Neuronal migration protein doublecortin (DCX) is a 365-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O43602.
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The mean pLDDT of this model is 66.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 10% |
| 70 to 90 | Confident: backbone generally right | 36% |
| 50 to 70 | Low: treat with caution | 25% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration
Interacts with tubulin (PubMed:27292316). Interacts with USP9X (PubMed:24607389)
Cytoplasm, Cell projection, neuron projection
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5IO9 | X-ray | 1.3 Å | A/B=52-149 |
| 5IP4 | X-ray | 1.81 Å | D/E=170-260 |
| 5IKC | X-ray | 2.06 Å | M/N=52-140 |
| 2BQQ | X-ray | 2.2 Å | A=45-150 |
| 6FNZ | X-ray | 2.23 Å | A/B/C/D=174-254 |
| 5IOI | X-ray | 2.4 Å | A/B/C/D/E/F=52-150 |
| 5IN7 | X-ray | 2.48 Å | A/B=46-150 |
| 6REV | EM | 3.8 Å | N=44-142 |
| 6RF8 | EM | 3.8 Å | N=44-142 |
| 6RFD | EM | 3.9 Å | N=44-142 |
| 6RF2 | EM | 4.2 Å | C=178-264 |
| 2XRP | EM | 8.2 Å | I=46-140 |
| 4ATU | EM | 8.3 Å | I=2-365 |
| 1MJD | NMR | A=45-150 |
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