7OBA: Human RNA Polymerase I

Cryo-EM structure of human RNA Polymerase I in complex with RRN3. Determined by electron microscopy at 3.1 Å resolution. Released 8 Dec 2021.

Method: Electron microscopy
Resolution: 3.1 Å
Organism: Homo sapiens
Chains: 14
Atoms: 35,679
Mol. weight: 677.43 kDa
Ligands: ZN
Released: 8 Dec 2021

Explore 7OBA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7OBA contains 186 α-helices and 243 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 72 helices, 64 β-strands

Element	Residues	Length	Sheet
β-strand	14-19	6	1
α-helix	20-21	2
β-strand	31-32	2	2
β-strand	39	1	3
β-strand	45	1	3
α-helix	46	1
β-strand	79-80	2	2
β-strand	81-88	8	4
α-helix	93-98	6
β-strand	103	1	5
β-strand	110	1	5
α-helix	114-123	10
α-helix	137-148	12
α-helix	159-170	12
α-helix	182-198	17
β-strand	215-218	4	6
β-strand	222-225	4	6
β-strand	255	1	6
α-helix	258-272	15
α-helix	285-287	3
β-strand	298-302	5	4
α-helix	303-306	4
α-helix	307-309	3
α-helix	325-345	21
α-helix	388-402	15
α-helix	417-421	5
β-strand	436-437	2	7
β-strand	440-447	8	8
β-strand	455-458	4	8
β-strand	467-471	5	9
α-helix	482-485	4
β-strand	498	1	9
β-strand	504	1	9
α-helix	513-520	8
β-strand	537-541	5	9
α-helix	542	1
α-helix	546	1
β-strand	547-551	5	8
α-helix	558-560	3
β-strand	561-568	8	8
β-strand	575-577	3	8
α-helix	581-583	3
β-strand	593-597	5	8
α-helix	606-610	5
β-strand	613	1	8
β-strand	619	1	10
β-strand	626	1	10
α-helix	634-641	8
β-strand	647-648	2	11
α-helix	650-660	11
β-strand	675-677	3	12
β-strand	681	1	12
β-strand	682-683	2	11
α-helix	684-693	10
α-helix	701-704	4
β-strand	705-706	2	13
β-strand	738-740	3	13
β-strand	743-746	4	13
α-helix	751-754	4
α-helix	761-764	4
α-helix	774-786	13
β-strand	804	1	14
α-helix	818-820	3
α-helix	825-828	4
α-helix	839-849	11
α-helix	862-868	7
α-helix	873-880	8
β-strand	885	1	14
α-helix	893-899	7
α-helix	908-913	6
β-strand	918	1	15
β-strand	921	1	16
β-strand	924	1	16
α-helix	926-928	3
α-helix	939	1
α-helix	945-948	4
β-strand	950	1	15
α-helix	961-979	19
α-helix	986-995	10
β-strand	1001	1	17
β-strand	1007-1008	2	17
β-strand	1014-1016	3	17
α-helix	1019-1021	3
β-strand	1024	1	18
α-helix	1027-1029	3
α-helix	1034-1036	3
α-helix	1038-1041	4
α-helix	1044-1047	4
α-helix	1062-1064	3
α-helix	1068-1075	8
α-helix	1088-1096	9
α-helix	1117-1125	9
α-helix	1134-1137	4
α-helix	1142-1145	4
α-helix	1161-1177	17
α-helix	1189-1202	14
β-strand	1204	1	18
α-helix	1205-1206	2
α-helix	1211-1214	4
α-helix	1245-1252	8
β-strand	1264-1267	4	19
β-strand	1268	1	20
α-helix	1273-1283	11
β-strand	1289	1	21
α-helix	1290-1293	4
β-strand	1294-1301	8	22
β-strand	1304-1305	2	23
β-strand	1311-1312	2	23
β-strand	1313-1314	2	24
β-strand	1317-1321	5	22
α-helix	1322-1323	2
α-helix	1324-1326	3
α-helix	1337-1341	5
α-helix	1342-1346	5
α-helix	1347-1357	11
β-strand	1371	1	25
α-helix	1502-1506	5
β-strand	1512	1	26
β-strand	1526-1527	2	22
β-strand	1529	1	26
β-strand	1530-1531	2	24
α-helix	1543-1547	5
β-strand	1551	1	21
β-strand	1566	1	19
β-strand	1577-1580	4	19
α-helix	1585-1588	4
β-strand	1595	1	20
α-helix	1597-1599	3
β-strand	1601-1602	2	19
α-helix	1621-1629	9
α-helix	1638-1648	11
α-helix	1668-1674	7
α-helix	1679-1686	8
β-strand	1690	1	1
α-helix	1698-1700	3
β-strand	1713-1718	6	27

