Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) is a 606-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O43318.
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The mean pLDDT of this model is 69.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 36% |
What pLDDT means and how to read it
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor…
Can form homodimer (PubMed:27426733). Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with TAB1/MAP3K7IP1, TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3 (PubMed:10838074, PubMed:11460167, PubMed:12242293, PubMed:14670075, PubMed:16289117, PubMed:19675569, PubMed:8638164). Identified in the TRIKA2 complex composed of MAP3K7/TAK1, TAB1/MAP3K7IP1 and…
Cytoplasm, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7NTH | X-ray | 1.97 Å | A=31-303 |
| 7NTI | X-ray | 1.98 Å | A=31-303 |
| 2EVA | X-ray | 2.0 Å | A=31-305 |
| 5JGA | X-ray | 2.0 Å | A=31-303 |
| 5V5N | X-ray | 2.01 Å | A=31-303 |
| 8GW3 | X-ray | 2.05 Å | A/B/C/D=15-303 |
| 5E7R | X-ray | 2.11 Å | A=31-303 |
| 4GS6 | X-ray | 2.2 Å | A=31-303 |
| 5J7S | X-ray | 2.37 Å | A=31-303 |
| 5JH6 | X-ray | 2.37 Å | A=31-303 |
| 5JK3 | X-ray | 2.37 Å | A=31-303 |
| 4O91 | X-ray | 2.39 Å | A=31-303 |
| 5J8I | X-ray | 2.4 Å | A=31-303 |
| 9FPD | X-ray | 2.4 Å | A=31-303 |
| 2YIY | X-ray | 2.49 Å | A=31-303 |
| 4L52 | X-ray | 2.54 Å | A=31-303 |
| 4L53 | X-ray | 2.55 Å | A=31-303 |
| 5GJG | X-ray | 2.61 Å | A=31-303 |
| 4L3P | X-ray | 2.68 Å | A=31-303 |
| 5J9L | X-ray | 2.75 Å | A=31-303 |
Showing 20 of 25 experimental structures (best resolution first).
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