE1 | EM | 2.8 Å | C=1-346 |
| 9K39 | EM | 2.8 Å | C=1-346 |
| 7VBB | EM | 2.81 Å | C=1-346 |
| 7VBA | EM | 2.89 Å | C=1-346 |
| 7D58 | EM | 2.9 Å | C=1-346 |
| 9K36 | EM | 2.9 Å | C=1-346 |
| 9K2G | EM | 3.0 Å | C=1-346 |
| 9K3U | EM | 3.0 Å | C=1-346 |
| 7VBC | EM | 3.01 Å | C=1-346 |
| 7AE3 | EM | 3.1 Å | C=1-346 |
| 7D59 | EM | 3.1 Å | C=1-346 |
| 7OBA | EM | 3.1 Å | C=1-346 |
| 9K38 | EM | 3.1 Å | C=1-346 |
| 9FSO | EM | 3.28 Å | K=1-346 |
| 7A6H | EM | 3.3 Å | C=1-346 |
| 7OBB | EM | 3.3 Å | C=1-346 |
| 9LXN | EM | 3.3 Å | C=1-346 |
| 7DU2 | EM | 3.35 Å | C=1-346 |
| 9FSP | EM | 3.39 Å | K=1-346 |
Showing 20 of 36 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.