Chain B: 44 helices, 71 β-strands

Element	Residues	Length	Sheet
α-helix	27-28	2
α-helix	40-47	8
α-helix	48-52	5
α-helix	53-55	3
α-helix	62-63	2
β-strand	64-67	4	28
β-strand	72-75	4	28
β-strand	77-82	6	29
α-helix	83-85	3
β-strand	86	1	30
α-helix	87-88	2
β-strand	97	1	30
α-helix	100-105	6
β-strand	111-118	8	29
β-strand	121-122	2	28
β-strand	125-126	2	28
β-strand	130-138	9	29
α-helix	153-157	5
α-helix	161-162	2
β-strand	170-172	3	31
β-strand	175-179	5	31
β-strand	181-185	5	32
α-helix	186	1
β-strand	187	1	25
β-strand	191-194	4	25
α-helix	196-200	5
β-strand	205-216	12	25
β-strand	220-229	10	25
β-strand	234-239	6	25
β-strand	244-245	2	25
β-strand	248	1	25
α-helix	249-256	8
α-helix	261-267	7
α-helix	277-291	15
α-helix	297-307	11
α-helix	327-330	4
α-helix	339-357	19
α-helix	369-371	3
β-strand	372-375	4	32
α-helix	379-404	26
α-helix	428-436	9
β-strand	454-456	3	31
α-helix	462-466	5
β-strand	471-473	3	32
α-helix	485-487	3
α-helix	491-493	3
β-strand	497	1	33
β-strand	511-513	3	32
β-strand	514	1	33
β-strand	519-520	2	34
α-helix	529-536	8
β-strand	539-541	3	35
α-helix	549	1
β-strand	553-558	6	35
β-strand	561-567	7	35
α-helix	572-575	4
β-strand	594-598	5	35
α-helix	607-608	2
β-strand	609-613	5	35
β-strand	619-625	7	34
β-strand	630-635	6	34
α-helix	638-640	3
β-strand	658-660	3	34
α-helix	669-672	4
α-helix	682-688	7
β-strand	695	1	36
β-strand	710-714	5	37
β-strand	718	1	38
β-strand	722-723	2	39
α-helix	726-729	4
β-strand	739-745	7	40
β-strand	756-760	5	40
α-helix	761-766	6
β-strand	771-780	10	37
β-strand	792-794	3	41
α-helix	801-803	3
β-strand	807	1	42
β-strand	813	1	42
α-helix	814	1
β-strand	818-819	2	37
β-strand	824-826	3	43
β-strand	828-830	3	41
β-strand	836	1	41
β-strand	839-840	2	43
β-strand	847-854	8	37
β-strand	863	1	44
β-strand	866-873	8	37
β-strand	882-884	3	40
β-strand	891-897	7	40
α-helix	899-901	3
β-strand	905	1	45
β-strand	913-915	3	40
α-helix	927-939	13
β-strand	945-946	2	39
α-helix	962-968	7
β-strand	976-977	2	40
β-strand	979	1	45
β-strand	992-1001	10	40
β-strand	1002	1	36
β-strand	1013	1	8
α-helix	1016-1017	2
β-strand	1018	1	46
β-strand	1025	1	46
β-strand	1035-1036	2	7
α-helix	1039-1048	10
α-helix	1051-1055	5
α-helix	1056-1061	6
β-strand	1064-1070	7	47
β-strand	1079	1	48
α-helix	1081-1085	5
β-strand	1098	1	48
β-strand	1103	1	48
β-strand	1107-1113	7	47
α-helix	1116-1123	8
β-strand	1128-1133	6	1

