PHD finger protein 1 (PHF1) is a 567-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O43189.
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The mean pLDDT of this model is 71.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 50% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 37% |
What pLDDT means and how to read it
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464, PubMed:23273982). According to another report, PHF1…
Interacts with CHMP1 (By similarity). Associated component of the PRC2 complex. Interacts with p53/TP53
Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6WAV | X-ray | 1.7 Å | A/B/C/D=28-87 |
| 6WAT | X-ray | 1.8 Å | AA/AC/BA/BC/CA/CC/DA/DC/EA/EC/FA/FC/GA/GC/HA/HC/IA/IC/JA/JC/KA/KC/LA/LC/MA/MC/NA/NC/OA/OC=28-87 |
| 4HCZ | X-ray | 1.85 Å | A/B=28-85 |
| 7LKY | X-ray | 1.85 Å | A/B/C/D/E/F/G/H=28-87 |
| 5XFN | X-ray | 1.9 Å | A=25-340 |
| 5XFO | X-ray | 1.9 Å | A=25-340 |
| 5XFP | X-ray | 2.3 Å | A/B/E=25-360 |
| 8H43 | X-ray | 2.3 Å | A/B/C=28-87 |
| 2E5P | NMR | A=29-83 | |
| 2M0O | NMR | A=6-83 |
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