Rab11 family-interacting protein 3 (RAB11FIP3) is a 756-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O75154.
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The mean pLDDT of this model is 65.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 44% |
What pLDDT means and how to read it
Downstream effector molecule for Rab11 GTPase which is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery (PubMed:15601896, PubMed:16148947, PubMed:17394487, PubMed:17628206, PubMed:18511905, PubMed:19327867, PubMed:20026645, PubMed:25673879, PubMed:26258637, PubMed:31204173). Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex (PubMed:20026645). The functional Rab11-RAB11FIP3-dynein complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of…
Homodimer (PubMed:17007872, PubMed:17030804). Interacts with RAB11A; the interaction is direct and is required for the recruitment to endosomes (PubMed:11495908, PubMed:15601896, PubMed:17030804, PubMed:17229837, PubMed:31204173). Interacts with RAB11B (PubMed:11495908). Forms a ternary complex with RAB11A and dynein intermediate chain DYNC1LI1; RAB11FIP3 links RAB11A to dynein and the…
Endosome membrane, Recycling endosome membrane, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cleavage furrow, Midbody, Golgi apparatus membrane, Golgi apparatus, trans-Golgi network membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2D7C | X-ray | 1.75 Å | C/D=715-756 |
| 2HV8 | X-ray | 1.86 Å | D/E/F=695-756 |
| 4UJ3 | X-ray | 3.0 Å | C/F/I/L/O/R/U/X=695-756 |
| 4UJ4 | X-ray | 4.2 Å | C/F/I/L=695-756 |
| 4D0M | X-ray | 6.0 Å | E/F/K/L/U/V/a/b/e/f/i/j=713-756 |
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