Orexin/Hypocretin receptor type 1 (HCRTR1) is a 425-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O43613.
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The mean pLDDT of this model is 78.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 19% |
What pLDDT means and how to read it
G protein-coupled receptor that binds the neuropeptide orexin-A with high affinity, and orexin-B with lower affinity, two peptides derived from a common precursor, prepro-orexin (PubMed:32669442, PubMed:9491897). Its activity is mediated via a G(q)-protein-coupled pathway, which activates the phosphatidylinositol-calcium second messenger system in response to orexin-A binding (PubMed:32669442). In addition to G(q)-mediated signaling, orexin-A stimulation also promotes beta-arrestin recruitment, leading to receptor internalization (PubMed:15683363, PubMed:32669442). Plays a significant role in the regulation of food intake (By similarity)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6TOD | X-ray | 2.11 Å | A/B=28-380 |
| 6TOS | X-ray | 2.13 Å | A/B=28-380 |
| 6TOT | X-ray | 2.22 Å | A/B=28-380 |
| 6TO7 | X-ray | 2.26 Å | A/B=28-380 |
| 6TQ4 | X-ray | 2.3 Å | A/B=28-380 |
| 6TP6 | X-ray | 2.34 Å | A/B=28-380 |
| 6TQ6 | X-ray | 2.55 Å | A/B=28-380 |
| 6TQ9 | X-ray | 2.65 Å | A/B=28-381 |
| 6TQ7 | X-ray | 2.66 Å | A/B=28-380 |
| 4ZJ8 | X-ray | 2.75 Å | A=1-246, A=288-380 |
| 4ZJC | X-ray | 2.83 Å | A=1-246, A=288-380 |
| 6TP4 | X-ray | 3.01 Å | A/B=28-380 |
| 6TP3 | X-ray | 3.04 Å | A/B=28-380 |
| 6V9S | X-ray | 3.5 Å | A=1-246, A=288-380 |
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