Neurosecretory protein VGF (VGF) is a 615-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O15240.
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The mean pLDDT of this model is 60.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 11% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 33% |
| Below 50 | Very low: often disordered regions | 38% |
What pLDDT means and how to read it
Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity)
Interacts with HSPA8 on cell membrane (PubMed:28934328). Interacts with C3AR1 (By similarity). Interacts with C1QBP (By similarity)
Secreted, Cytoplasmic vesicle, secretory vesicle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9KV8 | EM | 3.17 Å | D=554-574 |
| 7D13 | NMR | A=310-347 | |
| 7D16 | NMR | A=310-347 | |
| 8H0G | NMR | A=586-615 | |
| 8H0U | NMR | A=586-615 |
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