Meiotically up-regulated gene 135 protein (mug135) is a 357-residue protein from Schizosaccharomyces pombe (strain 972 / ATCC 24843). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O74876.
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The mean pLDDT of this model is 85.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Promotes unequal transmission of alleles from the parental zygote to daughter cells by acting as a poison/antidote system (PubMed:39485795, PubMed:39485800). Protein present in spores adopts a toxic structural conformation, whereas protein produced in germinating cells adopts the antidote conformation, thereby leading to killing of non-carrier progeny in heterozygous crosses (PubMed:16303567, PubMed:39485795, PubMed:39485800). The toxic structural conformation is recruited to nuclear foci in a bdf1-dependent manner; these toxic foci disrupt mitotic chromosome segregation unless neutralized by antidote (PubMed:39485795, PubMed:39485800)
Tetramer (PubMed:39485800). Protein expressed in vegetative cells is autoinhibited for bdf1 binding due to its adoption of a tetrameric structure (PubMed:39485800). Interacts (via C-terminus) with bdf1 (via C-terminus); the interaction is direct and required for tdk1-mediated killer meiotic drive (PubMed:39485795, PubMed:39485800)
Nucleus, Chromosome, Spore core
Compare the prediction with experimentally determined structures of the same protein:
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