ATP-dependent helicase fft3 (fft3) is a 922-residue protein from Schizosaccharomyces pombe (strain 972 / ATCC 24843). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O42861.
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The mean pLDDT of this model is 66.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 22% |
| 70 to 90 | Confident: backbone generally right | 35% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 32% |
What pLDDT means and how to read it
Protein that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization (PubMed:15317843, PubMed:18422602, PubMed:21437270, PubMed:26902262, PubMed:28218250, PubMed:31575705). Required for maintaining heterochromatin at centromeres and subtelomeres by protecting these regions from euchromatin assembly (PubMed:15317843, PubMed:21437270). Plays a role in transcription elongation by RNA polymerase II (RNAPII); together with the FACT complex, mediates nucleosome disassembly at transcribing regions to promote the efficient passage of RNAPII through chromatin (PubMed:28218250). Involved in DNA repair-dependent chromatin…
Interacts with the GDP-bound form of spi1 (PubMed:18422602). Interacts with RNA polymerase II (RNAPII); to promote the efficient passage of RNAPII through chromatin (PubMed:28218250). Interacts with the FACT complex subunit spt16; to mediate nucleosome disassembly at transcribing regions and promote the efficient passage of RNAPII through chromatin (PubMed:28218250)
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7XWY | X-ray | 2.25 Å | A=232-620 |
| 7XXE | X-ray | 4.2 Å | A/B=626-903 |
| 7XYF | EM | 4.3 Å | K=232-903 |
| 7XYG | EM | 5.4 Å | K=1-922 |
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