Kalirin (KALRN) is a 1257-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O60229.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 67.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 33% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 35% |
What pLDDT means and how to read it
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity
Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) (By similarity). Interacts with FASLG
Cytoplasm, Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8C7D | X-ray | 1.86 Å | A=1916-2114 |
| 5QQJ | X-ray | 1.9 Å | B=1280-1459 |
| 5QQD | X-ray | 1.91 Å | B=1280-1459 |
| 5QQE | X-ray | 1.95 Å | B=1280-1459 |
| 5QU9 | X-ray | 2.0 Å | B=1280-1459 |
| 5QQM | X-ray | 2.02 Å | B=1280-1459 |
| 5QQI | X-ray | 2.08 Å | B=1280-1459 |
| 5QQH | X-ray | 2.09 Å | B=1280-1459 |
| 5QQG | X-ray | 2.23 Å | B=1280-1459 |
| 5QQK | X-ray | 2.24 Å | B=1280-1459 |
| 5QQL | X-ray | 2.25 Å | B=1280-1459 |
| 5QQF | X-ray | 2.26 Å | B=1280-1459 |
| 5QQN | X-ray | 2.26 Å | B=1280-1459 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.