Sodium channel regulatory subunit beta-2 (SCN2B) is a 215-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O60939.
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The mean pLDDT of this model is 85.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 65% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes (PubMed:19808477, PubMed:23559163, PubMed:26894959, PubMed:30765605, PubMed:30765606, PubMed:35277491, PubMed:36823201). Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals…
A voltage-gated sodium (Nav) channel consists of an ion-conducting pore-forming alpha subunit functional on its own that is regulated by one or more beta subunits (PubMed:22992729). The beta subunit SCN2B is disulfide-linked to the pore-forming alpha subunit (PubMed:22992729). Interacts with SCN1A; regulatory subunit of SCN1A/Nav1.1 (PubMed:22992729). Interacts with SCN2A; regulatory subunit of…
Cell membrane, Cell projection, axon
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5FEB | X-ray | 1.35 Å | A=30-151 |
| 6VRR | X-ray | 1.45 Å | A=30-153 |
| 5FDY | X-ray | 1.85 Å | A/B=30-153 |
| 7W9K | EM | 2.2 Å | C=1-215 |
| 8I5Y | EM | 2.6 Å | C=1-215 |
| 21TQ | EM | 2.7 Å | C=30-148 |
| 7XVE | EM | 2.7 Å | C=1-215 |
| 8I5B | EM | 2.7 Å | C=1-215 |
| 8I5G | EM | 2.7 Å | C=1-215 |
| 8THH | EM | 2.7 Å | C=1-215 |
| 7XVF | EM | 2.8 Å | C=1-215 |
| 8G1A | EM | 2.8 Å | C=1-215 |
| 7W9P | EM | 2.9 Å | C=1-215 |
| 8I5X | EM | 2.9 Å | C=1-215 |
| 8S9B | EM | 2.9 Å | C=1-215 |
| 8THG | EM | 2.9 Å | C=1-215 |
| 21TP | EM | 3.0 Å | C=30-148 |
| 6J8E | EM | 3.0 Å | C=27-148 |
| 7W9M | EM | 3.0 Å | C=1-215 |
| 7W9T | EM | 3.0 Å | C=1-215 |
Showing 20 of 35 experimental structures (best resolution first).
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