GATOR1 complex protein DEPDC5 (DEPDC5) is a 1603-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O75140.
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The mean pLDDT of this model is 64.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 18% |
| 70 to 90 | Confident: backbone generally right | 38% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 36% |
What pLDDT means and how to read it
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:31548394, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:35338845). In the presence of abundant amino acids, the GATOR1…
Within the GATOR complex, component of the GATOR1 subcomplex, made of DEPDC5, NPRL2 and NPRL3 (PubMed:23723238, PubMed:25366275, PubMed:29590090, PubMed:35338845). GATOR1 mediates the strong interaction of the GATOR complex with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) heterodimers (PubMed:23723238, PubMed:29590090). Interacts with SAMTOR; interaction is direct…
Lysosome membrane, Cytoplasm, cytosol, Cytoplasm, perinuclear region
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9V0J | EM | 2.97 Å | C=1-1603 |
| 8FW5 | EM | 3.08 Å | A=1-1603 |
| 9O5A | EM | 3.2 Å | B=1-1603 |
| 9O5D | EM | 3.34 Å | B=1-1603 |
| 9XZY | EM | 3.8 Å | H=1-1603 |
| 7T3B | EM | 3.9 Å | A=1-1603 |
| 6CES | EM | 4.0 Å | D=1-1603 |
| 7T3A | EM | 4.0 Å | A=1-1603 |
| 7T3C | EM | 4.0 Å | A=1-1603 |
| 6CET | EM | 4.4 Å | D=1-1603 |
| 9O5E | EM | 5.0 Å | H/J=1-1603 |
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