Chain C: 15 helices, 18 β-strands

Element	Residues	Length	Sheet
α-helix	42-45	4
β-strand	50	1	49
β-strand	53-57	5	49
β-strand	60-66	7	49
α-helix	70-82	13
β-strand	86-95	10	50
α-helix	105-111	7
α-helix	114	1
β-strand	115	1	51
α-helix	119-121	3
α-helix	123-126	4
β-strand	138	1	50
β-strand	140-144	5	50
β-strand	147-148	2	52
α-helix	159-162	4
β-strand	163-164	2	52
β-strand	169	1	53
α-helix	170-172	3
β-strand	173-175	3	50
α-helix	181-184	4
β-strand	192	1	51
β-strand	198	1	53
β-strand	208-217	10	50
α-helix	223-225	3
β-strand	228-240	13	49
α-helix	247-249	3
α-helix	250-256	7
β-strand	262-267	6	54
β-strand	270-275	6	54
α-helix	278-280	3
α-helix	286-289	4
β-strand	298-312	15	49
α-helix	318-343	26

Chain E: 9 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	5-21	17
α-helix	22-24	3
α-helix	30-32	3
α-helix	39-42	4
β-strand	60-63	4	55
β-strand	71-75	5	55
β-strand	82	1	56
α-helix	90-95	6
β-strand	101-106	6	55
β-strand	110	1	56
α-helix	114-119	6
β-strand	126-131	6	55
α-helix	133-135	3
α-helix	139-141	3
β-strand	147-149	3	57
α-helix	153-162	10
β-strand	172-173	2	57
β-strand	190-195	6	57
β-strand	203-209	7	57

Chain F: 3 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	56	1	58
α-helix	59-71	13
α-helix	77-79	3
α-helix	89-98	10
β-strand	105-109	5	27
β-strand	115-119	5	27
β-strand	124	1	58

Chain G: 2 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	35-40	6
β-strand	43	1	59
β-strand	46	1	59
β-strand	49	1	60
β-strand	52-54	3	61
β-strand	57-59	3	62
α-helix	68-76	9
β-strand	90	1	60
β-strand	97-98	2	61
β-strand	102-105	4	27
β-strand	112-114	3	62
β-strand	116-119	4	61
β-strand	122	1	60
β-strand	135-138	4	63
β-strand	143-147	5	63
β-strand	151-155	5	63
β-strand	183-185	3	63
β-strand	193-195	3	63

Chain H: 0 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	4-15	12	12
β-strand	25-32	8	12
β-strand	38-44	7	12
β-strand	55-61	7	12
β-strand	65	1	64
β-strand	84	1	64
β-strand	90-98	9	12
β-strand	101	1	65
β-strand	112	1	65
β-strand	115-117	3	12
β-strand	118-119	2	66
β-strand	121	1	66
β-strand	123-124	2	12
β-strand	127	1	65
β-strand	140-147	8	12

Chain I: 3 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	14	1	67
β-strand	19	1	68
α-helix	25	1
β-strand	26	1	68
α-helix	27	1
β-strand	35-37	3	69
β-strand	44-46	3	69
α-helix	48-52	5
β-strand	55-60	6	22
β-strand	82-83	2	70
β-strand	95-99	5	70
β-strand	111-115	5	70
β-strand	121-124	4	70

6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase I subunit RPA1	A	protein	1720	Homo sapiens	O95602 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA2	B	protein	1135	Homo sapiens	Q9H9Y6 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	346	Homo sapiens	O15160 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	210	Homo sapiens	P19388 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Homo sapiens	P61218
DNA-directed RNA polymerase I subunit RPA43	G	protein	338	Homo sapiens	Q3B726
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Homo sapiens	P52434
DNA-directed RNA polymerase I subunit RPA12	I	protein	126	Homo sapiens	Q9P1U0
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Homo sapiens	P62875
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	133	Homo sapiens	P0DPB6
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	58	Homo sapiens	P53803
DNA-directed RNA polymerase I subunit RPA49	M	protein	419	Homo sapiens	Q9GZS1

2 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>7OBA_1 DNA-directed RNA polymerase I subunit RPA1 (chains A)
MLISKNMPWRRLQGISFGMYSAEELKKLSVKSITNPRYLDSLGNPSANGLYDLALGPADS
KEVCSTCVQDFSNCSGHLGHIELPLTVYNPLLFDKLYLLLRGSCLNCHMLTCPRAVIHLL
LCQLRVLEVGALQAVYELERILNRFLEENPDPSASEIREELEQYTTEIVQNNLLGSQGAH
VKNVCESKSKLIALFWKAHMNAKRCPHCKTGRSVVRKEHNSKLTITFPAMVHRTAGQKDS
EPLGIEEAQIGKRGYLTPTSAREHLSALWKNEGFFLNYLFSGMDDDGMESRFNPSVFFLD
FLVVPPSRYRPVSRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMAQEQKLPEEVATPTT
DEEKDSLIAIDRSFLSTLPGQSLIDKLYNIWIRLQSHVNIVFDSEMDKLMMDKYPGIRQI
LEKKEGLFRKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQEL
RQAVINGPNVHPGASMVINEDGSRTALSAVDMTQREAVAKQLLTPATGAPKPQGTKIVCR
HVKNGDILLLNRQPTLHRPSIQAHRARILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQ
SELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGASMTTRGCFFTREHYMELVYRG
LTDKVGRVKLLSPSILKPFPLWTGKQVVSTLLINIIPEDHIPLNLSGKAKITGKAWVKET
PRSVPGFNPDSMCESQVIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGKVLTC
LARLFTAYLQLYRGFTLGVEDILVKPKADVKRQRIIEESTHCGPQAVRAALNLPEAASYD
EVRGKWQDAHLGKDQRDFNMIDLKFKEEVNHYSNEINKACMPFGLHRQFPENSLQMMVQS
GAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIK
PPEFFFHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVVQYDLTVRDSDGSVVQFLYG
EDGLDIPKTQFLQPKQFPFLASNYEVIMKSQHLHEVLSRADPKKALHHFRAIKKWQSKHP
NTLLRRGAFLSYSQKIQEAVKALKLESENRNGRSPGTQEMLRMWYELDEESRRKYQKKAA
ACPDPSLSVWRPDIYFASVSETFETKVDDYSQEWAAQTEKSYEKSELSLDRLRTLLQLKW
QRSLCEPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASANIK
TPMMSVPVLNTKKALKRVKSLKKQLTRVCLGEVLQKIDVQESFCMEEKQNKFQVYQLRFQ
FLPHAYYQQEKCLRPEDILRFMETRFFKLLMESIKKKNNKASAFRNVNTRRATQRDLDNA
GELGRSRGEQEGDEEEEGHIVDAEAEEGDADASDAKRKEKQEEEVDYESEEEEEREGEEN
DDEDMQEERNPHREGARKTQEQDEEVGLGTEEDPSLPALLTQPRKPTHSQEPQGPEAMER
RVQAVREIHPFIDDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKGIT
RCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRV
IEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGIRSNSSPLQQMTFETSFQF
LKQATMLGSHDELRSPSACLVVGKVVRGGTGLFELKQPLR

Sequence of entity 2 (B), FASTA

>7OBA_2 DNA-directed RNA polymerase I subunit RPA2 (chains B)
MDPGSRWRNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGLGLAVQA
IPPFEFAFKDERISFTILDAVISPPTVPKGTICKEANVYPAECRGRRSTYRGKLTADINW
AVNGISKGIIKQFLGYVPIMVKSKLCNLRNLPPQALIEHHEEAEEMGGYFIINGIEKVIR
MLIMPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVNMNLHYLENGTVMLNFIY
RKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSFLRNSVSQMLRIVMEEGCSTQKQV
LNYLGECFRVKLNVPDWYPNEQAAEFLFNQCICIHLKSNTEKFYMLCLMTRKLFALAKGE
CMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGWLVSIKIAFDKKAQKTSVSMNTDNLMRIF
TMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLCVVADKLNFIRYLSHFRCVHRGADFAK
MRTTTVRRLLPESWGFLCPVHTPDGEPCGLMNHLTAVCEVVTQFVYTASIPALLCNLGVT
PIDGAPHRSYSECYPVLLDGVMVGWVDKDLAPGIADSLRHFKVLREKRIPPWMEVVLIPM
TGKPSLYPGLFLFTTPCRLVRPVQNLALGKEELIGTMEQIFMNVAIFEDEVFAGVTTHQE
LFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYRLQTPQSP
LVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFID
LSEKIKQGDSSLVFGIKPGDPRVLQKLDDDGLPFIGAKLQYGDPYYSYLNLNTGESFVMY
YKSKENCVVDNIKVCSNDTGSGKFKCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAE
DMPFTESGMVPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALE
YFGEMLKAAGYNFYGTERLYSGISGLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDR
VTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAHVCVKCGSLLSPL
LEKPPPSWSAMRNRKYNCTLCSRSDTIDTVSVPYVFRYFVAELAAMNIKVKLDVV

Sequence of entity 3 (C), FASTA

>7OBA_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS
LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR
LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN
QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT
LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA
RVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD

Sequence of entity 4 (E), FASTA

>7OBA_4 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 5 (F), FASTA

>7OBA_5 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIITD

Sequence of entity 6 (G), FASTA

>7OBA_6 DNA-directed RNA polymerase I subunit RPA43 (chains G)
MAAGCSEAPRPAAASDGSLVGQAGVLPCLELPTYAAACALVNSRYSCLVAGPHQRHIALS
PRYLNRKRTGIREQLDAELLRYSESLLGVPIAYDNIKVVGELGDIYDDQGHIHLNIEADF
VIFCPEPGQKLMGIVNKVSSSHIGCLVHGCFNASIPKPEQLSAEQWQTMEINMGDELEFE
VFRLDSDAAGVFCIRGKLNITSLQFKRSEVSEEVTENGTEEAAKKPKKKKKKKDPETYEV
DSGTTKLADDADDTPMEESALQNTNNANGIWEEEPKKKKKKKKHQEVQDQDPVFQGSDSS
GYQSDHKKKKKKRKHSEEAEFTPPLKCSPKRKGKSNFL

Sequence of entity 7 (H), FASTA

>7OBA_7 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 8 (I), FASTA

>7OBA_8 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVMDLANTCSSFQSDLDFCSDCGSVLPLPGAQDTVTCIRCGFNINVRDFEGKVVKTSVV
FHQLGTAMPMSVEEGPECQGPVVDRRCPRCGHEGMAYHTRQMRSADEGQTVFYTCTNCKF
QEKEDS

Sequence of entity 9 (J), FASTA

>7OBA_9 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 10 (K), FASTA

>7OBA_10 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MEEDQELERKISGLKTSMAEGERKTALEMVQAAGTDRHCVTFVLHEEDHTLGNSLRYMIM
KNPEVEFCGYTTTHPSESKINLRIQTRGTLPAVEPFQRGLNELMNVCQHVLDKFEASIKD
YKDQKASRNESTF

Sequence of entity 11 (L), FASTA

>7OBA_11 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Sequence of entity 12 (M), FASTA

>7OBA_12 DNA-directed RNA polymerase I subunit RPA49 (chains M)
MAAEVLPSARWQYCGAPDGSQRAVLVQFSNGKLQSPGNMRFTLYENKDSTNPRKRNQRIL
AAETDRLSYVGNNFGTGALKCNTLCRHFVGILNKTSGQMEVYDAELFNMQPLFSDVSVES
ELALESQTKTYREKMDSCIEAFGTTKQKRALNTRRMNRVGNESLNRAVAKAAETIIDTKG
VTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTS
EEILKMIEENSHCTFVIEALKSLPSDVESRDRQARCIWFLDTLIKFRAHRVVKRKSALGP
GVPHIINTKLLKHFTCLTYNNGRLRNLISDSMKAKITAYVIILALHIHDFQIDLTVLQRD
LKLSEKRMMEIAKAMRLKISKRRVSVAAGSEEDHKLGTLSLPLPPAQTSDRLAKRRKIT

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	7

Primary citation

Cryo-EM structures of human RNA polymerase I. Misiaszek, A.D., Girbig, M., Grotsch, H. et al. Nat Struct Mol Biol (2021) 28:997-1008. DOI 10.1038/s41594-021-00693-4 · PubMed

Other PDB entries of the same protein (UniProt O95602 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7OB9 2.7 Å, Cryo-EM structure of human RNA Polymerase I in elongation state
7VBB 2.81 Å, Structure of the post state human RNA Polymerase I Elongation Complex
7VBA 2.89 Å, Structure of the pre state human RNA Polymerase I Elongation Complex
7VBC 3.01 Å, Back track state of human RNA Polymerase I Elongation Complex
7OBB 3.3 Å, Cryo-EM structure of human RNA Polymerase I Open Complex
8A43 4.09 Å, Human RNA polymerase I

Browse structure collections

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